Category: Biomarkers

Dynamic Assessment of Hematological Parameters as Predictive Biomarkers for Disease Severity and Prognosis in COVID-19 Patients: A Longitudinal Study

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Aparna P. Patange • Jabbar V. Desai • Bhupal Pujari • Aparna Marwah • Animesh Dey, Published: July 01, 2024, DOI: 10.7759/cureus.63593  Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to substantial morbidity and mortality worldwide. Hematological abnormalities are common in COVID-19 patients and play a significant role in disease pathogenesis and prognosis. Objective: […]

First-Of-Its-Kind Study Explains Why Some People Don’t Get COVID-19

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JUN 20, 2024 – Authored by Marina Zhang via The Epoch Times  Researchers have discovered why some people remain uninfected by the COVID-19 virus—even after their nasal cavities are exposed to it. According to a recent study, these people have faster and more subtle immune responses than those who develop symptomatic COVID-19. “These findings shed […]

Systems Modeling Reveals Shared Metabolic Dysregulation and Novel Therapeutic Treatments in ME/CFS and Long COVID

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Gong-Hua Li, Feifei Han, Qing-Peng Kong, Wenzhong Xiao, doi: https://doi.org/10.1101/2024.06.17.599450 Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID are complex, multisystemic conditions that pose ongoing challenges to healthcare professionals. Emerging research suggests that ME/CFS and Long COVID exhibit overlapping metabolic symptoms, indicating possible shared metabolic dysfunctions. This study aims to systematically explore these shared metabolic disturbances and their potential treatments. Utilizing our […]

The blood holds clues to understanding long COVID

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The search for biomarkers could eventually lead scientists to tests and treatments By Meghan Rosen, MARCH 4, 2024 AT 9:00 AM Science News When I talk to immunologist Paul Morgan, he’s on the hunt for potentially life-altering drugs.  He’s got a call with a pharmaceutical company planned in the next half hour. His goal: persuade the company to […]

Retrospective Evaluation of Hematological Parameters in COVID-19 Patients: Insights From the Emergency Department

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Ahmed Jerah, May 28, 2024, DOI: 10.7759/cureus.61258 Cite this article as: Jerah A (May 28, 2024) Retrospective Evaluation of Hematological Parameters in COVID-19 Patients: Insights From the Emergency Department. Cureus 16(5): e61258. doi:10.7759/cureus.61258 Abstract Background: This retrospective study evaluated hematological parameters in coronavirus disease 2019 (COVID-19) patients to gain clinical insights. Methods: Data from the Emergency Department of Samtah […]

People with Long COVID Have Distinct Hormonal and Immune Differences From Those Without This Condition

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Research conducted at Mount Sinai and Yale confirms long COVID is a biological disease by showing blood biomarkers that can predict who has it (September 25, 2023) Nature Long COVID patients have clear differences in immune and hormone function from patients without the condition, according to a new study led by the Icahn School of […]

Long COVID: Is there a kidney link?

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Raymond E. Garrett, Carlos H. Palacio, David Bar-Or: HYPOTHESIS AND THEORY article, Front. Med., 03 April 2023, Sec. Nephrology, Volume 10 – 2023 | https://doi.org/10.3389/fmed.2023.1138644 Metabolic causes such as altered bioenergetics and amino acid metabolism may play a major role in Long COVID. Renal-metabolic regulation is an integral part of these pathways but has not been […]

Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization

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Maxime Taquet, Zuzanna Skorniewska, Adam Hampshire, James D. Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Olivia C. Leavy, Matthew Richardson, Omer Elneima, Hamish J. C. McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Ruth M. Saunders, Victoria C. Harris, Linzy Houchen-Wolloff, Neil J. Greening, Parisa Mansoori, Ewen M. Harrison, Annemarie B. Docherty, Nazir I. Lone, PHOSP-COVID Study Collaborative Group,  Nature Medicine (August 2023)  Abstract Post-COVID cognitive deficits, including ‘brain fog’, are clinically complex, with both objective and […]

SARS-CoV-2 particles promote airway epithelial differentiation and ciliation

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Julian Gonzalez-Rubio1 Vu Thuy Khanh Le-Trilling2 Lea Baumann1 Maria Cheremkhina1 Hannah Kubiza1 Anja E. Luengen1,3 Sebastian Reuter3 Christian Taube3 Stephan Ruetten4 Daniela Duarte Campos5 Christian G. Cornelissen1,6 Mirko Trilling2 Anja Lena Thiebes1, Front. Bioeng. Biotechnol., 02 November 2023 Sec. Tissue Engineering and Regenerative MedicineVolume 11 – 2023 | https://doi.org/10.3389/fbioe.2023.1268782 Introduction: The Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which caused the coronavirus disease 2019 (COVID-19) pandemic, enters the […]

Neurological manifestations of post-acute sequelae of COVID-19: which liquid biomarker should we use?

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Dominique Comeau1† Mykella Martin2† Gilles A. Robichaud3,4,5 Ludivine Chamard-Witkowski2,6*1Dr. Georges-L. Long COVID syndrome, also known as post-acute sequelae of COVID-19 (PASC), is characterized by persistent symptoms lasting 3–12 weeks post SARS-CoV-2 infection. Patients suffering from PASC can display a myriad of symptoms that greatly diminish quality of life, the most frequent being neuropsychiatric. Thus, there is an eminent need […]