SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

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Authors: Yuyang Lei, Jiao Zhang, Cara R. Schiavon, Ming He, Lili Chen, Hui Shen, Yichi Zhang, Qian Yin, Yoshitake Cho, Leonardo Andrade, Gerald S. Shadel, Mark Hepokoski, Ting Lei, Hongliang Wang, Jin Zhang, Jason X., et. al. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection relies on the binding of S protein (Sprotein (Spike glycoprotein) to ACE (angiotensin-converting enzyme) 2 in the host cells. Vascular endothelium can be infected by […]

Former VP of Pfizer warns of government lies about Covid and the dangers of the vaccine ostensibly designed to combat it

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Authors: Gerard Clarke The Former Vice President of Pfizer, Dr. Michael Yeadon, has said that there is “demonstrably false” propaganda coming from governments in response to COVID-19, including the “lie” of dangerous variants and the totalitarian potential for “vaccine passports”. In an exclusive interview with LifeSite News, Dr. Yeadon, who was the Chief Scientist for […]

Researcher: ‘We Made a Big Mistake’ on COVID-19 Vaccine

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Authors: Dr. Joseph Mercola Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., has gained access to Pfizer’s biodistribution study from the Japanese regulatory agency. The research, previously unseen, demonstrates a huge problem with all COVID-19 vaccines The assumption that vaccine developers have been working with is that the mRNA in the vaccines would primarily remain […]

COVID-19: A Mitochondrial Perspective

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Authors: Pankaj Prasun 1 Coronavirus disease 2019 (COVID-19) is the worst public health crisis of the century. Although we have made tremendous progress in understanding the pathogenesis of this disease, a lot more remains to be learned. Mitochondria appear to be important in COVID-19 pathogenesis because of its role in innate antiviral immunity, as well as […]

Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis

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Authors: Keshav K. Singh,* Gyaneshwer Chaubey,* Jake Y. Chen, and Prashanth Suravajhala Because of the ongoing pandemic around the world, the mechanisms underlying the SARS-CoV-2-induced COVID-19 are subject to intense investigation. Based on available data for the SARS-CoV-1 virus, we suggest how CoV-2 localization of RNA transcripts in mitochondria hijacks the host cell’s mitochondrial function to viral advantage. […]

COVID-19 Autopsies Put Endothelial Damage, Angiogenesis in the Spotlight

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Authors: L.A. McKeown NEWSDaily News COVID-19 Autopsies Put Endothelial Damage, Angiogenesis in the Spotlight The still-forming picture suggests significantly more new-vessel growth in the lung than would be expected from a typical flu. byL.A. McKeown More autopsy reports on COVID-19 patients, some from the United States, are helping researchers piece together a picture of a […]

Clots, Strokes and Rashes: Is COVID a Disease of the Blood Vessels?

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Authors: Will Stone Whether it’s strange rashes on the toes or blood clots in the brain, the widespread ravages of COVID-19 have increasingly led researchers to focus on how the novel coronavirus sabotages blood vessels. As scientists have come to know the disease better, they have homed in on the vascular system — the body’s […]

The Thorny Problem Of COVID-19 Vaccines And Spike Proteins

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Authors: W. Glen Pyle Almost since the beginning of the COVID-19 pandemic, a piece of the SARS-CoV2 virus called the “spike protein” has drawn interest from researchers and healthcare professionals. New research by Yuyang Lei and colleagues published in the journal Circulation Research sheds new light on how the spike protein might play a critical role in […]

Evidence Shows that COVID-19 Attacks Blood Vessels

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Authors: Carolyn Crist As researchers learn more about COVID-19, they’ve seen reports from patients about unusual rashes, blood clots, and strokes, which could all be linked to damaged blood vessels. Scientists are now looking at the vascular system, which includes arteries, veins, and capillaries, to monitor the various ways that the coronavirus attacks the body, […]

COVID-19 is, in the end, an endothelial disease

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Authors: Peter Libby, Thomas Lüscher The vascular endothelium provides the crucial interface between the blood compartment and tissues, and displays a series of remarkable properties that normally maintain homeostasis. This tightly regulated palette of functions includes control of haemostasis, fibrinolysis, vasomotion, inflammation, oxidative stress, vascular permeability, and structure. While these functions participate in the moment-to-moment regulation […]