Long COVID and Restless Legs Syndrome: Neuroimmune Mechanisms, Iron Homeostasis, Genomic Susceptibility, Diagnostic Evaluation, and Therapeutic Management

Circadian Rhythm / COVID-19 / Dopamine / Long-haul Disease / Neuroimmune / Restless Legs Syndrome / Sleep & Dreams Posted on: October 18, 2026October 18, 2026

Long COVID and Restless Legs Syndrome: Neuroimmune Mechanisms, Iron Homeostasis, Genomic Susceptibility, Diagnostic Evaluation, and Therapeutic Management

John Murphy, CEO The COVID-19 Long haul Foundation Abstract Background: Long COVID is a heterogeneous post-infectious condition associated with persistent neurological, autonomic, cognitive, and sleep-related symptoms. Restless legs syndrome (RLS), […]

Brain Fog / Sleep & Dreams / Sleep Deprivation / Sleep Disturbance / Sleep Latency / Sleep-Wake Disorders Posted on: October 13, 2026September 5, 2026

The COVID Sleep Crisis

For millions of people, COVID didn’t just steal their energy. It changed the way they sleep. By John Murphy, CEO The COVID Long haul Foundation At 3 a.m., the house […]

Dysautonomia / Postural Orthostatic Tachycardia (POTS) / Sleep & Dreams / Sleep Deprivation / Sleep Disturbance / Sleep Latency / Sleep-Wake Disorders Posted on: October 12, 2026September 3, 2026

When the Lights Go Out: Long COVID, Transient Loss of Consciousness, Sleep Disturbance, and the Unfinished Science of Cerebral Autonomic Dysfunction

John Murphy, CEO The COVID-19 Long haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), has increasingly been recognized as a multisystem disorder in which neurological, cardiovascular, […]

Actigraphy / Circadian Rhythm / Depression & Mental Health / Endocrine contributors / Idiopathic Hypersomnia / Narcolepsy / Parasomnias / Polysomnography / Psychiatric Disorders / Restless Legs Syndrome / Sleep & Dreams / Sleep Disturbance / Sleep Latency / Sleep-Wake Disorders Posted on: July 24, 2026July 8, 2026

Sleep Disorders: Etiology, Physiology, Pathology, Clinical Presentation, Diagnostics, Differential Diagnosis, Treatment, and Long-Term Outcomes

A Comprehensive Clinical and Neurobiological Review john Murphy, CEO, The COVID-19 Long-haul Foundation Abstract Sleep disorders comprise a heterogeneous group of conditions characterized by disruption of sleep quantity, quality, timing, […]

Anxiety / Circadian Rhythm / Cognitive deficit / Depression & Mental Health / Fatigue / Inflammation / Mitochondria / Neurologic Effects / PASC / Sleep & Dreams / Sleep Deprivation / Sleep Disturbance Posted on: July 11, 2026June 23, 2026

Long COVID and Sleep Disorders: An Emerging Biologic Nexus in Post-Acute Sequelae of SARS-CoV-2 Infection

John Murphy, CEO, COVID-19 Long-haul Foundation Abstract Sleep disturbance has emerged as one of the most prevalent, persistent, and disabling manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), commonly known […]

Insomnia / Sleep & Dreams Posted on: March 20, 2026March 3, 2026

“Sleepless After the Storm: Neuroimmune Mechanisms and Therapeutic Frontiers in COVID-Related Insomnia”

John Murphy, CEO The COVID-Long Haul Foundation Introduction The COVID-19 pandemic has reshaped the landscape of global health, not only through its acute respiratory manifestations but also via its insidious […]

Sleep & Dreams / Sleep Deprivation / Sleep Disturbance Posted on: January 21, 2026November 20, 2025

Post-Acute Sequelae of SARS-CoV-2 Infection: Sleep Disturbances in Long COVID

John Murphy, CEO, The COVID-19 Long-haul Foundation Abstract Sleep disturbances have emerged as one of the most persistent and debilitating manifestations of Post-Acute Sequelae of SARS-CoV-2 infection (PASC), commonly referred […]

ME/CFS / Narcolepsy Posted on: November 5, 2025October 18, 2025

Neuroimmune Convergence in Narcolepsy and Long COVID-Associated ME/CFS

John Murphy, The COVID Long-haul Foundation Introduction Narcolepsy and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), particularly as it manifests in the context of Long COVID, represent two distinct clinical entities with […]

Melatonin / Sleep & Dreams / Sleep Disturbance / Treatments Posted on: October 25, 2025October 13, 2025

Title: Melatonin as a Therapeutic Agent in Long COVID Sleep Disorders: A Multidimensional Review

John Murphy, The Covid-19 Long haul Foundation Abstract Sleep disturbances have emerged as one of the most persistent and debilitating symptoms of Long COVID, affecting up to 76% of patients […]

Apnea / Insomnia / Narcolepsy / PASC / Sleep & Dreams / Sleep Disturbance Posted on: September 26, 2025June 17, 2025

Severe persistent specific sleep disorders in post-acute sequelae of SARS-CoV-2 Free

Richard Czuma , Robert Thomas , Jason Maley , Danielle Gott, Sleep, Volume 46, Issue Supplement_1,, https://doi.org/10.1093/sleep/zsad077.0969 Abstract Introduction Viral infections have long been associated with sleep disorders, especially hypersomnia following the acute phase The Covid-19 epidemic […]