New study reveals insights into COVID-19 antibody response durability

University of Maryland School of Medicine, 2024 Researchers at the Institute of Human Virology (IHV) at the University of Maryland School of Medicine have published a new study in the Journal of Infectious Diseases investigating the antibody response following SARS-CoV-2 infection. Long-lived plasma cells are responsible for durable antibody responses that persist for decades after immunization or infection. For example, infection […]

Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage

Authors: Yan-Mei ChenYuanting ZhengYing YuYunzhi WangQingxia HuangFeng QianLei SunZhi-Gang SongZiyin ChenJinwen FengYanpeng AnJingcheng YangZhenqiang SuShanyue SunFahui DaiQinsheng ChenQinwei LuPengcheng LiYun LingZhong YangHuiru TangLeming ShiLi JinEdward C HolmesChen DingTong-Yu ZhuYong-Zhen Zhang Abstract COVID-19 is characterized by dysregulated immune responses, metabolic dysfunction and adverse effects on the function of multiple organs. To understand host responses to COVID-19 […]

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection

Authors: Lina Ma1, View ORCID ProfileSanjaya K. Sahu1, View ORCID ProfileMarlene Cano1, Vasanthan Kuppuswamy2, Jamal Bajwa1,3, View ORCID ProfileJa’Nia McPhatter1,4 Complement activation has been implicated in the pathogenesis of severe SARS-CoV-2 infection. However, it remains to be determined whether increased complement activation is a broad indicator of critical illness (and thus, no different in COVID-19). It is also unclear which […]