The coagulopathy, endotheliopathy, and vasculitis of COVID-19

Authors: Toshiaki Iba 1, Jean Marie Connors 2, Jerrold H Levy 3 PMID: 32918567 PMCID: PMC7486586 DOI: 10.1007/s00011-020-01401-6 Abstract Background COVID-19-associated coagulopathy (CAC) characterized by the elevated D-dimer without remarkable changes of other global coagulation markers is associated…[...]

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Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition

Authors: Jia Yu, Xuan Yuan, Hang Chen, Shruti Chaturvedi, Evan M. Braunstein, Robert A. Brodsky Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious respiratory virus that can lead to venous/arterial thrombosis, stroke,…[...]

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