Etiology, pathology, genomics, physiology, and clinical course Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), is a heterogeneous multisystem disorder in which fatigue, post-exertional malaise, cognitive dysfunction, autonomic […]
Multidisciplinary Care Pathways for Long COVID Fatigue:
A Systems-Based Model Integrating Rehabilitation Medicine, Neuroimmunology, Autonomic Care, and Precision Phenotyping Abstract Background Long COVID, also referred to as post-acute sequelae of SARS-CoV-2 infection (PASC), has emerged as one […]
Persistent SARS-CoV-2 Reservoirs and the Pathobiology of Long COVID
Etiology, Tissue Persistence, Genomics, Clinical Manifestations, Biomarkers, and Emerging Therapeutic Strategies John Murphy, Chief Executive Officer, The COVID-19 Long-haul Foundation Abstract Background More than four years after the emergence of […]
COVID-19 and Cerebral Microclots: Their Role in Persistent Neurological Dysfunction, Cognitive Impairment, and Long COVID
Review Article John Murphy, CEO, COVID-19 Long haul Foundation Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is increasingly recognized as a multisystem vascular disease […]
Long COVID and Renal Disease: Pathophysiology, Genomics, Clinical Manifestations, and Long-Term Implications
Abstract Long coronavirus disease (Long COVID, post-acute sequelae of SARS-CoV-2 infection [PASC]) has emerged as a major chronic health challenge affecting multiple organ systems. Although pulmonary, cardiovascular, and neurologic manifestations […]
Recognition of Long COVID as a Heterogeneous Post-Infectious Syndrome
Toward a Multisystem Endotype Framework for Post–Acute SARS-CoV-2 Disease John Murphy, M.D., M.P.H., D.P.H. President Covid-19 Long-haul Foundation Abstract Long COVID (post–acute sequelae of SARS-CoV-2 infection, PASC) has emerged as […]
Treatment Landscape in Long COVID Has Expanded Beyond “Supportive Care”
A Mechanism-Driven Reframing of Therapeutic Development in Post–Acute SARS-CoV-2 Disease John Murphy, M.D, M.P.H., D.P.H. President COVID Long-haul Foundation Conceptual Shift and Therapeutic Reclassification ABSTRACT For much of the early […]
Persistent Viral Reservoirs and Immune Dysregulation in Long COVID
John Murphy, M.D., M.P.H., D.P.H., President Covid-19 Long-haul Foundation The Central Discovery Reshaping Post-Acute Sequelae Research Abstract Long COVID (post-acute sequelae of SARS-CoV-2 infection, PASC) has emerged as a multisystem […]
Energy depletion in long-COVID: etiology, physiology, pathology, and clinical findings of exhaustion
John Murphy, M.D., MPH, DPH, President COVID-19 Long-haul Foundation Abstract Persistent, debilitating fatigue and exertional intolerance are among the most frequent and disabling features of post-acute sequelae of SARS-CoV-2 infection […]
The Lingering Pandemic: Mapping the Arc of Long COVID and the Search for Recovery
By John Murphy, The COVID 19 Long-haul Foundation Introduction: A Pandemic That Didn’t End When the world first confronted SARS-CoV-2 in early 2020, the prevailing narrative was one of acute […]