Category: Thromboembolism

SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation

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Authors: Luca Perico 1, Marina Morigi 1, et. al.; 2022 Mar 7;13:827146. doi: 10.3389/fimmu. 2022.827146. eCollection 2022. Abstract Microvascular thrombosis is associated with multiorgan failure and mortality in coronavirus disease 2019 (COVID-19). Although thrombotic complications may be ascribed to the ability of SARS-CoV-2 to infect and replicate in endothelial cells, it has been poorly investigated whether, in the complexity of viral […]

Doxycycline’s Potential Role in Reducing Thrombosis and Mortality in Critically Ill Patients With COVID-19: A Multicenter Cohort Study

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Khalid Al Sulaiman, MBA, BCCCP, BCNSP, FCCM https://orcid.org/0000-0002-5547-2043,  Ohoud Aljuhani, PharmD, […], and Ghassan Alghamdi, MD Abstract Doxycycline has revealed potential effects in animal studies to prevent thrombosis and reduce mortality. However, less is known about its antithrombotic role in patients with COVID-19. Our study aimed to evaluate doxycycline’s impact on clinical outcomes in critically ill patients with COVID-19. A multicenter retrospective cohort study […]

Diagnosis of venous thromboembolic diseases in people with covid-19: summary of updated NICE guidance

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BMJ 2023; 383 doi: https://doi.org/10.1136/bmj.p2204 (Published 12 October 2023)Cite this as: BMJ 2023;383:p2204, Sarah Boyce, senior technical analyst1,  Emma McFarlane, Susan Harrison, Terry McCormack What you need to know In venous thromboembolism, a blood clot usually forms in the deep veins of the legs or pelvis. This is known as deep vein thrombosis, and the blood clot can dislodge from these sites, […]