SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation


Authors: Luca Perico 1, Marina Morigi 1, et. al.; 2022 Mar 7;13:827146. doi: 10.3389/fimmu. 2022.827146. eCollection 2022. Abstract Microvascular thrombosis is associated with multiorgan failure and mortality in coronavirus disease 2019 (COVID-19). Although thrombotic complications may…[...]

Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis


James May, Jane A. Mitchell, and R. Gisli Jenkins, Published September 15, 2023 - 10.1172/JCI172058 Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor survival. The incidence and…[...]

Treatment of Long COVID symptoms with triple anticoagulant therapy


Gert J Laubscher, M Asad Khan, Chantelle Venter, Jan H Pretorius, and 2 more, This is a preprint; it has not been peer reviewed by a journal. https://doi.org/10.21203/rs.3.rs-2697680/v1 Research Square…[...]

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies


Suo-wen Xu, Iqra Ilyas & Jian-ping Weng  Acta Pharmacologica Sinica volume 44, pages695–709 (2023) Cite this article 17 October 2022 Abstract The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However,…[...]

Long COVID scientists try to unravel blood clot mystery


May 15, 202312:15 AM ET By Anil Oza, Rebecca Ramirez, Emily Kwong, Gabriel Spitzer, Margaret Cirino, Berly McCoy, https://www.npr.org/2023/05/10/1175217130/long-covid-scientists-try-to-unravel-blood-clot-mystery As part of studying long COVID, graduate researcher Bradley Wade Hamilton separates out microclots from blood platelets…[...]

An overview of human proteins and genes involved in SARS-CoV-2 infection


Zohreh Jahanafrooz,a,⁎ Zhishan Chen,b Jiandong Bao,c Hongzhi Li,d Loren Lipworth,b and Xingyi Guob,e,⁎Gene. 2022 Jan 15; 808: 145963. Published online 2021 Sep 14. doi: 10.1016/j.gene.2021.145963 PMCID: PMC8437745PMID: 34530086 Graphical abstract A summarized view of recent findings of host proteins interacting with…[...]

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies


Suo-wen Xu, Iqra Ilyas & Jian-ping Weng Acta Pharmacologica Sinica volume 44, pages695–709 (2023) Nature Abstract The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However, the pathophysiology of acute and post-acute…[...]

Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein


Gerard J Nuovo 1, Cynthia Magro 2, Toni Shaffer 3, Hamdy Awad 4, David Suster 5, Sheridan Mikhail 3, Bing He 2, Jean-Jacques Michaille 6, Benjamin Liechty 2, Esmerina Tili 4 PMID: 33360731 PMCID: PMC7758180DOI: 10.1016/j.anndiagpath.2020.151682 Abstract Neurologic complications of symptomatic COVID-19 are common. Brain tissues from 13 autopsies of people who…[...]