Category: CNS

Alteration of the blood-brain barrier by COVID-19 and its implication in the permeation of drugs into the brain

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Héctor Hernández-Parra1,2 Octavio Daniel Reyes-Hernández3 Gabriela Figueroa-González4 Manuel González-Del Carmen5 Maykel González-Torres6 Sheila I. Peña-Corona2 Benjamín Florán7 Hernán Cortés8* Gerardo Leyva-Gómez2* https://pubmed.ncbi.nlm.nih.gov/36998270/ Diverse neurological symptoms have been reported in patients with SARS-CoV-2 disease (COVID-19), including stroke, ataxia, meningitis, encephalitis, and cognitive impairment. These alterations can cause serious sequelae or death and are associated with the entry of SARS-CoV-2 into the Central Nervous System […]

COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside

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David Sulzer, Angelo Antonini, Valentina Leta, Anna Nordvig, Richard J. Smeyne, James E. Goldman, Osama Al-Dalahmah, Luigi Zecca, Alessandro Sette, Luigi Bubacco, Olimpia Meucci, Elena Moro, Ashley S. Harms, Yaqian Xu, Stanley Fahn & K. Ray Chaudhuri  npj Parkinson’s Disease volume 6, Article number: 18 (2020) Cite this article Abstract This Viewpoint discusses insights from basic science and clinical perspectives on coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection in the brain, with a particular focus […]

Coronavirus and the Nervous System

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What is SARS-CoV-2 and COVID-19? National Institute of Neurological Disorders and Stroke Coronaviruses are common causes of usually mild to moderate upper respiratory tract illnesses like the common cold, with symptoms that may include runny nose, fever, sore throat, cough, or a general feeling of being ill. However, a new coronavirus called Severe Acute Respiratory […]

Hypoglossal Nerve Palsy Following COVID-19 Vaccination in a Young Adult Complicated by Various Medicines

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Authors: Tatsuhiko Okayasu, Ryuichi Ohta, Fumiko Yamane, Satoshi Abe, Chiaki Sano  September 15, 2022 (see history) DOI: 10.7759/cureus.29212 Cite this article as: Okayasu T, Ohta R, Yamane F, et al. (September 15, 2022) Hypoglossal Nerve Palsy Following COVID-19 Vaccination in a Young Adult Complicated by Various Medicines. Cureus 14(9): e29212. doi:10.7759/cureus.29212 Abstract Mononeuritis multiplex is a rare form of cerebral nerve palsy […]

COVID-19: A Global Threat to the Nervous System

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Authors: Igor J. Koralnik MD,Kenneth L. Tyler MD 07 June 2020 Annals of NeurologyVolume 88, Issue 1 p. 1-11 Abstract In less than 6 months, the severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) has spread worldwide infecting nearly 6 million people and killing over 350,000. Initially thought to be restricted to the respiratory system, we now […]

Alzheimer’s-like signaling in brains of COVID-19 patients

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Authors: Steve Reiken,Leah Sittenfeld,Haikel Dridi,Yang Liu,Xiaoping Liu,Andrew R. Marks First published: 03 February 2022  https://doi.org/10.1002/alz.12558 Abstract Introduction The mechanisms that lead to cognitive impairment associated with COVID-19 are not well understood. Methods Brain lysates from control and COVID-19 patients were analyzed for oxidative stress and inflammatory signaling pathway markers, and measurements of Alzheimer’s disease (AD)-linked […]

A Case Of Shrunken Brains: How Covid-19 May Damage Brain Cells

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Authors: William A. Haseltine Forbes March 22, 2022 Thanks to a new study from the UK we are now beginning to uncover the effects of SARS-CoV-2 infections in the brain. Comparing brain volume before and after individuals were exposed to SARS-CoV-2, this study documents significant cortical gray matter loss, equivalent to nearly 10 years of aging. Gweanaelle […]

Acute inflammatory demyelinating polyneuropathy or Guillain-Barré syndrome associated with COVID-19: a case report

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Authors: Dmitriy A. Gagarkin, Keith E. Dombrowski, Keyur B. Thakar & John C. DePetrillo  Journal of Medical Case Reports volume 15, Article number: 219 (2021)  Abstract Background Coronavirus disease 2019 (COVID-19) is a global pandemic. The disease, typically characterized by bilateral pulmonary infiltrates and profound elevation of inflammatory markers, can range in severity from mild or asymptomatic illness to a lethal cytokine storm and […]

COVID-19 and emerging spinal cord complications: A systematic review

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Authors: Ritwick Mondal,aShramana Deb,bGourav Shome,cUpasana Ganguly,aDurjoy Lahiri,a,d,⁎ and Julián Benito-Leóne,f,g,⁎⁎ Mult Scler Relat Disord. 2021 Jun; 51: 102917.Published online 2021 Mar 21. doi: 10.1016/j.msard.2021.102917 Abstract Background Spinal cord complications associated with coronavirus infectious disease of 2019 (COVID-19) are being widely reported. The purpose of this systematic review was to summarize so far available pieces of evidence documenting de novo novel severe acute […]

Coronavirus and the Nervous System

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What is SARS-CoV-2 and COVID-19? What do we know about the effects of SARS-CoV-2 and COVID-19 on the nervous system? What are the immediate (acute) effects of SARS-CoV-2/COVID-19 on the brain? What is the typical recovery from COVID-19? What are possible long-term neurological complications of COVID-19? How do the long-term effects of SARS-CoV-2 infection/COVID-19 relate […]