Toward a Multisystem Endotype Framework for Post–Acute SARS-CoV-2 Disease John Murphy, M.D., M.P.H., D.P.H. President Covid-19 Long-haul Foundation Abstract Long COVID (post–acute sequelae of SARS-CoV-2 infection, PASC) has emerged as […]
Treatment Landscape in Long COVID Has Expanded Beyond “Supportive Care”
A Mechanism-Driven Reframing of Therapeutic Development in Post–Acute SARS-CoV-2 Disease John Murphy, M.D, M.P.H., D.P.H. President COVID Long-haul Foundation Conceptual Shift and Therapeutic Reclassification ABSTRACT For much of the early […]
Persistent Viral Reservoirs and Immune Dysregulation in Long COVID
John Murphy, M.D., M.P.H., D.P.H., President Covid-19 Long-haul Foundation The Central Discovery Reshaping Post-Acute Sequelae Research Abstract Long COVID (post-acute sequelae of SARS-CoV-2 infection, PASC) has emerged as a multisystem […]
Persistent Immune Exhaustion in Post–Acute Sequelae of SARS-CoV-2 Infection
John Murphy, M.D., M.P.H., D.P.H. President Cov-19 Long-haul Foundation Immunologic Foundations, T-cell Dysfunction, and Exhaustion Signatures Abstract Importance: Post–acute sequelae of SARS-CoV-2 infection (PASC), commonly referred to as Long COVID, […]
COVID-19–Associated Neuropathy of the Feet and Legs: Etiology, Pathophysiology, Clinical Course, and Therapeutic Approaches
Abstract Peripheral neuropathy involving the feet and legs has emerged as one of the most prevalent and disabling neurological sequelae associated with acute and post-acute COVID-19 illness. Although initially overshadowed […]
Severe cerebral amyloid angiopathy related inflammation (CAA-ri) associated with vaccination
Michael Tang 1, Jane Kim 2, Kui Kai Lau 3, Koon Ho Chan 3, PMID: 39094435, DOI: 10.1016/j.jneuroim.2024.578406 Abstract Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rapid but reversible autoimmune encephalopathy where spontaneous autoantibody reaction against amyloid beta deposited […]
Virologist accused of starting COVID-19 will fight U.S. ban on funding
HHS memo says Ralph Baric had a “pattern of deception” in describing virus studies long before pandemic By Jon Cohen Alleging a “pattern of deception” in virus studies done more […]
Amyloid β-related angiitis of the central nervous system occurring after COVID-19 vaccination: A case report
Mayuri Kizawa 1, Yasushi Iwasaki, PMCID: PMC9791501 PMID: 36579089 Abstract BACKGROUND Although coronavirus disease 2019 (COVID-19) vaccines have been effective in controlling the COVID-19 pandemic, a variety of post-vaccination neurological complications have been reported worldwide. […]
COVID-19–Associated Gustatory Dysfunction: Pathophysiology, Clinical Trajectory, and Therapeutic Strategies
A Comprehensive Clinical and Mechanistic Review Author: John Murphy, M.D., M.P.H., D.P.H.Affiliation: COVID-19 Long-haul Foundation Abstract Background: Alterations in taste perception (dysgeusia and ageusia) emerged as a hallmark symptom of […]
US FDA blocked publication of COVID, shingles vaccine safety studies
By Padmanabhan Ananthan May 5 (Reuters) – Officials at the U.S. Food and Drug Administration blocked the publication of several studies supporting the safety of widely used vaccines against COVID-19 and […]