Structural biology of SARS-CoV-2 and implications for therapeutic development

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Haitao Yang & Zihe Rao  Nature Reviews Microbiology volume 19, pages685–700 (2021) Cite this article Abstract The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an unprecedented global health crisis. However, therapeutic options for treatment are still very limited. The development of drugs that target vital proteins in the viral life cycle is a feasible approach […]

Headaches and COVID-19 Long-Haulers: What to Know

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September 16, 2021 / Brain & Spine The Cleveland Clinic Skull-pounding headaches can continue for weeks or even months after you test positive for COVID-19, with around-the-clock pain separated only by periods of agonizing and extreme spikes. It’s one of the most common symptoms being experienced by a group known as COVID-19 long-haulers, or those with lingering issues […]

UK scientists find link between proteins related to blood clots and long Covid

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Biomarker discovery indicates that sufferers from brain fog and fatigue post-virus could be treated with anticoagulants Oksana Pyzik 31 Aug 2023 The Guardian Scientists have identified molecular signatures in the blood that are linked to brain fog, other cognitive problems and fatigue in patients who are diagnosed with long Covid after catching the virus. Raised levels of […]

Serum vitamin D levels can be predictive of psoriasis flares up after COVID-19 vaccination: a retrospective case control study

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Emmanouil Karampinis1 George Goudouras1 Niki Ntavari1 Dimitrios Petrou Bogdanos2† Angeliki-Victoria Roussaki-Schulze1† Efterpi Zafiriou1*† Front. Med., 25 May 2023 Sec. Dermatology Volume 10 – 2023 | https://doi.org/10.3389/fmed.2023.1203426 Introduction: Many patients with chronic inflammatory dermatosis such as psoriasis usually ask about the safety of COVID-19 vaccination and if it would affect the course of their disease. Indeed, many case reports, case series and clinical […]

Scientists Gain Insight Into COVID’s Heart Impact

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(02 October 2023 Newsmax Health Day New research shows the COVID-19 virus can directly infect coronary arteries, inflaming fatty plaque inside them, which can increase the risk of heart disease and stroke. This may explain why some people who get COVID-19 have a greater chance of developing heart disease. It also may shed light on […]

New onset and exacerbation of psoriasis after COVID-19 vaccination

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Nancy Wei, BA,a,∗ Mindy Kresch, BS,b Emily Elbogen, PA-C,c and Mark Lebwohl, MDc JAAD Case Rep. 2022 Jan; 19: 74–77. Published online 2021 Nov 29. doi: 10.1016/j.jdcr.2021.11.016 PMCID: PMC8628636 PMID: 34869811 Introduction The messenger RNA (mRNA)-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech) vaccines were granted emergency use authorization during the ongoing COVID-19 pandemic by the United States Food and Drug Administration in December 2020.1 An adenoviral vector […]

Alteration of the blood-brain barrier by COVID-19 and its implication in the permeation of drugs into the brain

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Héctor Hernández-Parra1,2 Octavio Daniel Reyes-Hernández3 Gabriela Figueroa-González4 Manuel González-Del Carmen5 Maykel González-Torres6 Sheila I. Peña-Corona2 Benjamín Florán7 Hernán Cortés8* Gerardo Leyva-Gómez2* https://pubmed.ncbi.nlm.nih.gov/36998270/ Diverse neurological symptoms have been reported in patients with SARS-CoV-2 disease (COVID-19), including stroke, ataxia, meningitis, encephalitis, and cognitive impairment. These alterations can cause serious sequelae or death and are associated with the entry of SARS-CoV-2 into the Central Nervous System […]

Long COVID: The hunt for causes and cures

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With so many treatment candidates, researchers work to gain more clarity by Shi En Kim September 11, 2023 | A version of this story appeared in Volume 101, Issue 30 Hannah Davis misses her old self. Like so many people around the world, she has seen her life upended by long COVID, which has made many once-routine […]

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

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Suo-wen Xu, Iqra Ilyas & Jian-ping Weng Acta Pharmacologica Sinica volume 44, pages695–709 (2023) Nature Abstract The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However, the pathophysiology of acute and post-acute manifestations of COVID-19 (long COVID-19) is understudied. Endothelial cells are sentinels lining the innermost layer of blood vessel that gatekeep micro- and macro-vascular health by […]

The Most Important Question About Long COVID

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And why answering it holds the key to treating and preventing this condition and others like it By EKATERINA PESHEVA August 9, 2023 Research Harvard Medical School The underlying mechanisms fueling long COVID continue to bedevil researchers. The syndrome presents with remarkable variation across individuals and can involve different organs with varying degrees of severity. What causes […]