Category: Diagnostics

Dynamic Assessment of Hematological Parameters as Predictive Biomarkers for Disease Severity and Prognosis in COVID-19 Patients: A Longitudinal Study

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Aparna P. Patange • Jabbar V. Desai • Bhupal Pujari • Aparna Marwah • Animesh Dey, Published: July 01, 2024, DOI: 10.7759/cureus.63593  Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to substantial morbidity and mortality worldwide. Hematological abnormalities are common in COVID-19 patients and play a significant role in disease pathogenesis and prognosis. Objective: […]

The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches

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Roxana Gheorghita1,2Iuliana Soldanescu3Andrei Lobiuc2 , et. al., Front. Immunol., 03 March 2024, Sec. Viral Immunology, Volume 15 – 2024 | https://doi.org/10.3389/fimmu.2024.1344086 The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has been defined as the greatest global health and socioeconomic crisis of modern times. While most people recover after being infected with the virus, a significant […]

Long Covid Defined

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Authors: E. Wesley Ely, M.D., M.P.H. https://orcid.org/0000-0003-3957-2172, Lisa M. Brown, M.P.H., and Harvey V. Fineberg, M.D., Ph.D., for the National Academies of Sciences, Engineering, and Medicine Committee on Examining the Working Definition for Long Covid, DOI: 10.1056/NEJMsb2408466 The Covid-19 pandemic has been perceived mainly as a dangerous acute outbreak of infection that killed more than a million people in the United States and 7 million worldwide.1,2 However, […]

Retrospective Evaluation of Hematological Parameters in COVID-19 Patients: Insights From the Emergency Department

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Ahmed Jerah, May 28, 2024, DOI: 10.7759/cureus.61258 Cite this article as: Jerah A (May 28, 2024) Retrospective Evaluation of Hematological Parameters in COVID-19 Patients: Insights From the Emergency Department. Cureus 16(5): e61258. doi:10.7759/cureus.61258 Abstract Background: This retrospective study evaluated hematological parameters in coronavirus disease 2019 (COVID-19) patients to gain clinical insights. Methods: Data from the Emergency Department of Samtah […]

Long COVID: major findings, mechanisms and recommendations

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Hannah E. Davis, , Lisa McCorkell, Julia Moore Vogel, Eric J. Topol Nature Reviews Microbiology volume 21, pages133–146 (2023)Cite this article Abstract Long COVID is an often debilitating illness that occurs in at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. More than 200 symptoms have been identified with impacts on multiple organ systems. At least 65 million individuals […]

Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization

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Maxime Taquet, Zuzanna Skorniewska, Adam Hampshire, James D. Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Olivia C. Leavy, Matthew Richardson, Omer Elneima, Hamish J. C. McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Ruth M. Saunders, Victoria C. Harris, Linzy Houchen-Wolloff, Neil J. Greening, Parisa Mansoori, Ewen M. Harrison, Annemarie B. Docherty, Nazir I. Lone, PHOSP-COVID Study Collaborative Group,  Nature Medicine (August 2023)  Abstract Post-COVID cognitive deficits, including ‘brain fog’, are clinically complex, with both objective and […]

Neurological manifestations of post-acute sequelae of COVID-19: which liquid biomarker should we use?

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Dominique Comeau1† Mykella Martin2† Gilles A. Robichaud3,4,5 Ludivine Chamard-Witkowski2,6*1Dr. Georges-L. Long COVID syndrome, also known as post-acute sequelae of COVID-19 (PASC), is characterized by persistent symptoms lasting 3–12 weeks post SARS-CoV-2 infection. Patients suffering from PASC can display a myriad of symptoms that greatly diminish quality of life, the most frequent being neuropsychiatric. Thus, there is an eminent need […]

COVID-19 and emerging spinal cord complications: A systematic review

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Ritwick Mondal,a Shramana Deb,b Gourav Shome,c Upasana Ganguly,a Durjoy Lahiri,a,d,⁎ and Julián Benito-Leóne,f,g,⁎⁎ Mult Scler Relat Disord. 2021 Jun; 51: 102917.Published online 2021 Mar 21. doi: 10.1016/j.msard.2021.102917 PMCID: PMC7981271 PMID: 33845350 Abstract Background : Spinal cord complications associated with coronavirus infectious disease of 2019 (COVID-19) are being widely reported. The purpose of this systematic review was to summarize so far available pieces of evidence documenting de novo novel severe […]

An overview of human proteins and genes involved in SARS-CoV-2 infection

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Zohreh Jahanafrooz,a,⁎ Zhishan Chen,b Jiandong Bao,c Hongzhi Li,d Loren Lipworth,b and Xingyi Guob,e,⁎Gene. 2022 Jan 15; 808: 145963. Published online 2021 Sep 14. doi: 10.1016/j.gene.2021.145963 PMCID: PMC8437745PMID: 34530086 Graphical abstract A summarized view of recent findings of host proteins interacting with SARS-CoV-2 and genes containing associated variants with COVID-19 susceptibility and severity. The left side of the figure (A) shows host protein interactors (blue wrote) for […]

Saliva changes in composition associated to COVID-19: a preliminary study

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Alberto Muñoz-Prieto, Ivana Rubić, Juan Carlos Gonzalez-Sanchez, Josipa Kuleš, Silvia Martínez-Subiela, José Joaquín Cerón, Enrique Bernal, Alberto Torres-Cantero, María Rosario Vicente-Romero, Vladimir Mrljak & Asta Tvarijonaviciute  Scientific Reports volume 12, Article number: 10879 (2022) Cite this article Abstract The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2), is usually associated with a wide variety of clinical presentations from asymptomatic to severe cases. The use of […]