Scientists push back on call to endorse booster shots for all

Authors: By Ariel Hart,  Helena Oliviero– The Atlanta Journal-Constitution Responding to the resurging pandemic and breakthrough infections, President Biden and some top health officials are pushing for the U.S. to begin vaccine booster shots by Sept. 20. But the committee of scientists who officially recommend whether to take such steps met Monday and pushed back. The […]

Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines

Authors: Bryant, Andrew MSc1,*; Lawrie, Theresa A. MBBCh, PhD2; Dowswell, Therese PhD2; Fordham, Edmund J. PhD2; Mitchell, Scott MBChB, MRCS3; Hill, Sarah R. PhD1; Tham, Tony C. MD, FRCP4 American Journal of Therapeutics: July/August 2021 – Volume 28 – Issue 4 – p e434-e460doi: 10.1097/MJT.0000000000001402 Abstract Background:  Repurposed medicines may have a role against the SARS-CoV-2 virus. The […]

Anticoagulation in COVID-19: current concepts and controversies

Authors: Chandra1, 6289Uddalak Chakraborty2, Shrestha Ghosh1, Sugata Dasgupta3 Abstract Rising incidence of thromboembolism secondary to COVID-19 has become a global concern, with several surveys reporting increased mortality rates. Thrombogenic potential of the SARS-CoV-2 virus has been hypothesised to originate from its ability to produce an exaggerated inflammatory response leading to endothelial dysfunction. Anticoagulants have remained the primary […]

COVID-19 One Year Later

Authors: Giuseppe Novelli, Michela Biancolella, Ruty Mehrian-Shai, Vito Luigi Colona, Anderson F. Brito, Nathan D. Grubaugh, Vasilis Vasiliou, Lucio Luzzatto & Juergen K. V. Reichardt  COVID-19 has engulfed the world and it will accompany us all for some time to come. Here, we review the current state at the milestone of 1 year into the pandemic, as declared by the WHO (World Health Organization). […]

Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

Authors: Romina Libster, M.D., Gonzalo Pérez Marc, M.D., Diego Wappner, M.D., Silvina Coviello, M.S., Alejandra Bianchi, Virginia Braem, Ignacio Esteban, M.D., Mauricio T. Caballero, M.D., Cristian Wood, M.D., Mabel Berrueta, M.D., Aníbal Rondan, M.D., Gabriela Lescano, M.D., et al., for the Fundación INFANT–COVID-19 Group* Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, […]

Returning to physical activity after covid-19

Authors: David Salman, academic clinical fellow in primary care12,  Dane Vishnubala, consultant in sports and exercise medicine and honorary senior lecturer in primary care and public health23,  Peter Le Feuvre, military physiotherapist and research fellow in complex trauma rehabilitation15,  Thomas Beaney, academic clinical fellow in primary care2,  Jonathan Korgaonkar, consultant in sports and exercise medicine4, […]

Coronavirus Recovery: Breathing Exercises

Authors: Peiting Lien, DPT, PT The coronavirus that causes COVID-19 attacks the lungs and respiratory system, sometimes resulting in significant damage. COVID-19 often leads to pneumonia and even acute respiratory distress syndrome (ARDS), a severe lung injury. Recovering lung function is possible but can require therapy and exercises for months after the infection is treated. “Working toward recovery […]

The hallmarks of COVID-19 disease

Authors: Daolin Tang ,Paul Comish,Rui Kang  Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus that has caused a worldwide pandemic of the human respiratory illness COVID-19, resulting in a severe threat to public health and safety. Analysis of the genetic tree suggests that SARS-CoV-2 belongs to the same Betacoronavirus group as severe acute respiratory syndrome coronavirus […]

Interim Clinical Guidance for Management of Patients with Confirmed Coronavirus Disease (COVID-19)

Authors: CDC New information on potential for under-detection of occult hypoxemia by pulse oximetry, especially among persons with dark skin New information on dermatologic manifestations associated with COVID-19 New information on prolonged shedding of replication-competent SARS-CoV-2 in severely immunocompromised persons New information on reports of reinfection with variant viruses Clinical Presentation, Clinical Course, Laboratory and […]

Considerations for Certain Concomitant Medications in Patients With COVID-19

Authors: NIH Patients with COVID-19 who are receiving concomitant medications (e.g., angiotensin-converting enzyme [ACE] inhibitors, angiotensin receptor blockers [ARBs], statins, systemic or inhaled corticosteroids, nonsteroidal anti-inflammatory drugs, acid-suppressive therapy) for underlying medical conditions should not discontinue these medications during acute management of COVID-19 unless discontinuation is otherwise warranted by their clinical condition (AIIa for ACE inhibitors and […]