Long covid: How to define it and how to manage it


Authors: Nikki Nabavi, editorial scholar “Profound fatigue” was a common symptom in most people with long covid, she said, but added that a wide range of other symptoms included cough, breathlessness, muscle and body aches, and chest heaviness or pressure, but also skin rashes, palpitations, fever, headache, diarrhoea, and pins and needles. “A very common […]

Coronavirus 2019 (COVID-19)- Using Ascorbic Acid and Zinc Supplementation (COVIDAtoZ)


Authors: Milind Desai, M. D, Suma Thomas Principal Investigators: The Cleveland Clinic A Clinical Trail to see whether ascorbic acid and zinc gluconate which has limited side effect profile and is readily available over the counter can decrease the duration of symptoms seen in patients with new diagnosis of COVID-2019. A secondary purpose is to […]

Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study


Authors: Tao Chen, doctor1,  Di Wu, doctor1,  Huilong Chen, doctor1,  Weiming Yan, research associate1,  Danlei Yang, doctor2,  Guang Chen, doctor1,  Ke Ma, doctor1,  Dong Xu, doctor1,  Haijing Yu, doctor1,  Hongwu Wang, doctor1,  Tao Wang, doctor2,  Wei Guo, doctor1,  Jia Chen, doctor1,  Chen Ding, doctor1,  Xiaoping Zhang, doctor1,  Jiaquan Huang, doctor1,  Meifang Han, doctor1,  Shusheng Li, […]

The hallmarks of COVID-19 disease


Authors: Daolin Tang ,Paul Comish,Rui Kang  Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus that has caused a worldwide pandemic of the human respiratory illness COVID-19, resulting in a severe threat to public health and safety. Analysis of the genetic tree suggests that SARS-CoV-2 belongs to the same Betacoronavirus group as severe acute respiratory syndrome coronavirus […]

Persistent Symptoms in Patients After Acute COVID-19


Authors: Angelo Carfì, MD1; Roberto Bernabei, MD1; Francesco Landi, MD, PhD1; et al In Italy, a large proportion of patients with coronavirus disease 2019 (COVID-19) presented with symptoms (71.4% of 31 845 confirmed cases as of June 3, 2020).1 Common symptoms include cough, fever, dyspnea, musculoskeletal symptoms (myalgia, joint pain, fatigue), gastrointestinal symptoms, and anosmia/dysgeusia.2–4 However, information is lacking on symptoms that persist after recovery. We assessed […]

Interim Clinical Guidance for Management of Patients with Confirmed Coronavirus Disease (COVID-19)


Authors: CDC New information on potential for under-detection of occult hypoxemia by pulse oximetry, especially among persons with dark skin New information on dermatologic manifestations associated with COVID-19 New information on prolonged shedding of replication-competent SARS-CoV-2 in severely immunocompromised persons New information on reports of reinfection with variant viruses Clinical Presentation, Clinical Course, Laboratory and […]

Pathology and Pathogenesis of SARS-CoV-2 Associated with Fatal Coronavirus Disease, United States


Authors: Roosecelis B. Martines, Jana M. Ritter1, Eduard Matkovic, Joy Gary, Brigid C. Bollweg, Hannah Bullock, Cynthia S. Goldsmith, Luciana Silva-Flannery, Josilene N. Seixas, Sarah Reagan-Steiner, Timothy Uyeki, Amy Denison, Julu Bhatnagar, Wun-Ju Shieh, Sherif R. Zaki, and COVID-19 Pathology Working Group An ongoing pandemic of coronavirus disease (COVID-19) is caused by infection with severe […]

Top Ten COVID-19 Anxiety Reduction Strategies


Authors: Ken Goodman, LCSW To stop the spread of COVID-19, we’ve had to practice social distancing. But to stop the spread of anxiety, we must distance ourselves from the media. All anxiety stems from uncertainty and an active imagination which produces catastrophic thoughts. The media, which is 24/7 Coronavirus and virtually all negative, is the […]

Considerations for Certain Concomitant Medications in Patients With COVID-19


Authors: NIH Patients with COVID-19 who are receiving concomitant medications (e.g., angiotensin-converting enzyme [ACE] inhibitors, angiotensin receptor blockers [ARBs], statins, systemic or inhaled corticosteroids, nonsteroidal anti-inflammatory drugs, acid-suppressive therapy) for underlying medical conditions should not discontinue these medications during acute management of COVID-19 unless discontinuation is otherwise warranted by their clinical condition (AIIa for ACE inhibitors and […]

Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity and Progression


Authors: Mary Kathryn Bohn, Alexandra Hall, Lusia Sepiashvili, Benjamin Jung, Shannon Steele, and Khosrow Adeli Abstract The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the pathophysiological mechanisms underlying disease severity and progression remain unclear. This […]