Category: Acute Respiratory Distress

Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people

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Julia Hippisley-Cox1, Duncan Young2,3, Carol Coupland4, Keith M Channon5, Pui San Tan6, David A Harrison7, Kathryn Rowan8,  Paul Aveyard6, Ian D Pavord9, Peter J Watkinson5,10 Correspondence to Prof Julia Hippisley-Cox, Primary Care Health Sciences, University of Oxford, Oxford OX1  Abstract Background  There is uncertainty about the associations of angiotensive enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) drugs with COVID-19 disease. We studied whether […]

Here’s what we know so far about the long-term symptoms ofCOVID-19

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July 26, 2020 3.56pm EDT We’re now all too familiar with the common symptoms of COVID-19: a fever, dry cough and fatigue. Some people also experience aches and pains, a sore throat, and loss of taste or smell. Sufferers with mild illness might expect to get better after a few weeks. But there’s mounting evidence this […]

How does coronavirus kill? Clinicians trace a ferocious rampage through the body, from brain to toes

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Authors: By Meredith Wadman, Jennifer Couzin-Frankel, Jocelyn Kaiser, Catherine MatacicApr. 17, 2020 , 6:45 PM On rounds in a 20-bed intensive care unit one recent day, physician Joshua Denson assessed two patients with seizures, many with respiratory failure and others whose kidneys were on a dangerous downhill slide. Days earlier, his rounds had been interrupted as his team tried, […]

Clinical determinants of the severity of COVID-19: A systematic review and meta-analysis

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Authors: Xinyang Li, Xianrui Zhong, Yongbo Wang, Xiantao Zeng, Ting Luo, Qing Liu  Published: May 3, 2021 Abstract Objective We aimed to systematically identify the possible risk factors responsible for severe cases. Methods We searched PubMed, Embase, Web of science and Cochrane Library for epidemiological studies of confirmed COVID-19, which include information about clinical characteristics […]

Coronavirus and the Nervous System

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What is SARS-CoV-2 and COVID-19? What do we know about the effects of SARS-CoV-2 and COVID-19 on the nervous system? What are the immediate (acute) effects of SARS-CoV-2/COVID-19 on the brain? What is the typical recovery from COVID-19? What are possible long-term neurological complications of COVID-19? How do the long-term effects of SARS-CoV-2 infection/COVID-19 relate […]

The characteristics and evolution of pulmonary fibrosis in COVID-19 patients as assessed by AI-assisted chest HRCT

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Authors: Jia-Ni Zou , Liu Sun , Bin-Ru Wang , You Zou , Shan Xu, Yong-Jun Ding, Li-Jun Shen, Wen-Cai Huang, Xiao-Jing Jiang, Shi-Ming Chen  Published: March 23, 2021 https://doi.org/10.1371/journal.pone.0248957 Abstract The characteristics and evolution of pulmonary fibrosis in patients with coronavirus disease 2019 (COVID-19) have not been adequately studied. AI-assisted chest high-resolution computed tomography (HRCT) was used to […]

Ivermectin to prevent hospitalizations in patients with COVID-19 (IVERCOR-COVID19) a randomized, double-blind, placebo-controlled trial

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Authors: Julio Vallejos, Rodrigo Zoni, María Gabriela Aguirre  Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has changed our lives. The scientific community has been investigating re-purposed treatments to prevent disease progression in coronavirus disease (COVID-19) patients. Objective To determine whether ivermectin treatment can prevent hospitalization in individuals with early COVID-19. Design, setting and participants: A […]

Hyperglycemia in Acute COVID-19 is Characterized by Adipose Tissue Dysfunction and Insulin Resistance

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Authors: Reiterer M, Rajan M, Gómez-Banoy N, Lau JD, Gomez-Escobar LG, Gilani A, Alvarez-Mulett S, Sholle ET, Chandar V, Bram Y, Hoffman K, Rubio-Navarro A, Uhl S, Shukla AP, Goyal P, tenOever BR, Alonso LC, Schwartz RE, Schenck EJ, Safford MM Abstract  COVID-19 has proven to be a metabolic disease resulting in adverse outcomes in individuals with diabetes or obesity. Patients infected with SARS-CoV-2 and hyperglycemia suffer from longer hospital stays, higher risk of […]

Severe COVID-19: what have we learned with the immunopathogenesis?

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Authors: Bruno Bordallo,  Mozart Bellas, Arthur Fernandes Cortez, Matheus Vieira & Marcelo Pinheiro  Advances in Rheumatology volume 60, Article number: 50 (2020) Cite this article Abstract The COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global major concern. In this review, we addressed a theoretical model on immunopathogenesis associated with severe COVID-19, based on the current literature of SARS-CoV-2 […]

Role of DAMPs in respiratory virus-induced acute respiratory distress syndrome—with a preliminary reference to SARS-CoV-2 pneumonia

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Review Article; Published: 17 June 2021 Authors: Walter Gottlieb Land Genes & Immunity volume 22, pages141–160 (2021 )Cite this article Abstract When surveying the current literature on COVID-19, the “cytokine storm” is considered to be pathogenetically involved in its severe outcomes such as acute respiratory distress syndrome, systemic inflammatory response syndrome, and eventually multiple organ failure. In this review, the […]