COVID-19: Sleep, Circadian Rhythms and Immunity – Repurposing Drugs and Chronotherapeutics for SARS-CoV-2


Allan Giri,Ashokkumar SrinivasanIsaac Kirubakaran Sundar*, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, United States The severe acute…[...]

Sleep Disturbances Are Highly Prevalent Among People With Long COVID


Black race, COVID-19 hospitalization and mood symptoms confer increased risk, study finds Moderate to severe sleep disturbances are highly prevalent among patients with post-acute sequelae of COVID-19 (PASC), or “long…[...]

The first major set of genetic associations found in long COVID


PrecisionLife’s Dr Sayoni Das, a computational biologist who leads the research and development of bioinformatics pipelines that generate biological insights from PrecisionLife’s core technology and support drug discovery programs, details…[...]

The Circadian Clock, the Brain, and COVID-19: The Cases of Olfaction and the Timing of Sleep


Rachel S. Herz, , Erik D. Herzog,, Martha Merrow, et. al., Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA, † Abstract Daily…[...]

Multidimensional Sleep Health Prior to SARS-CoV-2 Infection and Risk of Post–COVID-19 Condition


Siwen Wang, MD1; Tianyi Huang, ScD2; Marc G. Weisskopf, PhD, ScD3; et al. JAMA Netw Open. 2023;6(5):e2315885. doi:10.1001/jamanetworkopen.2023.15885 Key Points Question  Is healthy sleep, both before and during the COVID-19 pandemic, prior to SARS-CoV-2 infection, protective against post–COVID-19 condition (PCC)? Findings  In…[...]

Association Between Severities of Obstructive Sleep Apnea and COVID-19 Outcomes


Lamis Alqahtani • Suzana Kano • Hanaa Bokhary •et. al. , DOI: 10.7759/cureus.77626  Abstract Introduction Obstructive sleep apnea (OSA) is characterized by repetitive upper airway collapse resulting in episodes of apnea and hypopnea. Studies have shown…[...]

Viral Persistence and Serotonin Reduction Can Cause Long COVID Symptoms, Penn Medicine Research Finds


Components of the SARS-CoV-2 virus remain in the gut of some long COVID patients, causing persistent inflammation, vagus nerve dysfunction, and neurological symptoms PHILADELPHIA—Patients with long COVID – the long-term symptoms like…[...]

Two-Year Longitudinal Study Reveals That Long COVID Symptoms Peak and Quality of Life Nadirs at 6–12 Months Postinfection 


Zoe O Demko, Tong Yu, Sarika K Mullapudi, M Gabriela Varela Heslin, et. al.Open Forum Infectious Diseases, Volume 11, Issue 3, March 2024, ofae027, https://doi.org/10.1093/ofid/ofae027 Abstract Background Few longitudinal studies available characterize long COVID outcomes…[...]

NIH to open long COVID clinical trials to study sleep disturbances, exercise intolerance, and post exertional malaise


Part of the NIH RECOVER Initiative, trials will test four treatments. The National Institutes of Health (NIH) will launch clinical trials to investigate potential treatments for long-term symptoms after COVID-19…[...]

Pfizer/BioNTech SARS-CoV-2 vaccine as a potential trigger for the development of narcolepsy: a case report


Ala Mahamid 1, Robyn Jacob Bornstein 2, Hagay Amir 3 PMID: 35733336 PMCID: PMC9516586 DOI: 10.5664/jcsm.10134 J Clin Sleep Med. 2022 Oct 1;18(10):2503-2506. doi: 10.5664/jcsm.10134. Abstract Narcolepsy is a rare condition in Israel. Currently, the incidence of narcolepsy following SARS-CoV-2…[...]