Complement Anaphylatoxins and Inflammatory Cytokines as Prognostic Markers for COVID-19 Severity and In-Hospital Mortality

August 6, 2021 | John Murphy | Leave a Comment

Complement Anaphylatoxins and Inflammatory Cytokines as Prognostic Markers for COVID-19 Severity and In-Hospital Mortality

Authors: Bandar Alosaimi1,2, Ayman Mubarak3, Maaweya E. Hamed3, Abdullah Z. Almutairi4, Ahmed A. Alrashed5, Abdullah AlJuryyan6, Mushira Enani7,Faris Q. Alenzi8 and Wael Alturaiki9* COVID-19 severity due to innate immunity dysregulation accounts for prolonged hospitalization, critical complications, and mortality.…[...]

July 30, 2021 | John Murphy | Leave a Comment

COVID-19 is, in the end, an endothelial disease

Authors: Peter Libby, Thomas Lüscher The vascular endothelium provides the crucial interface between the blood compartment and tissues, and displays a series of remarkable properties that normally maintain homeostasis. This tightly…[...]

July 30, 2021 | John Murphy | Leave a Comment

COVID-19 Vasculopathy: Mounting Evidence for an Indirect Mechanism of Endothelial Injury

Authors: Roberto F. Nicosia,∗∗ Giovanni Ligresti,† Nunzia Caporarello,‡ Shreeram Akilesh,∗ and Domenico Ribatti§ Patients with coronavirus disease 2019 (COVID-19) who are critically ill develop vascular complications characterized by thrombosis of small, medium, and large vessels.…[...]

July 30, 2021 | John Murphy | Leave a Comment

Endothelial dysfunction contributes to COVID-19-associated vascular inflammation and coagulopathy

Authors: Jun Zhang 1, Kristen M Tecson 1, Peter A McCullough 1 2 3 Great attention has been paid to endothelial dysfunction (ED) in coronavirus disease 2019 (COVID-19). There is growing evidence to suggest that the angiotensin…[...]

July 29, 2021 | John Murphy | Leave a Comment

What is cytokine release syndrome?

Authors: Medical News Today Cytokine release syndrome (CRS) can cause a variety of symptoms, including fever, headaches, and nausea. The symptoms can become severe quickly. CRS occurs when the immune system…[...]

July 28, 2021 | John Murphy | Leave a Comment

What Is a Cytokine Storm? Doctors Explain How Some COVID-19 Patients’ Immune Systems Turn Deadly

Authors: Sarah Bradley The news cycle is heavily saturated with stress-inducing information about COVID-19, but one of the most worrying aspects so far has been the huge disparity in the way the novel…[...]

July 28, 2021 | John Murphy | Leave a Comment

Cytokine Storm in COVID-19—Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper

Authors: Sonu Bhaskar,1,2,3,* Akansha Sinha,1,4 Maciej Banach,1,5,6,7 Shikha Mittoo,1,8 Robert Weissert,1,9 Joseph S. Kass,1,10 Santhosh Rajagopal,1,11 Anupama R. Pai,1,12 and Shelby Kutty1,13,14 Cytokine storm is an acute hyperinflammatory response that may be responsible for critical illness in many conditions…[...]

July 28, 2021 | John Murphy | Leave a Comment

COVID-19 cytokine storm: The anger of inflammation

Authors: Mehdi Mahmudpour 1, Jamshid Roozbeh 2, Mohsen Keshavarz 1, Shokrollah Farrokhi 3, Iraj Nabipour 4 Patients with COVID-19 who require ICU admission might have the cytokine storm. It is a state of out-of-control release of a variety of…[...]

July 28, 2021 | John Murphy | Leave a Comment

Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies

Authors: Yujun Tang,† Jiajia Liu,† Dingyi Zhang, Zhenghao Xu, Jinjun Ji,* and Chengping Wen* Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the pathogen that causes coronavirus disease 2019 (COVID-19). As of 25 May 2020, the…[...]

July 28, 2021 | John Murphy | Leave a Comment

SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

Authors: Víctor J Costela-Ruiz 1, Rebeca Illescas-Montes 1, Jose M Puerta-Puerta 2, Concepción Ruiz 3, Lucia Melguizo-Rodríguez 1 COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of…[...]