Psychological Impact of COVID-19 on Children and Adolescents: A Systematic Review

Posted on | Posted on John Murphy | Leave a Comment on Psychological Impact of COVID-19 on Children and Adolescents: A Systematic Review

Authors: Nishtha Chawla,1Ashlyn Tom,1Mahadev Singh Sen,1 and Rajesh Sagar1 Abstract Background and aims: The outbreak of COVID-19 led to a significant psychological impact on individuals, particularly those belonging to vulnerable groups. This study aimed to synthesize literature on the psychological impact of COVID-19 among children and adolescents. Methods: Electronic search engines were used to identify studies till […]

Evaluation of the safety of mRNA-Moderna in adolescents

Posted on | Posted on John Murphy | Leave a Comment on Evaluation of the safety of mRNA-Moderna in adolescents

Authors: Killian Meara The vaccine demonstrated an acceptable safety profile in the adolescent population. A recent study conducted by investigators from the pharmaceutical and biotechnology company, Moderna, has found that their COVID-19 vaccine, mRNA-1273, was both safe and efficacious in preventing COVID-19 in adolescents. Results from the study were published in The New England Journal of […]

Individual differences in adolescent mental health during COVID-19: The importance of peer relationship quality

Posted on | Posted on John Murphy | Leave a Comment on Individual differences in adolescent mental health during COVID-19: The importance of peer relationship quality

By DocWire News Featured Reading -August 11, 2021 Neuron. 2021 Aug 9:S0896-6273(21)00571-7. doi: 10.1016/j.neuron.2021.07.027. Online ahead of print. ABSTRACT Lockdowns and school closures deprive adolescents of typical social interactions. In this NeuroView, we explore how the quality of existing peer relationships might moderate-both positively and negatively-the impact of these restrictions on adolescent mental health, and we highlight […]

Stress-Related Growth in Adolescents Returning to School After COVID-19 School Closure

Posted on | Posted on John Murphy | Leave a Comment on Stress-Related Growth in Adolescents Returning to School After COVID-19 School Closure

Authors: Lea Waters1*, Kelly-Ann Allen1,2 and Gökmen Arslan3,4 The move to remote learning during COVID-19 has impacted billions of students. While research shows that school closure, and the pandemic more generally, has led to student distress, the possibility that these disruptions can also prompt growth in is a worthwhile question to investigate. The current study examined stress-related growth […]

Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19

Posted on | Posted on John Murphy | Leave a Comment on Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19

Authors: MartinDugasa1TanjaGrote-Westrickb1UtaMerledMichaelaFontenaylmAndreas E.KremerhFrankHansesijRichardVollenbergcEvaLorentzenbShilpaTiwari-BecklerdJérômeDucheminlSyrineEllouzelMarcelVetterhJuliaFürsthPhilippSchusterkTobiasBrixaClaudia M.DenkingerfgCarstenMüller-TidoweHartmutSchmidtc…JoachimKühnb1 Highlights Does prior infection with seasonal human coronavirus OC43 protect against critical COVID-19?• Findings: In an international multi-center study inpatients without anti-HCoV OC43 NP antibodies had an increased risk of critical disease.• Meaning: Prior infections with seasonal HCoV OC43 have a protective effect against critical COVID-19. Abstract Background The vast majority of COVID-19 patients experience […]

What is OC43?

Posted on | Posted on John Murphy | Leave a Comment on What is OC43?

Authors: By Benedette Cuffari, M.Sc.Reviewed by Emily Henderson, B.Sc. In an effort to further understand and predict the health effects that can arise following infection by SARS-CoV-2, which is the infection that causes the disease COVID-19, many researchers have reevaluated the pathogenesis associated with coronaviruses that have already been identified. One type of coronavirus that has infected individuals around […]

Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19

Posted on | Posted on John Murphy | Leave a Comment on Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19

Authors: Martin Dugas 1, Tanja Grote-Westrick 2, Uta Merle 3, Michaela Fontenay 4, Andreas E Kremer 5, Frank Hanses 6, Richard Vollenberg 7, Eva Lorentzen 8, Shilpa Tiwari-Heckler 9, Jérôme Duchemin 10, Syrine Ellouze 11, Marcel Vetter 12, Julia Fürst 13, Philipp Schuster 14, Tobias Brix 15, Claudia M Denkinger 16, Carsten Müller-Tidow 17, Hartmut Schmidt 18, Phil-Robin Tepasse 19, Joachim Kühn 20 Abstract Background: The vast majority of COVID-19 patients experience a mild disease. However, a minority suffers from critical disease with substantial morbidity and mortality. Objectives: To identify individuals at risk of critical COVID-19, […]

PubChem

Posted on | Posted on John Murphy | Leave a Comment on PubChem

OC43 Non-structural protein 2a NCBI Protein Q80872 Taxonomy Human coronavirus OC43 Dates Modify2021-08-11Create2017-04-15 UniProt 1Names and Identifiers 1.1Synonyms Non-structural protein 2a ns2a 32 kDa accessory protein 32 kDa non-structural protein ns2UniProt 1.2Other Identifiers 1.2.1UniProt ID Q80872UniProt 2Sequence >sp|Q80872|NS2A_CVHOC Non-structural protein 2a (Run BLAST) MAVAYADKPNHFINFPLTHFQGFVLNYKGLQFQILDEGVDCKIQTAPHISLTMLDIQPEDYKSVDVAIQEVIDDMHWGDGFQIKFENPHILGRCIVLDVKGVEELHDDLVNYIRDKGCVADQSRKWIGHCTIAQLTDAALSIKENVDFINSMQFNYKITINPSSPARLEIVKLGAEKKDGFYETIVSHWMGIRFEYTSPTDKLAMIMGYCCLDVVRKELEEGDLPENDDDAWFKLSYHYENNSWFFRHVYRKSFHFRKACQNLDCNCLGFYESPVEEDNCBI Protein For More Information: https://pubchem.ncbi.nlm.nih.gov/protein/Q80872

The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology

Posted on | Posted on John Murphy | Leave a Comment on The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology

Authors:Jenny K.Stodola1GuillaumeDubois1AlainLe CoupanecMarcDesforgesPierre J.Talbot Highlights Coronavirus structural envelope (E) protein specific motifs involved in protein-protein interaction or in homo-oligomeric ion channel formation are needed for optimal production of recombinant infectious virus.• Fully functional E protein of HCoV-OC43 is crucial for viral propagation in the CNS and neurovirulence.• Fully functional E protein of HCoV-OC43 is crucial […]

OC43 Membrane Protein Science

Posted on | Posted on John Murphy | Leave a Comment on OC43 Membrane Protein Science

UniProtKB – Q01455 (VME1_CVHOC) Entry Publications Feature viewer Feature table Function Names & Taxonomy Subcellular location Pathology & Biotech PTM / Processing Expression Interaction Structure Family & Domains Sequence Similar proteins Cross-references Entry information Miscellaneous TopBLASTAlignFormatAdd to basketHistory Membrane protein Gene M OrganismHuman coronavirus OC43 (HCoV-OC43)StatusReviewed-Annotation score:-Experimental evidence at protein leveli Functioni Component of the viral […]