John Murphy, President COVID-19 Long-haul Foundation Abstract Long COVID, also termed post-COVID condition or post-acute sequelae of SARS-CoV-2 infection (PASC), continues to represent one of the most consequential chronic disease […]
Long COVID and Dysautonomia: Emerging Insights Into Autonomic Dysfunction, Vagal Pathobiology, Neuroimmune Interactions, and Therapeutic Strategies
John Murphy, M.D., M.P.H., D.P.H. CEO COVID Long-haul Foundation Abstract Background Long COVID, also termed Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), is a complex multisystem disorder characterized by persistent symptoms […]
Long COVID–Associated Vertigo: Etiology, Pathophysiology, Clinical Course, and Therapeutic Strategies
John Murphy, CEO The COVID-19 Long-haul Foundation Introduction Persistent vertigo and disequilibrium have emerged as prominent neurological sequelae of post-acute SARS-CoV-2 infection, commonly termed long COVID. While early pandemic focus […]
A year of discovery: Looking back at 2025 and ahead to 2026
In 2025, RECOVER used many different study methods to understand who is most impacted by Long COVID and why the condition develops. In 2025, the RECOVER Initiative continued to make […]
Post–Acute Sequelae of Long COVID): Comprehensive Clinical Evaluation, Diagnostic Strategy, and Evidence-Based Management
John Murphy, CEO The COVID-19 Long haul Foundation Abstract Post–acute sequelae of SARS-CoV-2 infection (PASC), widely referred to as Long COVID, has emerged as a complex, heterogeneous, and often debilitating […]
Post-Vaccination Spike Protein Migration: Genomic Mechanisms of Motility, Pathological Spread, and Long-Term Implications
Author: John Murphy, M.D. CEO Covid-19 Long-haul Foundation Abstract Messenger RNA (mRNA) vaccines have revolutionized infectious disease prevention, offering rapid deployment and robust immunogenicity. However, emerging evidence suggests that the […]
Spatial transcriptomics unveils the in situ cellular and molecular hallmarks of the lung in fatal COVID-19
Carlos Garcia-Prieto, Eva Musulen, Veronica Davalos,  et. al.doi: https://doi.org/10.1101/2024.07.03.601404 00010010 Abstract Severe Coronavirus disease 2019 (COVID-19) induces heterogeneous and progressive diffuse alveolar damage (DAD) highly disrupting lung tissue architecture and homeostasis, hampering disease management and leading to […]
Pathological sequelae of long-haul COVID
Saurabh Mehandru & Miriam Merad, Nature Immunology volume 23, pages194–202 ( Abstract The world continues to contend with successive waves of coronavirus disease 2019 (COVID-19), fueled by the emergence of viral variants. At the same time, […]
Improvement of immune dysregulation in individuals with long COVID at 24-months following SARS-CoV-2 infection
Chansavath Phetsouphanh, Brendan Jacka, et. al., Nature Communications volume 15, Article number: 3315 (2024) Abstract This study investigates the humoral and cellular immune responses and health-related quality of life measures in individuals with mild to moderate long […]