Distinct immune, hormone responses shed light on mysteries of long COVID


People who have experienced symptoms for months or longer after being infected exhibit different immune and hormonal responses to the virus, a new study finds. By Bill Hathaway, September 25, 2023 Yale News People who have experienced brain fog, confusion, pain, and extreme fatigue for months or longer after being infected with the COVID-19 virus […]

Long Covid: MRI scans reveal new clues to symptoms


September 24, 2023 By Dominic Hughes, Health correspondent, BBC News People living with long Covid after being admitted to hospital are more likely to show some damage to major organs, according to a new study. MRI scans revealed patients were three times more likely to have some abnormalities in multiple organs such as the lungs, […]

Long COVID scientists try to unravel blood clot mystery


May 15, 202312:15 AM ET By Anil Oza, Rebecca Ramirez, Emily Kwong, Gabriel Spitzer, Margaret Cirino, Berly McCoy, https://www.npr.org/2023/05/10/1175217130/long-covid-scientists-try-to-unravel-blood-clot-mystery As part of studying long COVID, graduate researcher Bradley Wade Hamilton separates out microclots from blood platelets in a solution. The federal COVID-19 public health emergency ended last week, but millions in the U.S. — and across the globe — are still dealing […]

Blood Clotting Proteins Might Help Predict Long COVID Brain Fog


New research suggests that blood clotting from COVID infections could contribute to long-term brain fog and other cognitive issues By Sara Reardon on September 1, 2023 Scientific American Many people who have long COVID—a condition in which health issues persist months after infection—report struggling with “brain fog,” recurring memory and concentration lapses that make it difficult­­ to function […]

Increased risk of chronic fatigue and hair loss following COVID-19 in individuals with hypohidrotic ectodermal dysplasia


Verena Hennig, Wolfgang Schuh, Antje Neubert, Dirk Mielenz, Hans-Martin Jäck & Holm Schneider Orphanet Journal of Rare Diseases volume 16, Article number: 373 (2021) Cite this article Abstract Background Hypohidrotic ectodermal dysplasia (HED) is a group of genodermatoses in which deficient ectodysplasin A signalling leads to maldevelopment of skin appendages, various eccrine glands, and teeth. Individuals with HED often have disrupted epithelial barriers and, therefore, were suspected to […]

An overview of human proteins and genes involved in SARS-CoV-2 infection


Zohreh Jahanafrooz,a,⁎ Zhishan Chen,b Jiandong Bao,c Hongzhi Li,d Loren Lipworth,b and Xingyi Guob,e,⁎Gene. 2022 Jan 15; 808: 145963. Published online 2021 Sep 14. doi: 10.1016/j.gene.2021.145963 PMCID: PMC8437745PMID: 34530086 Graphical abstract A summarized view of recent findings of host proteins interacting with SARS-CoV-2 and genes containing associated variants with COVID-19 susceptibility and severity. The left side of the figure (A) shows host protein interactors (blue wrote) for […]

Disruption of the blood-brain barrier due to long COVID


Bhavana Kunkalikar Jan 27 2023 Reviewed by Aimee Molineux, https://doi.org/10.21203/rs.3.rs-2069710/v2 In a recent study posted to the Research Square* preprint server, researchers explored the destruction of the blood-brain barrier (BBB) due to cognitive impairment associated with long coronavirus disease (COVID). Background Studies have demonstrated microvascular injuries observed in the brains of deceased severe acute respiratory syndrome coronavirus 2 […]

Saliva changes in composition associated to COVID-19: a preliminary study


Alberto Muñoz-Prieto, Ivana Rubić, Juan Carlos Gonzalez-Sanchez, Josipa Kuleš, Silvia Martínez-Subiela, José Joaquín Cerón, Enrique Bernal, Alberto Torres-Cantero, María Rosario Vicente-Romero, Vladimir Mrljak & Asta Tvarijonaviciute  Scientific Reports volume 12, Article number: 10879 (2022) Cite this article Abstract The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2), is usually associated with a wide variety of clinical presentations from asymptomatic to severe cases. The use of […]

Alopecia Areata after COVID-19 Vaccines


Lucia Genco,* Mariateresa Cantelli, Matteo Noto, Teresa Battista, Angela Patrì, Gabriella Fabbrocini, and Maria Vastarella Skin Appendage Disord. 2023 Mar; 9(2): 141–143. Published online 2023 Jan 19. doi: 10.1159/000528719 PMCID: PMC9892995 PMID: 36926281 Abstract Introduction Alopecia areata (AA) is a common autoimmune disease characterized by non-scarring hair loss. New onsets of AA have been associated with coronavirus disease 2019 (COVID-19). Various skin diseases have already been […]

Structural biology of SARS-CoV-2 and implications for therapeutic development


Haitao Yang & Zihe Rao  Nature Reviews Microbiology volume 19, pages685–700 (2021) Cite this article Abstract The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an unprecedented global health crisis. However, therapeutic options for treatment are still very limited. The development of drugs that target vital proteins in the viral life cycle is a feasible approach […]