John Murphy, President The COVID Long-haul Foundation Abstract The SARS-CoV-2 spike (S) protein is the principal mediator of viral entry and a key determinant of COVID-19 pathogenesis. This article provides […]
Long Covid: Hormone Imbalances and/or Rather Complex Immune Dysregulations?
Christian A Koch, Journal of the Endocrine Society, Volume 8, Issue 5, May 2024, bvae043, https://doi.org/10.1210/jendso/bvae043 Commentary Approximately 5% of all individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) […]
Endothelial Disruption in Long COVID: Unraveling the Vascular Legacy of SARS-CoV-2
John Murphy, The COVID 19 Long-haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), has emerged as a chronic multisystem disorder affecting millions worldwide. Among its most […]
Long covid patients are desperate for treatments. These trials may help.
By Richard Sima The Washington Post Five years since the pandemic began, millions of people are still grappling with long COVID, even as new patients are joining their ranks. “Considering […]
❄️ COVID-19 and Chilblains: Unraveling the Dermatologic Puzzle in 2025
🔬 Overview As the COVID-19 pandemic enters its fifth year, dermatological manifestations remain a key area of clinical and immunological inquiry. Among these, chilblains—also known as pernio—have emerged as a […]
🩸 COVID-19 and Chronic Venous Insufficiency: 2025 Research Insights on Etiology, Vascular Damage, and Treatment
Chronic Venous Insufficiency (CVI)—a condition where leg veins fail to return blood efficiently to the heart—has gained renewed attention in 2025 due to its association with COVID-19, particularly in patients […]
Intranasal Chlorpheniramine for Early Symptomatic Treatment of COVID-19 and the Impact on Long-COVID
Gustavo Ferrer • Fernando Valerio-Pascua • César Alas-Pineda • et.al., DOI: 10.7759/cureus.82736 Abstract This review explores the therapeutic potential of intranasal chlorpheniramine maleate (iCPM) in managing both acute COVID-19 and Long COVID by integrating histamine H1 receptor […]
CD56+ Monocytes and CD31+ Endothelial Cells Are Increased in Severe COVID-19 Disease
Abstract Immune response dysregulation plays a key role in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis. In this study, we evaluated immune and endothelial blood cell profiles of patients […]
A Systematic Review of Case Reports of New-Onset Atrial Fibrillation in COVID-19 Patients
Rocio Barriga Guzman • Oluwaremilekun Tolu-Akinnawo • Toluwalase Awoyemi • et. al DOI: 10.7759/cureus.78938 Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic posed a significant global public health challenge, affecting millions of individuals. While some […]
How COVID-19 Affects the Brain
Maura Boldrini, MD, PhD1,2; Peter D. Canoll, MD, PhD3; Robyn S. Klein, MD, PhD4,5,6, JAMA Psychiatry. 2021;78(6):682-683. doi:10.1001/jamapsychiatry.2021.0500 COVID-19 has resulted in more than 120 million cases and 2.6 million deaths to date. Respiratory and gastrointestinal symptoms are accompanied […]