Neurology and neuropsychiatry of COVID-19: a systematic review and meta-analysis of the early literature reveals frequent CNS manifestations and key emerging narratives

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Authors: Jonathan P Rogers1,2, Cameron J Watson3, et.al Abstract There is accumulating evidence of the neurological and neuropsychiatric features of infection with SARS-CoV-2. In this systematic review and meta-analysis, we aimed to describe the characteristics of the early literature and estimate point prevalences for neurological and neuropsychiatric manifestations. We searched MEDLINE, Embase, PsycINFO and CINAHL up to […]

The potential neurological effect of the COVID-19 vaccines: A review

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Authors: Lu Lu 1 2, Weixi Xiong 1 2, Jie Mu 1 2, Qi Zhang 1 2, Hesheng Zhang 1 2, Ling Zou 3, Weimin Li 4, Li He 1 2, Josemir W Sander 1 2 5 6, Dong Zhou 1 2 Abstract The coronavirus disease 2019 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic with people infected in almost all countries. The most efficient solution to end this pandemic is a safe and efficient vaccine. Classic platforms […]

India’s Ivermectin Blackout

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Authors: Authored by Justus R Hope, MD. via TheDesertReview.com, Ivermectin Wins in India News of India’s defeat of the Delta variant should be common knowledge. It is just about as obvious as the nose on one’s face. It is so clear when one looks at the graphs that no one can deny it. Yet, for […]

Ivermectin for COVID-19: real-time meta analysis of 63 studies

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Authors: Covid Analysis, Aug 12, 2021, Version 109 — twitter personality response, added Together Trial (V1 Nov 26, 2020) •Meta analysis using the most serious outcome reported shows 73% and 86% improvement for early treatment and prophylaxis (RR 0.27 [0.16-0.44] and 0.14 [0.08-0.25]), with similar results after exclusion based sensitivity analysis, restriction to peer-reviewed studies, restriction to serious outcomes, and restriction to Randomized Controlled Trials.•61% and […]

New Covid-19 Hospitalizations for 30- to 39-Year-Olds at Record Rate

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Group largely avoided hospitals earlier in pandemic, but highly contagious Delta variant and lagging vaccination rates have changed health outcomes Authors: By Melanie Evans and Taylor Umlauf Hospitalizations of Covid-19 patients in their 30s have hit a new record, U.S. government data show, a sign of the toll that the highly contagious Delta variant is taking among the unvaccinated. Thirty-somethings, […]

Trained Innate Immunity, Epigenetics, and Covid-19

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Authors: Alberto Mantovani, M.D., and Mihai G. Netea, M.D. Innate immunity is mediated by different cell types and cell-associated or fluid-phase pattern-recognition molecules and plays a key role in tissue repair and resistance against pathogens.1 Exposure to selected vaccines, such as bacille Calmette–Guérin (BCG) or microbial components, can increase the baseline tone of innate immunity and trigger […]

Multi-layered transcriptomic analyses reveal an immunological overlap between COVID-19 and hemophagocytic lymphohistiocytosis associated with disease severity

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Authors: Lena F. Schimkea,5, Alexandre H.C. Marquesa, Gabriela Crispim Baiocchia, Caroline Aliane de Souza Pradob Dennyson Leandro M. Fonsecab , Paula Paccielli Freirea , Desirée Rodrigues Plaçab , Igor Salerno Filgueirasa ,Ranieri Coelho Salgadoa, Gabriel Jansen-Marquesc, Antonio Edson Rocha liveirab, Jean PierreSchatzmann Perona, José Alexandre Marzagão Barbutoa,d, Niels Olsen Saraiva Camaraa, Vera Lúcia Garcia Calicha […]

Good news: Mild COVID-19 induces lasting antibody protection

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People who have had mild illness develop antibody–producing cells that can last lifetime Authors: by Tamara Bhandari•May 24, 2021 Months after recovering from mild cases of COVID-19, people still have immune cells in their body pumping out antibodies against the virus that causes COVID-19, according to a study from researchers at Washington University School of Medicine […]

COVID-19 Science Update released: June 4, 2021 Edition 92

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Authors: From the Office of the Chief Medical Officer, CDC COVID-19 Response, and the CDC Library, Atlanta GA. Intended for use by public health professionals responding to the COVID-19 pandemic. PEER-REVIEWED Safety, immunogenicity, and efficacy of the BNT162b2 COVID-19 vaccine in adolescents.external icon Frenck et al. NEJM (May 27, 2021). Key findings: Vaccine efficacy was 100% (95% CI 75.3%-100%) […]

SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

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Authors: Jackson S. Turner, Wooseob Kim, Elizaveta Kalaidina, Charles W. Goss, Adriana M. Rauseo, Aaron J. Schmitz, Lena Hansen, Alem Haile, Michael K. Klebert, Iskra Pusic, Jane A. O’Halloran, Rachel M. Presti & Ali H. Ellebedy  Abstract Long-lived bone marrow plasma cells (BMPCs) are a persistent and essential source of protective antibodies1,2,3,4,5,6,7. Individuals who have recovered from COVID-19 have a substantially lower risk of reinfection with SARS-CoV-28,9,10. Nonetheless, […]