COVID‐19‐induced endotheliitis: emerging evidence and possible therapeutic strategies

February 3, 2022 | John Murphy | Leave a Comment

COVID‐19‐induced endotheliitis: emerging evidence and possible therapeutic strategies

Authors: Eleonora Calabretta, 1 , 12 Jose M. Moraleda, 2 Massimo Iacobelli, 3 Ruben Jara, 4 Israel Vlodavsky, 5 Peter O’Gorman, 6 Antonio Pagliuca, 7 Clifton Mo, 8 Rebecca M. Baron, 9 Alessio Aghemo, 10 , 12 Robert Soiffer, 8 Jawed Fareed, 11 Carmelo Carlo‐Stella, 1 , 12 , * and Paul Richardson 8 , * Br J Haematol. 2021 Apr; 193(1): 43–51.Published online…[...]

January 30, 2022 | John Murphy | Leave a Comment

Close relatives of MERS-CoV in bats use ACE2 as their functional receptors

Authors: Qing Xiong, View ORCID , , ei Cao, Chengbao Ma, Chen Liu, Junyu Si, Peng Liu, Mengxue Gu, Chunli Wang, Lulu Shi, Fei Tong, Meiling Huang, Jing Li, Chufeng Zhao, Chao Shen, Yu Chen, Huabin Zhao, Ke Lan, Xiangxi Wang, Huan Yan Summary Middle East Respiratory Syndrome coronavirus (MERS-CoV) and several bat coronaviruses employ Dipeptidyl peptidase-4 (DPP4) as…[...]

January 28, 2022 | John Murphy | Leave a Comment

Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs

Authors: Taejoon Won, Megan K. Wood, David M. Hughes, Monica V. Talor, Zexu MaJowaly Schneider, et al. Published:January 12, 2022DOI:https://doi.org/10.1016/j.ebiom.2022.103812 Background Thromboembolism is a life-threatening manifestation of coronavirus disease 2019…[...]

January 28, 2022 | John Murphy | Leave a Comment

Elevated Expression of Serum Endothelial Cell Adhesion Molecules in COVID-19 Patients

Authos: Ming Tong,1Yu Jiang,2Da Xia,3Ying Xiong,3Qing Zheng,4Fang Chen,2Lianhong Zou,2Wen Xiao,2 and Yimin Zhu2 J Infect Dis. 2020 Sep 15; 222(6): 894–898.Published online 2020 Jun 24. doi: 10.1093/infdis/jiaa349 PMCID: PMC7337874PMID: 32582936 Abstract In a retrospective study of 39…[...]

January 27, 2022 | John Murphy | Leave a Comment

What Role does Endothelial Infection Play in SARS-CoV-2 Infection?

Authors: By Dr. Liji Thomas, MD Reviewed by Emily Henderson, B.Sc. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause inflammatory lung disease, including clot formation and hyper-permeability of the lung…[...]

January 27, 2022 | John Murphy | Leave a Comment

Spike Proteins, COVID-19, and Vaccines

A new study further elucidates the role of spike proteins in COVID-19. Authors: Steven Novella May 5, 2021 A recent study looks at the effects of the SARS-CoV-2 spike proteins, showing…[...]

January 21, 2022 | John Murphy | Leave a Comment

The novel coronavirus’ spike protein plays additional key role in illness

Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease April 30, 2021 LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive…[...]

January 20, 2022 | John Murphy | Leave a Comment

Domains and Functions of Spike Protein in SARS-Cov-2 in the Context of Vaccine Design

Authors: Xuhua Xia1,2Kenneth Lundstrom, Academic Editor and Alaa. A. A. Aljabali, Academic Editor Abstract The spike protein in SARS-CoV-2 (SARS-2-S) interacts with the human ACE2 receptor to gain entry into a cell to…[...]

January 20, 2022 | John Murphy | Leave a Comment

Long-Term Dangers Of Experimental mRNA Shots

Authors: Analysis by Dr. Joseph Mercola STORY AT-A-GLANCE mRNA-based COVID shots have used codon optimization to improve protein production. A codon consists of three nucleotides, and nucleotides are the building blocks…[...]

January 14, 2022 | John Murphy | Leave a Comment

SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro

Authors: Hui Jiang1,2,* and Ya-Fang Mei2,* Viruses. 2021 Oct; 13(10): 2056.Published online 2021 Oct 13. doi: 10.3390/v13102056 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the coronavirus disease 2019 (COVID–19) pandemic, severely…[...]