Treating COVID in a Shifting Landscape

SARS-CoV-2 keeps changing. What does this mean for the treatment of COVID-19? By EKATERINA PESHEVA January 3, 2023 Research Harvard As the world enters year four of the COVID-19 pandemic, scientists have amassed a great deal of knowledge about the biology and behavior of SARS-CoV-2 and about the clinical features of the disease that it causes. They […]

A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes

Theo Sanderson, Ryan Hisner, I’ah Donovan-Banfield, Hassan Hartman, Alessandra Løchen, Thomas P. Peacock & Christopher Ruis Nature (2023) Cite this article Abstract Molnupiravir, an antiviral medication widely used against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), acts by inducing mutations in the virus genome during replication. Most random mutations are likely to be deleterious to the virus and many will be lethal; thus, molnupiravir-induced […]

COVID-19 Therapeutics for Nonhospitalized Patients

Rajesh T. Gandhi, MD1; Preeti N. Malani, MD, MSJ2,3; Carlos del Rio, MD4, JAMA. 2022;327(7):617-618. doi:10.1001/jama.2022.0335 Substantial progress has been made in therapeutics for nonhospitalized patients with COVID-19, but supply of and access to treatment remain limited. This Viewpoint summarizes currently available therapeutics for nonhospitalized patients in the setting of the Omicron variant including principles for equitable allocation. Patients with mild or moderate COVID-19 […]