Category: Biomarkers

SARS-CoV-2 particles promote airway epithelial differentiation and ciliation

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Julian Gonzalez-Rubio1 Vu Thuy Khanh Le-Trilling2 Lea Baumann1 Maria Cheremkhina1 Hannah Kubiza1 Anja E. Luengen1,3 Sebastian Reuter3 Christian Taube3 Stephan Ruetten4 Daniela Duarte Campos5 Christian G. Cornelissen1,6 Mirko Trilling2 Anja Lena Thiebes1, Front. Bioeng. Biotechnol., 02 November 2023 Sec. Tissue Engineering and Regenerative MedicineVolume 11 – 2023 | https://doi.org/10.3389/fbioe.2023.1268782 Introduction: The Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which caused the coronavirus disease 2019 (COVID-19) pandemic, enters the […]

Neurological manifestations of post-acute sequelae of COVID-19: which liquid biomarker should we use?

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Dominique Comeau1† Mykella Martin2† Gilles A. Robichaud3,4,5 Ludivine Chamard-Witkowski2,6*1Dr. Georges-L. Long COVID syndrome, also known as post-acute sequelae of COVID-19 (PASC), is characterized by persistent symptoms lasting 3–12 weeks post SARS-CoV-2 infection. Patients suffering from PASC can display a myriad of symptoms that greatly diminish quality of life, the most frequent being neuropsychiatric. Thus, there is an eminent need […]

Blood Biomarkers Highlight Immune Disruption in Long-COVID

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Featured Neurology Neuroscience, September 25, 2023 Summary: Researchers reveal distinctive blood biomarkers in long COVID patients. This groundbreaking study establishes clear differences in immune and hormone function between individuals with long COVID and those without. Key biomarkers include abnormal T cell activity, reactivation of latent viruses, and reduced cortisol levels. The findings pave the way for […]

UK scientists find link between proteins related to blood clots and long Covid

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Biomarker discovery indicates that sufferers from brain fog and fatigue post-virus could be treated with anticoagulants Oksana Pyzik 31 Aug 2023 The Guardian Scientists have identified molecular signatures in the blood that are linked to brain fog, other cognitive problems and fatigue in patients who are diagnosed with long Covid after catching the virus. Raised levels of […]

Vaccine-induced immune thrombotic thrombocytopenia

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BLOOD SPOTLIGHT| APRIL 6, 2023 Douglas B. Cines, Andreas Greinacher Blood (2023) 141 (14): 1659–1665. https://doi.org/10.1182/blood.2022017696 Within the first months of the COVID-19 vaccination campaign, previously healthy recipients who developed severe thrombosis (often cerebral and/or splanchnic vasculature) and thrombocytopenia typically after adenoviral vector-based vaccination were identified. Similarities between this syndrome, vaccine-induced immune thrombotic thrombocytopenia (VITT), and heparin-induced […]

Large COVID autopsy study finds SARS-CoV-2 all over the human body

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By Rich Haridy January 04, 2023 Source: National Institute of Allergy and Infectious Diseases A study found traces of the SARS-CoV-2 virus in over 80 different sites in the body In the most comprehensive autopsy tissue study conducted to date, researchers have found traces of the SARS-CoV-2 virus throughout the entire body, from the brain and the […]

Post-COVID Interstitial Lung Disease—The Tip of the Iceberg

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Namrata Kewalramani, MD,a,b,∗ Kerri-Marie Heenan, MB Bch, BAO,c Denise McKeegan, MB Bch, BAO, MSc,c and Nazia Chaudhuri, MD, PhDd Immunol Allergy Clin North Am. 2023 May; 43(2): 389–410. Published online 2023 Mar3. doi: 10.1016/j.iac.2023.01.004 PMCID: PMC9982726PMID: 37055095 The proportion of symptomatic patients with post-coronavirus 2019 (COVID-19) condition (long COVID) represents a significant burden on the individual as well as on the health care systems. […]

Biomarkers in long COVID-19: A systematic review

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Front. Med., 20 January 2023 Sec. Infectious Diseases: Pathogenesis and TherapyVolume 10 – 2023 | https://doi.org/10.3389/fmed.2023.1085988 Yun-Ju Lai1*† Shou-Hou Liu2† Sumatchara Manachevakul1† Te-An Lee2,3 Chun-Tse Kuo2 Dhimiter Bello4  Purpose: Long COVID, also known as post-acute sequelae of COVID-19, refers to the constellation of long-term symptoms experienced by people suffering persistent symptoms for one or more months after SARS-CoV-2 infection. Blood biomarkers can […]

Biomarkers: Promising and valuable tools towards diagnosis, prognosis and treatment of Covid-19 and other diseases

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Ali Bodaghi,a Nadia Fattahi,b,c and Ali Ramazanib,d,∗ Heliyon. 2023 Feb; 9(2): e13323. Published online 2023 Jan 30. doi: 10.1016/j.heliyon.2023.e13323 PMCID: PMC9884646 PMID: 36744065 The use of biomarkers as early warning systems in the evaluation of disease risk has increased markedly in the last decade. Biomarkers are indicators of typical biological processes, pathogenic processes, or pharmacological reactions to therapy. The application and identification of biomarkers […]

Auditory Disturbances and SARS-CoV-2 Infection: Brain Inflammation or Cochlear Affection? Systematic Review and Discussion of Potential Pathogenesis

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Pietro De Luca1, Alfonso Scarpa1, Massimo Ralli2, Domenico Tassone3, Matteo Simone3, Luca De Campora3, Claudia Cassandro4† and Arianna Di Stadio Frontiers in Medicine Patients affected by COVID-19 present a series of different symptoms; despite some of these are common, other less likely appear. Auditory symptoms seem to be less frequent, maybe because rarer or, alternatively, because they are underestimated during the clinical investigation. […]