I. Persistent Cytokine-Driven Inflammatory Signaling I.A. IL-6–Centered Inflammatory Axis Interleukin-6 (IL-6) has emerged as one of the most consistently elevated cytokines in Long COVID cohorts, serving as a central node […]
SARS-CoV-2–Associated Injury to Human Epithelial Tissues
Authors: John Murphy, M.D., MPH, DPH. ,Affiliations: President COVID-19 Long-haul FoundationAbstract: 250 words Abstract BackgroundSARS-CoV-2 infection produces multisystem disease with prominent epithelial involvement extending beyond the respiratory tract. Increasing evidence […]
Study Shows Structural Differences In COVID Patients Months After Infection, Even Among Those Who ‘Feel Fine’
In A Nutshell Brain scans of people who had COVID-19 show differences in brain structure months after infection, according to a small study from Australia. Even people who feel fully […]
You Recovered From COVID, But Did Your Brain? New Scans Raise Questions
Research led by Kiran Thapaliya (Griffith University) Study Shows Structural Differences In COVID Patients Months After Infection, Even Among Those Who ‘Feel Fine’ In A Nutshell Brain scans of people […]
The Motor Neuron Disease Spectrum
John Murphy, M.D., MPH, DPH, President The Covid-19 Long-haul Foundation Abstract Motor neuron diseases (MNDs) comprise a heterogeneous spectrum of neurodegenerative and immune-mediated disorders characterized by selective vulnerability of upper […]
Post–COVID-19 Immune Dysregulation and the Emergence of Methicillin-Resistant Staphylococcus aureus
John Murphy, M.D., MPH, DPH, President COVID-19 Long-haul Foundation Abstract The coronavirus disease 2019 (COVID‑19) pandemic has reshaped the global landscape of infectious diseases in ways that extend far beyond […]
Long COVID and Speech-Language Pathology: Etiology, Pathology, Clinical Observations, Progression, Treatment, and Prognosis
John Murphy, M.D., MPH, DPH, President COVID-19 Long-haul Foundation Abstract Long COVID—also called post-COVID-19 condition or post-acute sequelae of SARS-CoV-2 infection (PASC)—is a multisystem disorder that commonly produces persistent neurological, […]
Energy depletion in long-COVID: etiology, physiology, pathology, and clinical findings of exhaustion
John Murphy, M.D., MPH, DPH, President COVID-19 Long-haul Foundation Abstract Persistent, debilitating fatigue and exertional intolerance are among the most frequent and disabling features of post-acute sequelae of SARS-CoV-2 infection […]
Mitochondrial Depletion and Long-COVID: Etiology, Pathophysiology, Diagnostics, and Clinical Implications
John Murphy, M.D., MPH, D.P.H., President The COVID19 Long-haul Foundation AbstractA growing body of evidence implicates mitochondrial dysfunction — including depletion of mitochondrial DNA (mtDNA), loss of mitochondrial membrane potential, […]
FDA intends to put its most serious warning on Covid vaccines, sources say
By Ben Tinker, Brenda Goodman, Meg Tirrell, CNN The US Food and Drug Administration intends to put a “black box” warning on Covid-19 vaccines, according to two people familiar with […]