Category: Immune System

SARS-CoV-2 infection modifies the transcriptome of the megakaryocytes in the bone marrow

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Isabelle Allaeys, Guillaume Lemaire, Mickaël Leclercq, et. al. Blood Adv (2024) 8 (11): 2777–2789. Megakaryocytes (MKs), integral to platelet production, predominantly reside in the bone marrow (BM) and undergo regulated fragmentation within sinusoid vessels to release platelets into the bloodstream. Inflammatory states and infections influence MK transcription, potentially affecting platelet functionality. Notably, COVID-19 has been associated […]

The blood holds clues to understanding long COVID

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The search for biomarkers could eventually lead scientists to tests and treatments By Meghan Rosen, MARCH 4, 2024 Science News When I talk to immunologist Paul Morgan, he’s on the hunt for potentially life-altering drugs.  He’s got a call with a pharmaceutical company planned in the next half hour. His goal: persuade the company to supply his lab […]

The Neurological Implications of COVID-19: A Comprehensive Narrative Review

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Ithamar Cheyne • Venmanassery Sreejan Gopinath • Neeharika Muppa , et. al., May 15, 2024, DOI: 10.7759/ cureus.60376  Abstract The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 revealed a huge number of problems as well as discoveries in medicine, notably, regarding the effects of the virus on the central nervous system (CNS) and peripheral nervous system (PNS). This paper is a narrative […]

New study reveals insights into COVID-19 antibody response durability

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University of Maryland School of Medicine, 2024 Researchers at the Institute of Human Virology (IHV) at the University of Maryland School of Medicine have published a new study in the Journal of Infectious Diseases investigating the antibody response following SARS-CoV-2 infection. Long-lived plasma cells are responsible for durable antibody responses that persist for decades after immunization or infection. For example, infection […]

People with long COVID have distinct patterns of inflammation detectable in the blood, which could potentially be targeted with immune therapies.

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Findings from the largest UK study of patients hospitalized with SARS-CoV-2 infection show that long COVID leads to ongoing inflammation which can be detected in the blood. In an analysis of more than 650 people who had been hospitalized with severe COVID-19, patients with prolonged symptoms showed evidence of immune system activation. The exact pattern […]

COVID and Leukemia: What’s the Connection?

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Written by Lisa Mulcahy, May 31, 2023 – WebMD Once you test negative after a bout with COVID-19, it’s a great idea to get a full health screening. This is especially important for people who are at risk for, or have, blood cancers like leukemia.  If you have blood cancer, you need to have a clear picture […]

People with Long COVID Have Distinct Hormonal and Immune Differences From Those Without This Condition

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Research conducted at Mount Sinai and Yale confirms long COVID is a biological disease by showing blood biomarkers that can predict who has it (September 25, 2023) Nature Long COVID patients have clear differences in immune and hormone function from patients without the condition, according to a new study led by the Icahn School of […]

Are we treating long COVID wrong? Immune-boosting treatment takes new approach

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Coronavirus data All data and statistics are based on publicly available data at the time of publication. Some information may be out of date. Visit our coronavirus hub for the most recent information on COVID-19. Was this helpful? A monoclonal antibody treatment called leronlimab could reduce long COVID symptoms in some patients, according to a recent pilot study published in the […]

Complement system causes cell damage in long Covid

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Date: January 18, 2024 Source:University of Zurich Summary: Long Covid patients suffer from chronic symptoms such as fatigue or shortness of breath. As researchers have discovered, this is to some extent due to a part of our immune system called the complement system. The study identified a pattern in the blood proteins that will improve […]

Understanding long COVID: A call for better diagnosis and treatment

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By Vijay Kumar Malesu,Mar 7 2024 In a recent review published in the journal Nature Reviews Microbiology, a group of authors summarized recent advancements in understanding long coronavirus disease (COVID) ‘s mechanisms, impacts, and research needs for better diagnostics and treatments. Review: Long COVID: major findings, mechanisms and recommendations Background Long COVID, affecting over 65 million globally, manifests through […]