The COVID-19 Long Haul Foundation

Treatment, Referral & Educational Support for COVID-19 Illnesses & Vaccine Injury

Brain Fog / Endothelium / Exercise Intolerance / Fatigue / Immune System / Long COV / Long-haul Disease / Mitochondria / Mitochondrial dysfunction / Palpitations / PASC / Post-infectious Syndrome / T-cell Posted on:

Recognition of Long COVID as a Heterogeneous Post-Infectious Syndrome

Toward a Multisystem Endotype Framework for Post–Acute SARS-CoV-2 Disease John Murphy, M.D., M.P.H., D.P.H. President Covid-19 Long-haul Foundation Abstract Long COVID (post–acute sequelae of SARS-CoV-2 infection, PASC) has emerged as […]

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Dysautonomia / Endothelium / Immune System / Inflammation / Mitochondria / Mitochondrial dysfunction / Mitochondrial Effects / Treatments Posted on:

Treatment Landscape in Long COVID Has Expanded Beyond “Supportive Care”

A Mechanism-Driven Reframing of Therapeutic Development in Post–Acute SARS-CoV-2 Disease John Murphy, M.D, M.P.H., D.P.H. President COVID Long-haul Foundation Conceptual Shift and Therapeutic Reclassification ABSTRACT For much of the early […]

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Autonomic nervous system disruption / Brain / Cognitive deficit / Cytokine Storm / Endothelium / Fatigue / Hyperinflammation / Inflammasome / Inflammation / Inflammation / Microvascular damage / Mitochondria / Mitochondrial dysfunction / Mitochondrial Effects / Neuropathy Posted on:

Persistent Viral Reservoirs and Immune Dysregulation in Long COVID

John Murphy, M.D., M.P.H., D.P.H., President Covid-19 Long-haul Foundation The Central Discovery Reshaping Post-Acute Sequelae Research Abstract Long COVID (post-acute sequelae of SARS-CoV-2 infection, PASC) has emerged as a multisystem […]

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Chalder Fatigue Scale / Chronic Fatigue / Chronic Fatigue Syndrome / Cytokine Storm / Fatigue / Fatigue / IFN-γ / Malaise-Fatigue / Mitochondrial depletion / Mitochondrial dysfunction / Mitochondrial Effects / Oxydative stress Posted on:

Energy depletion in long-COVID: etiology, physiology, pathology, and clinical findings of exhaustion

John Murphy, M.D., MPH, DPH, President COVID-19 Long-haul Foundation Abstract Persistent, debilitating fatigue and exertional intolerance are among the most frequent and disabling features of post-acute sequelae of SARS-CoV-2 infection […]

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Autonomic nervous system disruption / Chronic Fatigue / Fatigue / Immune dysregulation / Long-haul Disease / Malaise-Fatigue / ME/CFS / Microvascular damage / Mitochondrial dysfunction / Viral persistence Posted on:

The Lingering Pandemic: Mapping the Arc of Long COVID and the Search for Recovery

By John Murphy, The COVID 19 Long-haul Foundation Introduction: A Pandemic That Didn’t End When the world first confronted SARS-CoV-2 in early 2020, the prevailing narrative was one of acute […]

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Circadian Rhythm / Cortisol / Glymphatic system / Melatonin / Mitochondrial dysfunction / Narcolepsy / Sleep & Dreams / Sleep Deprivation / Sleep Disturbance Posted on:

🧠 Long COVID and Sleep Disorders: Mechanisms, Brain Centers, and Therapeutic Advances (2025 Review)

Sleep disturbances have emerged as one of the most persistent and disruptive symptoms of Long COVID, affecting up to 40–76% of patients months after infection2. This article synthesizes 2025 peer-reviewed […]

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Acute tubular injury (ATI) / Mitochondria / Mitochondrial dysfunction / Mitochondrial Effects / Renal tubular cells / Spike Protein Posted on:

🧪 COVID Spike Protein and Kidney Damage: Stage 3B Illness, Fluid Retention, and Electrolyte Recovery

As research into Long COVID and post-vaccination syndromes deepens, 2025 peer-reviewed studies have identified a troubling link between spike protein persistence and kidney damage, particularly in patients progressing to Stage […]

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