Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition

August 6, 2021 | John Murphy | Leave a Comment

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition

Authors: Jia Yu, Xuan Yuan, Hang Chen, Shruti Chaturvedi, Evan M. Braunstein, Robert A. Brodsky Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious respiratory virus that can lead to venous/arterial thrombosis, stroke,…[...]

July 30, 2021 | John Murphy | Leave a Comment

COVID-19 is, in the end, an endothelial disease

Authors: Peter Libby, Thomas Lüscher The vascular endothelium provides the crucial interface between the blood compartment and tissues, and displays a series of remarkable properties that normally maintain homeostasis. This tightly…[...]

July 30, 2021 | John Murphy | Leave a Comment

Endothelial dysfunction contributes to COVID-19-associated vascular inflammation and coagulopathy

Authors: Jun Zhang 1, Kristen M Tecson 1, Peter A McCullough 1 2 3 Great attention has been paid to endothelial dysfunction (ED) in coronavirus disease 2019 (COVID-19). There is growing evidence to suggest that the angiotensin…[...]