Endothelial cell damage is the central part of COVID-19 and a mouse modelinduced by injection of the S1 subunit of the spike protein

Animal Models / Cytokine Storm / Endothelium / Lung / Neurologic Effects / Neuropathy / Spike Protein Posted on: November 1, 2024July 9, 2024

Endothelial cell damage is the central part of COVID-19 and a mouse model
induced by injection of the S1 subunit of the spike protein

Authors: Gerard J. NuovoCynthia MagroToni ShafferHamdy AwadDavid SusterSheridan MikhailBing HeJean-Jacques MichailleBenjamin LiechtyEsmerina Tili Annals of Diagnostic Pathology ABS T R A C TNeurologic complications of symptomatic COVID-19 are common. Brain […]

Endothelium / Fibroblast / Immune System / Lung / Lung Disease / Pathophysiology Posted on: October 14, 2024July 6, 2024

Spatial transcriptomics unveils the in situ cellular and molecular hallmarks of the lung in fatal COVID-19

Carlos Garcia-Prieto, Eva Musulen, Veronica Davalos, et. al.doi: https://doi.org/10.1101/2024.07.03.601404 00010010 Abstract Severe Coronavirus disease 2019 (COVID-19) induces heterogeneous and progressive diffuse alveolar damage (DAD) highly disrupting lung tissue architecture and homeostasis, hampering disease management and leading to […]

Endothelium / Leukocyte adhesion Posted on: September 30, 2024July 3, 2024

SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation

Authors: Luca Perico1†, Marina Morigi1†, Miriam Galbusera1, et. al. Frontiers in Immunology March 2922 Microvascular thrombosis is associated with multiorgan failure and mortality in coronavirus disease 2019 (COVID-19). Although thrombotic complications may be ascribed […]

Clots & Bleeds / Complement System / Endothelium / Thromboembolism / Thrombosis Posted on: January 30, 2024January 19, 2024

SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation

Authors: Luca Perico 1, Marina Morigi 1, et. al.; 2022 Mar 7;13:827146. doi: 10.3389/fimmu. 2022.827146. eCollection 2022. Abstract Microvascular thrombosis is associated with multiorgan failure and mortality in coronavirus disease 2019 (COVID-19). Although thrombotic complications may […]

Circulating endothelial cells / Endothelium / Interstitial Fibrosis / Lung / Lung Disease / Pericytes Posted on: November 17, 2023

Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis

James May, Jane A. Mitchell, and R. Gisli Jenkins, Published September 15, 2023 – 10.1172/JCI172058 Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor survival. The incidence and […]

Blood-brain barrier leakage / Brain / Endothelium / Leaky Vaccines / Vaccine Failure / Vaccine Long-term Safety / Vaccine Safety Posted on: October 26, 2023

Brain Injuries After COVID Vaccination

Colleen Huber April 12, 2023 HEALTH VIEWPOINTS, There are back door routes to the brain. COVID vaccine developers have traversed a path through those doors. And they knew they had […]

Anticoagulant / Clots & Bleeds / Cognitive deficit / Endothelium / Fatigue / fibrinogen / Fibrinolysis / Hypertension / Microclotting / Shortness of Breath Posted on: October 20, 2023

Treatment of Long COVID symptoms with triple anticoagulant therapy

Gert J Laubscher, M Asad Khan, Chantelle Venter, Jan H Pretorius, and 2 more, This is a preprint; it has not been peer reviewed by a journal. https://doi.org/10.21203/rs.3.rs-2697680/v1 Research Square […]

Autoimmune Disease / Bone Marrow / Brainstem / Chronic Fatigue Syndrome / Clots & Bleeds / Endothelium / Epstein Barr / Gastrointestinal / Herpes Simplex / Lung / Micro vessels / Myalgic Encephalomyelitis / Sex Related Outcome / Spinal Cord / T-cell / Viral persistence Posted on: October 20, 2023

Unraveling long COVID: Here’s what scientists who study the illness want to find out

September 9, 2023, By Will Stone NPR Newsletter Researchers looking for root causes of long COVID work in the autopsy suite inside the Clinical Center at the National Institute of Health […]

ACE2 Receptors / Apoptosis / Clots & Bleeds / Cytokine Storm / Endothelium / Kidney / Liver / Lung / Mitochondria / Myocardial Infarct / Spike Protein / Treatments / Uncategorized Posted on: October 18, 2023

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

Suo-wen Xu, Iqra Ilyas & Jian-ping Weng Acta Pharmacologica Sinica volume 44, pages695–709 (2023) Cite this article 17 October 2022 Abstract The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However, […]

Arthritis / Biomarker / Clots & Bleeds / Diabetes / Endothelium / Inflammation / Lupus / Microclotting Posted on: October 13, 2023

Long COVID scientists try to unravel blood clot mystery

May 15, 202312:15 AM ET By Anil Oza, Rebecca Ramirez, Emily Kwong, Gabriel Spitzer, Margaret Cirino, Berly McCoy, https://www.npr.org/2023/05/10/1175217130/long-covid-scientists-try-to-unravel-blood-clot-mystery As part of studying long COVID, graduate researcher Bradley Wade Hamilton separates out microclots from blood platelets […]