Category: Pathology

Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19

Posted on | Posted on John Murphy | Leave a Comment on Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19

Authors: Stephanie Seneff1and Greg Nigh21Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge MA, 02139, USA, E-mail: seneff@csail.mit.edu 2Naturopathic Oncology, Immersion Health, Portland, OR 97214, USA ABSTRACT Operation Warp Speed brought to market in the United States two mRNA vaccines, produced by Pfizer and Moderna. Interim data suggested high efficacy for both of these vaccines, which […]

Platelet Gene Expression and Function in COVID-19 Patients

Posted on | Posted on John Murphy | Leave a Comment on Platelet Gene Expression and Function in COVID-19 Patients

Authors: Bhanu Kanth Manne (University of Utah, United States) Frederik Denorme (Molecular Medicine Program, University of Utah, United States), Elizabeth Middleton (University of Utah, United States), Irina Portier (University of Utah, United States) Jesse Rowley (University of Utah, United, States) Chris Stubben (University of Utah, United States) Aaron Petrey (University of Utah, United States) Neal […]

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

Posted on | Posted on John Murphy | Leave a Comment on SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

Authors: Si Zhang 1, Yangyang Liu 2, Xiaofang Wang 2, Li Yang 3, Haishan Li 4, Yuyan Wang 5, Mengduan Liu 2, Xiaoyan Zhao 2, Youhua Xie 5, Yan Yang 6, Shenghui Zhang 7, Zhichao Fan 8, Jianzeng Dong 2, Zhenghong Yuan 5, Zhongren Ding 2, Yi Zhang 9, Liang Hu 10 Abstract Background: Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic state that places them at a dramatically increased lethal risk. Although platelet activation is critical for thrombosis and is responsible for the thrombotic events and […]

The Impact of COVID-19 Disease on Platelets and Coagulation

Posted on | Posted on John Murphy | Leave a Comment on The Impact of COVID-19 Disease on Platelets and Coagulation

Authors: Geoffrey D Wool 1, Jonathan L Miller 2 Abstract Coronavirus disease 2019 (COVID-19) causes a spectrum of disease; some patients develop a severe proinflammatory state which can be associated with a unique coagulopathy and procoagulant endothelial phenotype. Initially, COVID-19 infection produces a prominent elevation of fibrinogen and D-dimer/fibrin(ogen) degradation products. This is associated with systemic hypercoagulability and […]

SARS-CoV-2 mediated neuroinflammation and the impact of COVID-19 in neurological disorders

Posted on | Posted on John Murphy | Leave a Comment on SARS-CoV-2 mediated neuroinflammation and the impact of COVID-19 in neurological disorders

Authors: Narayanappa Amruta,a Wesley H. Chastain,a Meshi Paz,a Rebecca J. Solch,b Isabel C. Murray-Brown,a Jaime B. Befeler,a Timothy E. Gressett,a Michele T. Longo,b,c Elizabeth B. Engler-Chiurazzi,a,c and Gregory Bixa,b,c,* Abstract SARS-CoV-2 is a novel coronavirus that severely affects the respiratory system, is the cause of the COVID-19 pandemic, and is projected to result in the deaths of 2 million people worldwide. Recent reports suggest that […]

Insights into How SARS-CoV-2 Causes Brain Pathology

Posted on | Posted on John Murphy | Leave a Comment on Insights into How SARS-CoV-2 Causes Brain Pathology

Authors: Anthony L. Komaroff, MD, reviewing Yang AC et al. Nature 2021 Jul Marshall M. Nature 2021 Jul In deceased COVID-19 patients, gene expression in the choroid plexus was altered. People infected with SARS-CoV-2 can develop a wide variety of neurological conditions: Endothelial dysfunction can lead to ischemic and hemorrhagic strokes, even in young adults. Demyelinating diseases occur. Autoantibodies that […]

NIH study uncovers blood vessel damage and inflammation in COVID-19 patients’ brains but no infection

Posted on | Posted on John Murphy | Leave a Comment on NIH study uncovers blood vessel damage and inflammation in COVID-19 patients’ brains but no infection

Authors: Christopher G. Thomas, 301-496-5751, nindspressteam@ninds.nih.gov Results from a study of 19 deceased patients suggests brain damage is a byproduct of a patient’s illness. In an in-depth study of how COVID-19 affects a patient’s brain, National Institutes of Health researchers consistently spotted hallmarks of damage caused by thinning and leaky brain blood vessels in tissue samples […]

COVID and the brain: researchers zero in on how damage occurs

Posted on | Posted on John Murphy | Leave a Comment on COVID and the brain: researchers zero in on how damage occurs

Authors: Michael Marshall Growing evidence suggests that the coronavirus causes ‘brain fog’ and other neurological symptoms through multiple mechanisms. How COVID-19 damages the brain is becoming clearer. New evidence suggests that the coronavirus’s assault on the brain could be multipronged: it might attack certain brain cells directly, reduce blood flow to brain tissue or trigger […]

SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells

Posted on | Posted on John Murphy | Leave a Comment on SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells

Authors: Yuichiro J. Suzuki,a,⁎ Sofia I. Nikolaienko,b Vyacheslav A. Dibrova,b Yulia V. Dibrova,b Volodymyr M. Vasylyk,c Mykhailo Y. Novikov,d Nataliia V. Shults,a and Sergiy G. Gychkab Currently, the world is suffering from the pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that uses angiotensin-converting enzyme 2 (ACE2) as a receptor to enter the host cells. So […]