Long COVID: major findings, mechanisms and recommendations


Hannah E. Davis, , Lisa McCorkell, Julia Moore Vogel, Eric J. Topol Nature Reviews Microbiology volume 21, pages133–146 (2023)Cite this article Abstract Long COVID is an often debilitating illness that occurs in at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. More than 200 symptoms have been identified with impacts on multiple organ systems. At least 65 million individuals […]

Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization


Maxime Taquet, Zuzanna Skorniewska, Adam Hampshire, James D. Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Olivia C. Leavy, Matthew Richardson, Omer Elneima, Hamish J. C. McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Ruth M. Saunders, Victoria C. Harris, Linzy Houchen-Wolloff, Neil J. Greening, Parisa Mansoori, Ewen M. Harrison, Annemarie B. Docherty, Nazir I. Lone, PHOSP-COVID Study Collaborative Group,  Nature Medicine (August 2023)  Abstract Post-COVID cognitive deficits, including ‘brain fog’, are clinically complex, with both objective and […]

Neurological manifestations of post-acute sequelae of COVID-19: which liquid biomarker should we use?


Dominique Comeau1† Mykella Martin2† Gilles A. Robichaud3,4,5 Ludivine Chamard-Witkowski2,6*1Dr. Georges-L. Long COVID syndrome, also known as post-acute sequelae of COVID-19 (PASC), is characterized by persistent symptoms lasting 3–12 weeks post SARS-CoV-2 infection. Patients suffering from PASC can display a myriad of symptoms that greatly diminish quality of life, the most frequent being neuropsychiatric. Thus, there is an eminent need […]

COVID-19 and emerging spinal cord complications: A systematic review


Ritwick Mondal,a Shramana Deb,b Gourav Shome,c Upasana Ganguly,a Durjoy Lahiri,a,d,⁎ and Julián Benito-Leóne,f,g,⁎⁎ Mult Scler Relat Disord. 2021 Jun; 51: 102917.Published online 2021 Mar 21. doi: 10.1016/j.msard.2021.102917 PMCID: PMC7981271 PMID: 33845350 Abstract Background : Spinal cord complications associated with coronavirus infectious disease of 2019 (COVID-19) are being widely reported. The purpose of this systematic review was to summarize so far available pieces of evidence documenting de novo novel severe […]

An overview of human proteins and genes involved in SARS-CoV-2 infection


Zohreh Jahanafrooz,a,⁎ Zhishan Chen,b Jiandong Bao,c Hongzhi Li,d Loren Lipworth,b and Xingyi Guob,e,⁎Gene. 2022 Jan 15; 808: 145963. Published online 2021 Sep 14. doi: 10.1016/j.gene.2021.145963 PMCID: PMC8437745PMID: 34530086 Graphical abstract A summarized view of recent findings of host proteins interacting with SARS-CoV-2 and genes containing associated variants with COVID-19 susceptibility and severity. The left side of the figure (A) shows host protein interactors (blue wrote) for […]

Saliva changes in composition associated to COVID-19: a preliminary study


Alberto Muñoz-Prieto, Ivana Rubić, Juan Carlos Gonzalez-Sanchez, Josipa Kuleš, Silvia Martínez-Subiela, José Joaquín Cerón, Enrique Bernal, Alberto Torres-Cantero, María Rosario Vicente-Romero, Vladimir Mrljak & Asta Tvarijonaviciute  Scientific Reports volume 12, Article number: 10879 (2022) Cite this article Abstract The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2), is usually associated with a wide variety of clinical presentations from asymptomatic to severe cases. The use of […]

A blood test for long Covid is possible, a study suggests


Scientists can now show key differences in the blood of those who recover from Covid — and those who don’t. Sept. 25, 2023, 11:01 AM EDT By Erika Edwards NBC Health More than three years into the pandemic, the millions of people who have suffered from long Covid finally have scientific proof that their condition is […]

Detection of SARS-CoV-2 viral proteins and genomic sequences in human brainstem nuclei


Aron Emmi, Stefania Rizzo, Luisa Barzon, Michele Sandre, Elisa Carturan, Alessandro Sinigaglia, Silvia Riccetti, Mila Della Barbera, Rafael Boscolo-Berto, Patrizia Cocco, Veronica Macchi, Angelo Antonini, Monica De Gaspari, Cristina Basso, Raffaele De Caro & Andrea Porzionato  npj Parkinson’s Disease volume 9, Article number: 25 (2023) Cite this articleAbstract Open Access Published: 13 February 2023 Neurological manifestations are common in COVID-19, the disease caused by SARS-CoV-2. Despite reports of SARS-CoV-2 detection in the brain and cerebrospinal fluid of COVID-19 […]

CSF and blood biomarkers in COVID-19 and other neuroinfectious diseases


Matteo Foschi1,2 Samir Abu-Rumeileh3 Federico Massa4 Christian Cordano4,5 Ahmed Abdelhak5* 11 July 2023 Frontiers in Medicine CSF and blood biomarkers in COVID-19 and other neuroinfectious diseases The past decades have witnessed advances in the development of ultrasensitive assays to measure biofluid markers to improve the diagnosis and characterization of central nervous system (CNS) involvement in primary and non-primary neurological […]

Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization


Maxime Taquet, Zuzanna Skorniewska, Adam Hampshire, James D. Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Olivia C. Leavy, Matthew Richardson, Omer Elneima, Hamish J. C. McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Ruth M. Saunders, Victoria C. Harris, Linzy Houchen-Wolloff, Neil J. Greening, Parisa Mansoori, Ewen M. Harrison, Annemarie B. Docherty, Nazir I. Lone, PHOSP-COVID Study Collaborative Group Nature Medicine (August 2023)  Abstract Post-COVID cognitive deficits, including ‘brain fog’, are clinically complex, with both objective and […]