Inflammation is not merely a symptom—it is a biological imperative. It orchestrates the body’s defense against infection, injury, and metabolic imbalance. Yet when dysregulated, inflammation becomes a crucible for chronic […]
OPG and TNFR1 as Potential Biomarkers of Inflammation in Older Adults with Acute COVID-19
Ramon-Luing LA , Flores-Gonzalez J , Cataneo-Piña DJ, et. al., DOI https://doi.org/10.2147/JIR.S545926 Background: Older individuals are at high risk for severe COVID-19 and often experience geriatric syndromes as post-COVID-19 sequelae associated with inflammation. Osteoprotegerin (OPG) and Tumor […]
Post-Spike Syndrome and Spikeopathy: Central Mechanisms in Long COVID Pathophysiology
Author: John Murphy, President COVID 19 Long-haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), has emerged as a multifaceted syndrome affecting millions globally. While initial hypotheses […]
Neuroinflammatory and Glutamatergic Dysregulation in Long COVID: Treating Brain Fog, Confusion, and Depression
John Murphy, – President, COVID-19 Long-haul Foundation Pathophysiology of Long COVID Neurocognitive Sequelae Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), is increasingly recognized as a chronic, multisystemic condition […]
Endothelial Dysfunction and Spike Protein Persistence in Long COVID: Mechanisms, Vulnerabilities, and Clinical Evidence
Author: John Murphy, President, COVID-19 Long-haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), is characterized by persistent symptoms affecting multiple organ systems. Among its most compelling […]
Exploring the Link Between COVID-19 and Liver Abscess Formation
Ramlakhan S. Verma • Shailendra Pal Singh • Gaurav Mishra • Vikas K. Patel • Vipin Gupta, DOI: 10.7759/cureus.94136 Abstract Background Liver abscess is a potential concern among liver health complications. With severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) […]
Persistent Shadows: Depression, Long COVID, and the Future of Mental Health Care
Author: John Murphy Affiliation: COVID-19 Long-haul Foundation Abstract Long COVID has emerged as a multifaceted syndrome with profound neuropsychiatric consequences. Among its most persistent and disabling sequelae is depression, which […]
Corticosteroid Strategies in Long COVID: Evaluating Prednisone and Dexamethasone for Persistent Inflammation
John Murphy, The COVID 19 Long-haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), presents with a constellation of symptoms including fatigue, dyspnea, cognitive dysfunction, and systemic […]
Transcriptomic analysis reveals shared deregulated neutrophil responses in COVID-19 and idiopathic pulmonary fibrosis
Abstract Background Coronavirus disease 2019 (COVID-19) is a respiratory disease linked with deregulated immune responses, leading to hyperinflammation, acute respiratory distress syndrome, and pulmonary fibrosis, often with fatal outcomes. Neutrophils […]
Research reveals new clues to the mysteries of long COVID
Don Bell, University of Alabama Three groundbreaking studies pinpoint immune cells and proteins linked with the lingering condition — and suggest a possible cause. Immunologist Shokrollah Elahi led three recent […]