Authors: Luís Lourenço Graça ,1 Maria João Amaral ,2 Marco Serôdio,3 Beatriz Costa2 SUMMARYA 62-year-old Caucasian female patient presented with abdominal pain, vomiting and fever 1 day after administration of […]
Intestinal Damage in COVID-19: SARS-CoV-2 Infection and Intestinal Thrombosis
Authors: Xiaoming Wu1, Haijiao Jing1, Chengyue Wang1, Yufeng Wang1, Nan Zuo1, Tao Jiang2*, Valerie A. Novakovic3 and Jialan Shi1,3,4* Front. Microbiol., 22 March 2022 | https://doi.org/10.3389/fmicb.2022.860931 The intestinal tract, with high expression of angiotensin-converting enzyme 2 (ACE2), is a […]
Review of Mesenteric Ischemia in COVID-19 Patients
Authors: Amit Gupta, Oshin Sharma, Kandhala Srikanth, Rahul Mishra, Amoli Tandon & Deepak Rajput Indian Journal of Surgery (2022) Published: 11 March 2022 Abstract The new coronavirus (COVID-19) infection, first detected in Wuhan, China in 2019 has become […]
Uptake of SARS-CoV-2 spike protein in human cerebrovascular cells
Authors: Bhavana Kunkalikar Mar 24 2022 Reviewed by Danielle Ellis, B.Sc. BioRxiv A recent study posted to the bioRxiv* preprint server assessed the uptake of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) […]
Study evaluates mutation-induced SARS-CoV-2 spike protein fold stability
Authors: Tarun Sai Lomte Mar 24 2022 BioRxiv In a recent study posted to the bioRxiv* preprint server, researchers evaluated the stability and expression of mutations in the spike (S) protein […]
ACE2-independent infection of T lymphocytes by SARS-CoV-2
Authors: Xu-Rui Shen, Rong Geng, Qian Li, Ying Chen, Shu-Fen Li, Qi Wang, Juan Min, Yong Yang, Bei Li, Yong Yang, Bei Li, Ren-Di Jiang, Xi Wang, Xiao-Shuang Zheng, Yan Zhu, Jing-Kun Jia, Xing-Lou Yang, Mei-Qin Liu, Qian-Chun Gong, Yu-Lan Zhang, Zhen-Qiong Guan, Hui-Ling Li, Zhen-Hua Zheng, Zheng-Li Shi, Hui-Lan Zhang, Ke Peng & Peng Zhou […]
The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling
Authors: Juan Pablo Robles 1Magdalena Zamora 1Elva Adan-CastroLourdes Siqueiros-MarquezGonzalo Martinez de la EscaleraCarmen Clapp Open AccessDOI:https://doi.org/10.1016/j.jbc.2022.101695 Vascular endothelial cells (ECs) form a critical interface between blood and tissues that maintains whole-body homeostasis. […]
COVID‐19‐induced endotheliitis: emerging evidence and possible therapeutic strategies
Authors: Eleonora Calabretta, 1 , 12 Jose M. Moraleda, 2 Massimo Iacobelli, 3 Ruben Jara, 4 Israel Vlodavsky, 5 Peter O’Gorman, 6 Antonio Pagliuca, 7 Clifton Mo, 8 Rebecca M. Baron, 9 Alessio Aghemo, 10 , 12 Robert Soiffer, 8 Jawed Fareed, 11 Carmelo Carlo‐Stella, 1 , 12 , * and Paul Richardson 8 , * Br J Haematol. 2021 Apr; 193(1): 43–51.Published online […]
Close relatives of MERS-CoV in bats use ACE2 as their functional receptors
Authors: Qing Xiong, View ORCID , , ei Cao, Chengbao Ma, Chen Liu, Junyu Si, Peng Liu, Mengxue Gu, Chunli Wang, Lulu Shi, Fei Tong, Meiling Huang, Jing Li, Chufeng Zhao, Chao Shen, Yu Chen, Huabin Zhao, Ke Lan, Xiangxi Wang, Huan Yan Summary Middle East Respiratory Syndrome coronavirus (MERS-CoV) and several bat coronaviruses employ Dipeptidyl peptidase-4 (DPP4) as […]