John Murphy, CEO The COVID-19 Log haul Foundation Abstract Importance: Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), is a heterogeneous multisystem disorder that may persist for months or […]
Long COVID and the Reactivation of Latent Viruses
John Murphy, CEO, The COVID-19 Long-haul Foundation A mechanistic synthesis of Epstein–Barr virus, persistent SARS-CoV-2, immune dysregulation, and host susceptibility Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), […]
Long COVID as a Multisystem Postviral Disorder
John Murphy, CEO, The COVID-19 Long haul Foundation A mechanistic synthesis of persistent SARS-CoV-2 infection, immune dysregulation, autoimmunity, vascular dysfunction, metabolic disturbance, and host susceptibility Summary Post-acute sequelae of SARS-CoV-2 […]
Long COVID and Renal Disease: Pathophysiology, Genomics, Clinical Manifestations, and Long-Term Implications
Abstract Long coronavirus disease (Long COVID, post-acute sequelae of SARS-CoV-2 infection [PASC]) has emerged as a major chronic health challenge affecting multiple organ systems. Although pulmonary, cardiovascular, and neurologic manifestations […]
Long COVID, Chronic Urticarial Pruritus
Background John Murphy, CEO COV-19 Long-haul Foundation Persistent dermatologic manifestations represent an increasingly recognized component of post-acute sequelae of SARS-CoV-2 infection (PASC), commonly termed Long COVID. Among these manifestations, chronic […]
NIH RECOVER Clinical Trials and the First Emergence of Interventional Results in Long COVID Research: A Translational Turning Point
A Scholarly Review for Scientific American (Submission-Style Manuscript) John Murphy, M.D., M.P.H., D.P.H., President, COVID-19 Long-Haul Foundation Abstract The NIH RECOVER Initiative represents the largest coordinated research program investigating post–acute […]
COVID-19 infection induces long-term changes in the immune system
John Murphy, CEO COVID-19 Long-haul foundation I. Introduction: The Immune System Under Siege The immune system is a dynamic, multilayered defense network composed of innate and adaptive components, designed to […]
🧠 Neurovascular Dysregulation and Microclot Persistence in COVID-19 Long-Haul Illnesses
Author: John Murphy, President, COVID-19 Long-haul Foundation 📑 Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), affects millions globally and presents with persistent symptoms including fatigue, cognitive dysfunction, […]
COVID-19 and immune dysregulation: Genomic pathways, clinical manifestations, and therapeutic strategies
John Murphy, CEO & President, COVID-19 Long-haul Foundation Abstract SARS-CoV-2 provokes a uniquely heterogeneous and dynamic immune response that ranges from efficient viral control to fulminant hyperinflammation and prolonged immune […]
The Lingering Pandemic: Mapping the Arc of Long COVID and the Search for Recovery
By John Murphy, The COVID 19 Long-haul Foundation Introduction: A Pandemic That Didn’t End When the world first confronted SARS-CoV-2 in early 2020, the prevailing narrative was one of acute […]