Category: Brain

Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent Symptoms

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Authors: Amy D. Proal1 and Michael B. VanElzakker1,2* The novel virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic of coronavirus disease 2019 (COVID-19). Across the globe, a subset of patients who sustain an acute SARS-CoV-2 infection are developing a wide range of persistent symptoms that do not resolve over the course of many […]

The Impact of the Covid 19 Pandemic on Cerebrovascular Disease: CORD-Papers-2021-06-28

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Abstract:            Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a systemic disease that affects nearly all organ systems through infection and subsequent dysregulation of the vascular endothelium. One of the most striking phenomena has been a coronavirus disease 2019 (COVID-19)associated coagulopathy. Given these findings, questions naturally emerged about the prothrombotic impact of COVID-19 on cerebrovascular […]

The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology

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Authors:Jenny K.Stodola1GuillaumeDubois1AlainLe CoupanecMarcDesforgesPierre J.Talbot Highlights Coronavirus structural envelope (E) protein specific motifs involved in protein-protein interaction or in homo-oligomeric ion channel formation are needed for optimal production of recombinant infectious virus.• Fully functional E protein of HCoV-OC43 is crucial for viral propagation in the CNS and neurovirulence.• Fully functional E protein of HCoV-OC43 is crucial […]

Late Complications of COVID-19; a Systematic Review of Current Evidence

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Authors: SeyedAhmad SeyedAlinaghi,1Amir Masoud Afsahi,2Mehrzad MohsseniPour,1Farzane Behnezhad,3Mohammad Amin Salehi,1Alireza Barzegary,4Pegah Mirzapour,1Esmaeil Mehraeen,5,* and Omid Dadras6 Introduction Introduction: COVID-19 is a new rapidly spreading epidemic. The symptoms of this disease could be diverse as the virus can affect any organ in the body of an infected person. This study aimed to investigate the available evidence for long-term complications […]

Neurologic Features in Severe SARS-CoV-2 Infection

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Authors: Julie Helms, M.D., Ph.D., Stéphane Kremer, M.D., Ph.D., Hamid Merdji, M.D., Raphaël Clere-Jehl, M.D., Malika Schenck, M.D., Christine Kummerlen, M.D., Olivier Collange, M.D., Ph.D., Clotilde Boulay, M.D., Samira Fafi-Kremer, Pharm.D., Ph.D., Mickaël Ohana, M.D., Ph.D., Mathieu Anheim, M.D., Ph.D. Strasbourg University Hospital, Strasbourg, France, Ferhat Meziani, M.D., Ph.D.University of Strasbourg, Strasbourg, France Reported here […]

Bell’s Palsy after second dose of Pfizer COVID-19 vaccination in a patient with history of recurrent Bell’s palsy

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Authors: Michael Repajic,a Xue Lei Lai,a Prissilla Xu,b and Antonio Liua,∗ Abstract Objective To report a patient with history of recurrent Bell’s Palsy who developed Bell’s Palsy 36 ​h after the administration of the second dose of the Pfizer-BioNTech COVID-19 vaccine. Case The patient is a 57-year-old female with past medical history of 3 episodes of Bell’s Palsy. She responded […]

Bell’s palsy following COVID-19 vaccination

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Authors: Giuseppe Colella,1Massimiliano Orlandi,2 and Nicola Cirillo1,3 Currently two Coronavirus Disease 2019 (COVID-19) vaccines have been granted emergency use and marketing authorization by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) [1, 2]. Initial efficacy and safety data for both BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) vaccines have been published [3, 4]. To the best […]

SARS-CoV-2 mediated neuroinflammation and the impact of COVID-19 in neurological disorders

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Authors: Narayanappa Amruta,a Wesley H. Chastain,a Meshi Paz,a Rebecca J. Solch,b Isabel C. Murray-Brown,a Jaime B. Befeler,a Timothy E. Gressett,a Michele T. Longo,b,c Elizabeth B. Engler-Chiurazzi,a,c and Gregory Bixa,b,c,* Abstract SARS-CoV-2 is a novel coronavirus that severely affects the respiratory system, is the cause of the COVID-19 pandemic, and is projected to result in the deaths of 2 million people worldwide. Recent reports suggest that […]

Studies: COVID tied to persistent cognitive deficits in seniors

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Authors: Mary Van Beusekom | News Writer | CIDRAP News  | Jul 30, 2021 New studies show an association between COVID-19 and cognitive impairment in older patients, with one reporting memory problems and worse physical health 8 months after diagnosis and others finding cognitive decline and accelerated Alzheimer’s disease symptoms as long as 6 months after infection. […]

Insights into How SARS-CoV-2 Causes Brain Pathology

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Authors: Anthony L. Komaroff, MD, reviewing Yang AC et al. Nature 2021 Jul Marshall M. Nature 2021 Jul In deceased COVID-19 patients, gene expression in the choroid plexus was altered. People infected with SARS-CoV-2 can develop a wide variety of neurological conditions: Endothelial dysfunction can lead to ischemic and hemorrhagic strokes, even in young adults. Demyelinating diseases occur. Autoantibodies that […]