COVID-19 Vasculopathy: Mounting Evidence for an Indirect Mechanism of Endothelial Injury

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Authors: Roberto F. Nicosia,∗∗ Giovanni Ligresti,† Nunzia Caporarello,‡ Shreeram Akilesh,∗ and Domenico Ribatti§ Patients with coronavirus disease 2019 (COVID-19) who are critically ill develop vascular complications characterized by thrombosis of small, medium, and large vessels. Dysfunction of the vascular endothelium due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been implicated in the pathogenesis of the COVID-19 […]

Endothelial dysfunction contributes to COVID-19-associated vascular inflammation and coagulopathy

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Authors: Jun Zhang 1, Kristen M Tecson 1, Peter A McCullough 1 2 3 Great attention has been paid to endothelial dysfunction (ED) in coronavirus disease 2019 (COVID-19). There is growing evidence to suggest that the angiotensin converting enzyme 2 receptor (ACE2 receptor) is expressed on endothelial cells (ECs) in the lung, heart, kidney, and intestine, particularly in systemic vessels (small and […]

Endothelial dysfunction in COVID-19: Current findings and therapeutic implications

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Authors: Matthias P Nägele 1, Bernhard Haubner 1, Felix C Tanner 1, Frank Ruschitzka 1, Andreas J Flammer 2 Coronavirus disease 2019 (COVID-19) increases the risk of several non-pulmonary complications such as acute myocardial injury, renal failure or thromboembolic events. A possible unifying explanation for these phenomena may be the presence of profound endothelial dysfunction and injury. This review provides an overview on the […]

Mutational Similarities Between SARS-CoV-2 and Its Predecessors

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Authors: | Original story from University of Nebraska–Lincoln, Credit: Pete Linforth/ Pixabay New research from the University of Nebraska-Lincoln has shown that the mutations arising in the COVID-19-causing SARS-CoV-2 virus seem to run in the family — or at least the genus of coronaviruses most dangerous to humans. After comparing the early evolution of SARS-CoV-2 against […]

How Precision Medicine, Genomics Research is Decoding COVID-19

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Authors:  Jessica Kent Studies have sought to discover why the disease affects some individuals more severely than others, how communities can reduce the spread of infection, and which states or cities will likely see a surge of new cases. A critical feature of this research – and the key to achieving an enhanced understanding of […]

SARS-CoV-2 genomics and host cellular susceptibility factors of COVID-19

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Authors: FENGYU ZHANG AND MICHAEL D WATERS Coronavirus disease 19 (COVID-19) caused by infection with a novel severe acute respiratory syndrome virus -2 (SARS-CoV-2) has evolved into a pandemic and a global public health emergency. The viral genomics, host cellular factors, and interactions are critical for establishing a viral infection and developing a related disease. […]

Primed” for Infection: Cells Damaged by Chronic Lung Disease Can Result in Severe COVID

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Authors: TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (TGEN) Results from a TGen-led international study suggest that SARS-CoV-2 takes advantage of genetic changes among patients with pre-existing lung diseases. The results of a study by an international scientific team co-led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest that — like pouring water atop […]

SARS-CoV-2 viral genomics

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Authors: This analysis was performed primarily by Matt Olm (mattolm@stanford.edu) in Justin Sonnenburg’s lab at Stanford University and Alex Crits-Christoph (crits-christoph@berkeley.edu) in Jill Banfield’s lab at University of California, Berkeley As viruses replicate within their hosts during infection, they mutate and accrue genetic diversity in their populations. These populations are usually shared as a single […]

Covid-19: links between genes and disease severity

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Authors: Bolzano research centre In March 2020, thousands of scientists around the world joined forces to investigate the questions at the forefront of the medical debate on the pandemic: what genetic factors influence the severity of Covid-19 infections and why do some people develop a serious illness that requires hospitalisation while others have mild or […]

Covid-19 versus genomics and other advanced technologies

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Authors: Heidi Vella Genome sequencing, big data and artificial intelligence are helping doctors to better understand, treat and hopefully beat Covid-19. The global scientific response to the novel coronavirus pandemic, which so far has killed over 328,000 people worldwide, is unprecedented. On 10 January 2020, nine days after the first cases of suspected Covid-19 were identified, the […]