Remdesivir for the Treatment of Covid-19 — Final Report

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Authors: John H. Beigel, M.D., Kay M. Tomashek, M.D., M.P.H., Lori E. Dodd, Ph.D., Aneesh K. Mehta, M.D., Barry S. Zingman, M.D., Andre C. Kalil, M.D., M.P.H., Elizabeth Hohmann, M.D., Helen Y. Chu, M.D., M.P.H., Annie Luetkemeyer, M.D., Susan Kline, M.D., M.P.H., Diego Lopez de Castilla, M.D., M.P.H., Robert W. Finberg, M.D., et al., for the ACTT-1 Study Group Members* Abstract BACKGROUND Although several therapeutic agents have been […]

Alert — EU looking into new side effects of Vaccine…

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Authors: By citizenfreepress.com Three new conditions reported by people after vaccination with shots from Pfizer and Moderna are being studied to assess if they may be possible side effects, Europe’s drug regulator said on Wednesday. Erythema multiforme, a form of allergic skin reaction; glomerulonephritis or kidney inflammation; and nephrotic syndrome, a renal disorder characterised by […]

How Will the Coronavirus Evolve?

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Authors: By Dhruv Khullar In 1988, Richard Lenski, a thirty-one-year-old biologist at UC Irvine, started an experiment. He divided a population of a common bacterium, E. coli, into twelve flasks. Each flask was kept at thirty-seven degrees Celsius, and contained an identical cocktail of water, glucose, and other nutrients. Each day, as the bacteria replicated, Lenski transferred several […]

Use of adenovirus type-5 vectored vaccines: a cautionary tale

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Authors: The Lancet We are writing to express concern about the use of a recombinant adenovirus type-5 (Ad5) vector for a COVID-19 phase 1 vaccine study,1 and subsequent advanced trials. Over a decade ago, we completed the Step and Phambili phase 2b studies that evaluated an Ad5 vectored HIV-1 vaccine administered in three immunizations for efficacy […]

From adenoviruses to RNA: the pros and cons of different COVID vaccine technologies

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Authors: Joel Abrams The World Health Organisation lists about 180 COVID-19 vaccines being developed around the world. Each vaccine aims to use a slightly different approach to prepare your immune system to recognise and fight SARS-CoV-2, the virus that causes COVID-19. However, we can group these technologies into five main types. Some technology is tried and trusted. […]

Here’s Why Viral Vector Vaccines Don’t Alter DNA

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— It’s pretty simple — they can’t Authors: by Veronica Hackethal, MD, MSc, Enterprise & Investigative Writer, MedPage Today March 12, 2021 Adenoviral vector vaccines have been in development for decades, but very few have been approved for use in humans. What does the history of adenoviral vector vaccine development tell us about their safety and their […]

More Dangerous Side Effects Potentially Linked To mRNA Vaccines, EU Warns

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Authors: BY TYLER DURDEN As shares of MRNA-vaccine purveyors Moderna and BioNTech tumbled on Wednesday, Reuters reported that the EMA, the EU’s medicines regulator, is looking into new potential side effects from the still-experimental MRNA jabs, including suspicious skin reactions and kidney ailments. According to Reuters, three new conditions have been reported by a small number […]

New data on coronavirus vaccine effectiveness may be “a wakeup call”

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Authors: Caitlin Owens A new preprint study that raises concerns about the mRNA vaccines’ effectiveness against Delta — particularly Pfizer’s — has already grabbed the attention of top Biden administration officials. What they’re saying: The study found the Pfizer vaccine was only 42% effective against infection in July, when the Delta variant was dominant. “If that’s not a wakeup call, […]

What Do We Really Know About Adenovirus Vectors for Vaccines?

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Authors: By Serena Marshall and Lara Salahi February 24, 2021 — The newest COVID shot uses an existing technology but one with lingering questions As the U.S. hits the half-million death mark from COVID-19 — a grim milestone that is equal to roughly the entire population of Atlanta and more than that of Miami — a new […]