Abstract Long coronavirus disease (Long COVID, post-acute sequelae of SARS-CoV-2 infection [PASC]) has emerged as a major chronic health challenge affecting multiple organ systems. Although pulmonary, cardiovascular, and neurologic manifestations […]
Viral Persistence and Tissue Reservoirs in SARS-CoV-2 Infection: Implications for Long COVID
John Murphy, CEO The COVID-19 Long-haul Foundation Introduction The unprecedented global spread of COVID-19 initiated one of the most intensive scientific investigations in modern medical history. While the acute phase […]
The Molecular Genomics of SARS-CoV-2: An Integrated Multi-Omics Perspective on Viral Evolution, Genome Organization, Replication, Host Interaction, and Systems Biology
John Murphy, CEO The COVID19 Long-haul Foundation Abstract The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) fundamentally transformed modern virology, molecular genetics, systems biology, structural biology, immunology, and […]
Plasma proteomic profile reveals persistent immune activation in post-acute sequelae of SARS-CoV-2 infection
Abstract Plasma proteomic profiling of 92 individuals with Post-Acute Sequelae of SARS-CoV-2 infection (PASC), assessed a mean of 34 months after acute infection, revealed a distinct inflammatory signature. Using proximity […]
🧠 Neurovascular Dysregulation and Microclot Persistence in COVID-19 Long-Haul Illnesses
Author: John Murphy, President, COVID-19 Long-haul Foundation 📑 Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), affects millions globally and presents with persistent symptoms including fatigue, cognitive dysfunction, […]
Long COVID continues to stick around. Scientists may finally know why
The Conversation, Research led by Brendan Crabb, Gabriela Khoury, and Michelle Scoullar, Burnet Institute Around 5–10% of people with COVID infections go on to experience long COVID, with symptoms lasting three months […]
The Lingering Pandemic: Mapping the Arc of Long COVID and the Search for Recovery
By John Murphy, The COVID 19 Long-haul Foundation Introduction: A Pandemic That Didn’t End When the world first confronted SARS-CoV-2 in early 2020, the prevailing narrative was one of acute […]
Long COVID continues to stick around. Scientists may finally know why
By The Conversation, Research led by Brendan Crabb, Gabriela Khoury, and Michelle Scoullar, Burnet Institute Around 5–10% of people with COVID infections go on to experience long COVID, with symptoms lasting three months […]
Mysterious Driving Factor Behind Long COVID May Have Been Identified
ByBrendan Crabb, The Conversation Around 5–10% of people with COVID infections go on to experience long COVID, with symptoms lasting three months or more. Researchers have proposed several biological mechanisms to explain long COVID. However, in […]
The Impact of Viral Load on the Severity and Outcome Among Patients With COVID-19: A Cross-Sectional Study
Fatma M. Shire • Shatha Sharbatti • Firas AlNajjar et. al.Published: July 09, 2024, DOI: 10.7759/cureus.64137 Abstract Objectives This study aimed to assess the relationship between illness severity and mortality among COVID-19 patients along with the cycle threshold […]