Category: Diffuse Alveolar Damage

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

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Authors.Maximilian Ackermann, M.D., Stijn E. Verleden, Ph.D., Mark Kuehnel, Ph.D., Axel Haverich, M.D., Tobias Welte, M.D., Florian Laenger, M.D., Arno Vanstapel, Ph.D., Christopher Werlein, M.D., Helge Stark, Ph.D., Alexandar Tzankov, M.D., William W. Li, M.D., Vincent W. Li, M.D., et al. July 9, 2020 N Engl J Med 2020; 383:120-128 DOI: 10.1056/NEJMoa2015432 Abstract BACKGROUND Progressive respiratory failure is the primary cause of death in the coronavirus disease […]

Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs

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Authors: Taejoon Won, Megan K. Wood, David M. Hughes, Monica V. Talor, Zexu Ma Jowaly Schneider, et al. Published:January 12, 2022DOI:https://doi.org/10.1016/j.ebiom.2022.103812 Background Thromboembolism is a life-threatening manifestation of coronavirus disease 2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells in the lungs during COVID-19. Methods We obtained the lung specimens from the patients […]

Pathological findings in organs and tissues of patients with COVID-19: A systematic review

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Authors: Sasha Peiris 1 2, Hector Mesa 3, Agnes Aysola 4, Juan Manivel 5, Joao Toledo 1 2, Marcio Borges-Sa 6, Sylvain Aldighieri 1 2, Ludovic Reveiz 2 7 Abstract Background: Coronavirus disease (COVID-19) is the pandemic caused by SARS-CoV-2 that has caused more than 2.2 million deaths worldwide. We summarize the reported pathologic findings on biopsy and autopsy in patients with severe/fatal COVID-19 and documented the presence and/or effect of SARS-CoV-2 in all organs. […]