Disruption of the blood-brain barrier due to long COVID

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Bhavana Kunkalikar Jan 27 2023 Reviewed by Aimee Molineux, https://doi.org/10.21203/rs.3.rs-2069710/v2 In a recent study posted to the Research Square* preprint server, researchers explored the destruction of the blood-brain barrier (BBB) due to cognitive impairment associated with long coronavirus disease (COVID). Background Studies have demonstrated microvascular injuries observed in the brains of deceased severe acute respiratory syndrome coronavirus 2 […]

Saliva changes in composition associated to COVID-19: a preliminary study

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Alberto Muñoz-Prieto, Ivana Rubić, Juan Carlos Gonzalez-Sanchez, Josipa Kuleš, Silvia Martínez-Subiela, José Joaquín Cerón, Enrique Bernal, Alberto Torres-Cantero, María Rosario Vicente-Romero, Vladimir Mrljak & Asta Tvarijonaviciute  Scientific Reports volume 12, Article number: 10879 (2022) Cite this article Abstract The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2), is usually associated with a wide variety of clinical presentations from asymptomatic to severe cases. The use of […]

Alopecia Areata after COVID-19 Vaccines

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Lucia Genco,* Mariateresa Cantelli, Matteo Noto, Teresa Battista, Angela Patrì, Gabriella Fabbrocini, and Maria Vastarella Skin Appendage Disord. 2023 Mar; 9(2): 141–143. Published online 2023 Jan 19. doi: 10.1159/000528719 PMCID: PMC9892995 PMID: 36926281 Abstract Introduction Alopecia areata (AA) is a common autoimmune disease characterized by non-scarring hair loss. New onsets of AA have been associated with coronavirus disease 2019 (COVID-19). Various skin diseases have already been […]

Structural biology of SARS-CoV-2 and implications for therapeutic development

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Haitao Yang & Zihe Rao  Nature Reviews Microbiology volume 19, pages685–700 (2021) Cite this article Abstract The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an unprecedented global health crisis. However, therapeutic options for treatment are still very limited. The development of drugs that target vital proteins in the viral life cycle is a feasible approach […]

Headaches and COVID-19 Long-Haulers: What to Know

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September 16, 2021 / Brain & Spine The Cleveland Clinic Skull-pounding headaches can continue for weeks or even months after you test positive for COVID-19, with around-the-clock pain separated only by periods of agonizing and extreme spikes. It’s one of the most common symptoms being experienced by a group known as COVID-19 long-haulers, or those with lingering issues […]

UK scientists find link between proteins related to blood clots and long Covid

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Biomarker discovery indicates that sufferers from brain fog and fatigue post-virus could be treated with anticoagulants Oksana Pyzik 31 Aug 2023 The Guardian Scientists have identified molecular signatures in the blood that are linked to brain fog, other cognitive problems and fatigue in patients who are diagnosed with long Covid after catching the virus. Raised levels of […]

Serum vitamin D levels can be predictive of psoriasis flares up after COVID-19 vaccination: a retrospective case control study

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Emmanouil Karampinis1 George Goudouras1 Niki Ntavari1 Dimitrios Petrou Bogdanos2† Angeliki-Victoria Roussaki-Schulze1† Efterpi Zafiriou1*† Front. Med., 25 May 2023 Sec. Dermatology Volume 10 – 2023 | https://doi.org/10.3389/fmed.2023.1203426 Introduction: Many patients with chronic inflammatory dermatosis such as psoriasis usually ask about the safety of COVID-19 vaccination and if it would affect the course of their disease. Indeed, many case reports, case series and clinical […]

Scientists Gain Insight Into COVID’s Heart Impact

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(02 October 2023 Newsmax Health Day New research shows the COVID-19 virus can directly infect coronary arteries, inflaming fatty plaque inside them, which can increase the risk of heart disease and stroke. This may explain why some people who get COVID-19 have a greater chance of developing heart disease. It also may shed light on […]

New onset and exacerbation of psoriasis after COVID-19 vaccination

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Nancy Wei, BA,a,∗ Mindy Kresch, BS,b Emily Elbogen, PA-C,c and Mark Lebwohl, MDc JAAD Case Rep. 2022 Jan; 19: 74–77. Published online 2021 Nov 29. doi: 10.1016/j.jdcr.2021.11.016 PMCID: PMC8628636 PMID: 34869811 Introduction The messenger RNA (mRNA)-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech) vaccines were granted emergency use authorization during the ongoing COVID-19 pandemic by the United States Food and Drug Administration in December 2020.1 An adenoviral vector […]

Alteration of the blood-brain barrier by COVID-19 and its implication in the permeation of drugs into the brain

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Héctor Hernández-Parra1,2 Octavio Daniel Reyes-Hernández3 Gabriela Figueroa-González4 Manuel González-Del Carmen5 Maykel González-Torres6 Sheila I. Peña-Corona2 Benjamín Florán7 Hernán Cortés8* Gerardo Leyva-Gómez2* https://pubmed.ncbi.nlm.nih.gov/36998270/ Diverse neurological symptoms have been reported in patients with SARS-CoV-2 disease (COVID-19), including stroke, ataxia, meningitis, encephalitis, and cognitive impairment. These alterations can cause serious sequelae or death and are associated with the entry of SARS-CoV-2 into the Central Nervous System […]