Category: Cytokine Storm

Alteration of the blood-brain barrier by COVID-19 and its implication in the permeation of drugs into the brain

Posted on | Posted on John Murphy | Leave a Comment on Alteration of the blood-brain barrier by COVID-19 and its implication in the permeation of drugs into the brain

Héctor Hernández-Parra1,2 Octavio Daniel Reyes-Hernández3 Gabriela Figueroa-González4 Manuel González-Del Carmen5 Maykel González-Torres6 Sheila I. Peña-Corona2 Benjamín Florán7 Hernán Cortés8* Gerardo Leyva-Gómez2* https://pubmed.ncbi.nlm.nih.gov/36998270/ Diverse neurological symptoms have been reported in patients with SARS-CoV-2 disease (COVID-19), including stroke, ataxia, meningitis, encephalitis, and cognitive impairment. These alterations can cause serious sequelae or death and are associated with the entry of SARS-CoV-2 into the Central Nervous System […]

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

Posted on | Posted on John Murphy | Leave a Comment on Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

Suo-wen Xu, Iqra Ilyas & Jian-ping Weng Acta Pharmacologica Sinica volume 44, pages695–709 (2023) Nature Abstract The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However, the pathophysiology of acute and post-acute manifestations of COVID-19 (long COVID-19) is understudied. Endothelial cells are sentinels lining the innermost layer of blood vessel that gatekeep micro- and macro-vascular health by […]

Biodistribution of mRNA COVID-19 vaccines in human breast milk

Posted on | Posted on John Murphy | Leave a Comment on Biodistribution of mRNA COVID-19 vaccines in human breast milk

Nazeeh Hanna, Claudia Manzano De Mejia, Ari Heffes-Doon, Xinhua Lin, Bishoy Botros, Ellen Gurzenda, et al. September 19, 2023 DOI:https://doi.org/10.1016/j.ebiom.2023.104800 Summary Background COVID-19 mRNA vaccines play a vital role in the fight against SARS-CoV-2 infection. However, lactating women have been largely excluded from most vaccine clinical trials. As a result, limited research has been conducted […]

Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer–BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines 

Posted on | Posted on John Murphy | Leave a Comment on Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer–BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines 

Sandhya Bansal, Sudhir Perincheri, Timothy Fleming,Christin Poulson, Brian Tiffany, Ross M. Bremner;Thalachallour Mohanakumar Author & Article Information J Immunol (2021) 207 (10): 2405–2410. https://doi.org/10.4049/jimmunol.2100637 Abstract Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) causes severe acute respiratory syndrome. mRNA vaccines directed at the SARS-CoV-2 spike protein resulted in development of Abs and protective immunity. To determine the mechanism, we analyzed […]

What to Know About ADHD and Brain Fog

Posted on | Posted on John Murphy | Leave a Comment on What to Know About ADHD and Brain Fog

Attention deficit hyperactivity disorder (ADHD) can have a big impact on your ability to think clearly. In fact, ADHD can sometimes make you feel as though a fog has seeped into your brain. Your reaction time slows. It can be harder to recall information, process your thoughts, and find the right words to say what […]

Potential Prophylactic Treatments for COVID-19

Posted on | Posted on John Murphy | Leave a Comment on Potential Prophylactic Treatments for COVID-19

Noam Ben-Zuk,1,† Ido-David Dechtman,2,3,† Itai Henn,1 Libby Weiss,1 Amichay Afriat,4 Esther Krasner,1,* and Yoav Gal1,5,*Kenneth Lundstrom, Academic Editor and Alaa A. A. Aljabali, Academic Editor Viruses. 2021 Jul; 13(7): 1292. Published online 2021 Jul 2. doi: 10.3390/v13071292 PMCID: PMC8310088 PMID: 34372498 Abstract The World Health Organization declared the SARS-CoV-2 outbreak a Public Health Emergency of International Concern at the end of January 2020 and a pandemic two months later. The […]

COVID-19 inflammation results in urine cytokine elevation and causes COVID-19 associated cystitis (CAC)

Posted on | Posted on John Murphy | Leave a Comment on COVID-19 inflammation results in urine cytokine elevation and causes COVID-19 associated cystitis (CAC)

Authrs: Laura E Lamb 1, Nivedita Dhar 2, Ryan Timar 3, Melissa Wills 3, Sorabh Dhar 4 PMID: 33213997PMCID: PMC7644255DOI: 10.1016/j.mehy.2020.110375 Abstract Coronavirus disease 2019 (COVID-19) causes a wide range of symptoms, including several unexpected symptoms such as loss of taste, skin changes, and eye problems. We recently observed patients with documented COVID-19 develop de novo severe genitourinary symptoms, most notably urinary frequency of ≥ 13 episodes/24 […]

COVID-19 inflammation results in urine cytokine elevation and causes COVID-19 associated cystitis (CAC)

Posted on | Posted on John Murphy | Leave a Comment on COVID-19 inflammation results in urine cytokine elevation and causes COVID-19 associated cystitis (CAC)

Authors: Laura E Lamb 1, Nivedita Dhar 2, Ryan Timar 3, Melissa Wills 3, Sorabh Dhar 4, Michael B Chancellor 5 PMID: 33213997 PMCID: PMC7644255 DOI: 10.1016/j.mehy.2020.110375 Abstract Coronavirus disease 2019 (COVID-19) causes a wide range of symptoms, including several unexpected symptoms such as loss of taste, skin changes, and eye problems. We recently observed patients with documented COVID-19 develop de novo severe genitourinary symptoms, most notably urinary frequency […]

How COVID-19 causes neurological damage found

Posted on | Posted on John Murphy | Leave a Comment on How COVID-19 causes neurological damage found

Particularly in the group with the most serious neurological symptoms, the researchers identified a link with an excessive immune response. Authors: PTI 15th November 2022 The Indian Express COVID-19 may cause damage to the nervous system, even though it does not affect nerve cells, according to a small study. While it was not uncommon for […]

Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection

Posted on | Posted on John Murphy | Leave a Comment on Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection

Authors: Chansavath Phetsouphanh, David R. Darley, Daniel B. Wilson, Annett Howe, C. Mee Ling Munier, Sheila K. Patel, Jennifer A. Juno, Louise M. Burrell, Stephen J. Kent, Gregory J. Dore, Anthony D. Kelleher & Gail V. Matthews  Nature Immunology volume 23, pages210–216 (2022) June 30, 2022 Nature Immunology volume 23, pages210–216 (2022) Abstract A proportion of patients surviving acute coronavirus disease 2019 (COVID-19) infection develop post-acute COVID syndrome (long COVID (LC)) lasting longer […]