Category: Megakaryocytes

SARS-CoV-2 infection modifies the transcriptome of the megakaryocytes in the bone marrow

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Isabelle Allaeys, Guillaume Lemaire, Mickaël Leclercq, et. al. Blood Adv (2024) 8 (11): 2777–2789. Megakaryocytes (MKs), integral to platelet production, predominantly reside in the bone marrow (BM) and undergo regulated fragmentation within sinusoid vessels to release platelets into the bloodstream. Inflammatory states and infections influence MK transcription, potentially affecting platelet functionality. Notably, COVID-19 has been associated […]

Indiana University researchers study long-term effects of COVID-19 on bone growth

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Authors: Caitlin VanOverberghe  SARS-CoV-2 can cause quick and significant bone loss—even when infections of the virus that causes COVID-19 appear to be mild. Researchers in the Department of Orthopaedic Surgery at Indiana University School of Medicine discovered that mouse models infected with the novel coronavirus lost approximately 25% of their bone mass within two weeks of contagion. […]