Individual differences in adolescent mental health during COVID-19: The importance of peer relationship quality

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By DocWire News Featured Reading -August 11, 2021 Neuron. 2021 Aug 9:S0896-6273(21)00571-7. doi: 10.1016/j.neuron.2021.07.027. Online ahead of print. ABSTRACT Lockdowns and school closures deprive adolescents of typical social interactions. In this NeuroView, we explore how the quality of existing peer relationships might moderate-both positively and negatively-the impact of these restrictions on adolescent mental health, and we highlight […]

Stress-Related Growth in Adolescents Returning to School After COVID-19 School Closure

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Authors: Lea Waters1*, Kelly-Ann Allen1,2 and Gökmen Arslan3,4 The move to remote learning during COVID-19 has impacted billions of students. While research shows that school closure, and the pandemic more generally, has led to student distress, the possibility that these disruptions can also prompt growth in is a worthwhile question to investigate. The current study examined stress-related growth […]

Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19

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Authors: MartinDugasa1TanjaGrote-Westrickb1UtaMerledMichaelaFontenaylmAndreas E.KremerhFrankHansesijRichardVollenbergcEvaLorentzenbShilpaTiwari-BecklerdJérômeDucheminlSyrineEllouzelMarcelVetterhJuliaFürsthPhilippSchusterkTobiasBrixaClaudia M.DenkingerfgCarstenMüller-TidoweHartmutSchmidtc…JoachimKühnb1 Highlights Does prior infection with seasonal human coronavirus OC43 protect against critical COVID-19?• Findings: In an international multi-center study inpatients without anti-HCoV OC43 NP antibodies had an increased risk of critical disease.• Meaning: Prior infections with seasonal HCoV OC43 have a protective effect against critical COVID-19. Abstract Background The vast majority of COVID-19 patients experience […]

What is OC43?

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Authors: By Benedette Cuffari, M.Sc.Reviewed by Emily Henderson, B.Sc. In an effort to further understand and predict the health effects that can arise following infection by SARS-CoV-2, which is the infection that causes the disease COVID-19, many researchers have reevaluated the pathogenesis associated with coronaviruses that have already been identified. One type of coronavirus that has infected individuals around […]

Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19

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Authors: Martin Dugas 1, Tanja Grote-Westrick 2, Uta Merle 3, Michaela Fontenay 4, Andreas E Kremer 5, Frank Hanses 6, Richard Vollenberg 7, Eva Lorentzen 8, Shilpa Tiwari-Heckler 9, Jérôme Duchemin 10, Syrine Ellouze 11, Marcel Vetter 12, Julia Fürst 13, Philipp Schuster 14, Tobias Brix 15, Claudia M Denkinger 16, Carsten Müller-Tidow 17, Hartmut Schmidt 18, Phil-Robin Tepasse 19, Joachim Kühn 20 Abstract Background: The vast majority of COVID-19 patients experience a mild disease. However, a minority suffers from critical disease with substantial morbidity and mortality. Objectives: To identify individuals at risk of critical COVID-19, […]

PubChem

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OC43 Non-structural protein 2a NCBI Protein Q80872 Taxonomy Human coronavirus OC43 Dates Modify2021-08-11Create2017-04-15 UniProt 1Names and Identifiers 1.1Synonyms Non-structural protein 2a ns2a 32 kDa accessory protein 32 kDa non-structural protein ns2UniProt 1.2Other Identifiers 1.2.1UniProt ID Q80872UniProt 2Sequence >sp|Q80872|NS2A_CVHOC Non-structural protein 2a (Run BLAST) MAVAYADKPNHFINFPLTHFQGFVLNYKGLQFQILDEGVDCKIQTAPHISLTMLDIQPEDYKSVDVAIQEVIDDMHWGDGFQIKFENPHILGRCIVLDVKGVEELHDDLVNYIRDKGCVADQSRKWIGHCTIAQLTDAALSIKENVDFINSMQFNYKITINPSSPARLEIVKLGAEKKDGFYETIVSHWMGIRFEYTSPTDKLAMIMGYCCLDVVRKELEEGDLPENDDDAWFKLSYHYENNSWFFRHVYRKSFHFRKACQNLDCNCLGFYESPVEEDNCBI Protein For More Information: https://pubchem.ncbi.nlm.nih.gov/protein/Q80872

The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology

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Authors:Jenny K.Stodola1GuillaumeDubois1AlainLe CoupanecMarcDesforgesPierre J.Talbot Highlights Coronavirus structural envelope (E) protein specific motifs involved in protein-protein interaction or in homo-oligomeric ion channel formation are needed for optimal production of recombinant infectious virus.• Fully functional E protein of HCoV-OC43 is crucial for viral propagation in the CNS and neurovirulence.• Fully functional E protein of HCoV-OC43 is crucial […]

OC43 Membrane Protein Science

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UniProtKB – Q01455 (VME1_CVHOC) Entry Publications Feature viewer Feature table Function Names & Taxonomy Subcellular location Pathology & Biotech PTM / Processing Expression Interaction Structure Family & Domains Sequence Similar proteins Cross-references Entry information Miscellaneous TopBLASTAlignFormatAdd to basketHistory Membrane protein Gene M OrganismHuman coronavirus OC43 (HCoV-OC43)StatusReviewed-Annotation score:-Experimental evidence at protein leveli Functioni Component of the viral […]

Human coronavirus OC43 nucleocapsid protein binds microRNA 9 and potentiates NF-κB activation

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Authors: Frances W Lai 1, Kyle B Stephenson, James Mahony, Brian D Lichty Abstract The human coronavirus OC43 is a major contributor to the common cold worldwide, though due to its low mortality rate, little research has focused on this human pathogen. The nucleocapsid is an essential structural protein with conserved functions across the coronavirus family. While a multitude […]

Resolving “Long-Haul COVID” and Vaccine Toxicity: Neutralizing the Spike Protein

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Authors: Dr. Thomas E. Levy, MD, JD July 1, 2021 Although the mainstream media outlets might have you believe otherwise, the vaccines that continue to be administered for the COVID pandemic are emerging as substantial sources of morbidity and mortality themselves. While the degree to which these negative outcomes of the COVID vaccines can be debated, […]