Alteration of the blood-brain barrier by COVID-19 and its implication in the permeation of drugs into the brain

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Héctor Hernández-Parra1,2 Octavio Daniel Reyes-Hernández3 Gabriela Figueroa-González4 Manuel González-Del Carmen5 Maykel González-Torres6 Sheila I. Peña-Corona2 Benjamín Florán7 Hernán Cortés8* Gerardo Leyva-Gómez2* https://pubmed.ncbi.nlm.nih.gov/36998270/ Diverse neurological symptoms have been reported in patients with SARS-CoV-2 disease (COVID-19), including stroke, ataxia, meningitis, encephalitis, and cognitive impairment. These alterations can cause serious sequelae or death and are associated with the entry of SARS-CoV-2 into the Central Nervous System […]

Long COVID: The hunt for causes and cures

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With so many treatment candidates, researchers work to gain more clarity by Shi En Kim September 11, 2023 | A version of this story appeared in Volume 101, Issue 30 Hannah Davis misses her old self. Like so many people around the world, she has seen her life upended by long COVID, which has made many once-routine […]

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

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Suo-wen Xu, Iqra Ilyas & Jian-ping Weng Acta Pharmacologica Sinica volume 44, pages695–709 (2023) Nature Abstract The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However, the pathophysiology of acute and post-acute manifestations of COVID-19 (long COVID-19) is understudied. Endothelial cells are sentinels lining the innermost layer of blood vessel that gatekeep micro- and macro-vascular health by […]

The Most Important Question About Long COVID

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And why answering it holds the key to treating and preventing this condition and others like it By EKATERINA PESHEVA August 9, 2023 Research Harvard Medical School The underlying mechanisms fueling long COVID continue to bedevil researchers. The syndrome presents with remarkable variation across individuals and can involve different organs with varying degrees of severity. What causes […]

Hearing Loss Is a Side Effect of COVID-19

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·April 14, 2023 Candy Gibson, Kim Gibson et al. BMJ Case Reports; Auditory Neuroscience Featured Neuroscience Summary: A link has been discovered between COVID-19 infection and sudden sensorineural hearing loss (SSHL). Upto one-third of patients referred to audiologists for SSHL were previously diagnosed with COVID-19. Other studies report an increase in SSHL in those with asymptomatic COVID-19 […]

COVID Tongue: How a Swollen Tongue Could Indicate COVID-19

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Should you be examining your tongue? Here’s how to tell if it’s COVID tongue and how to treat it. By  Korin Miller September 22, 2023; Medically reviewed by  Michael Menna, DO HEALTH You may have heard of COVID-19 causing loss of taste and smell, COVID toes, and unusual skin rashes, but did you know COVID can affect […]

Brainstem volume changes in myalgic encephalomyelitis/chronic fatigue syndrome and long COVID patients

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Kiran Thapaliya, 1 , 2 , * Sonya Marshall-Gradisnik, 1 Markus Barth, 2 , 3 Natalie Eaton-Fitch, 1 and Leighton Barnden 1 Front Neurosci. 2023; 17: 1125208. Published online 2023 Mar 2. doi: 10.3389/fnins.2023.1125208 PMCID: PMC10017877 PMID: 36937672 Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID patients have overlapping neurological, autonomic, pain, and post-exertional symptoms. We compared volumes of brainstem regions for 10 ME/CFS (CCC or ICC criteria), 8 long COVID (WHO […]

False, Misleading Information About COVID-19 Vaccines And Myocarditis Spreads Widely

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SEP 27, 2023 Authored by Zachary Stieber The Epoch Times  False and misleading information about COVID-19 vaccines and heart inflammation is being spread widely, including by doctors. That includes claims that data clearly show myocarditis, or heart inflammation, is more prevalent after COVID-19 infection when compared to COVID-19 vaccination. “Teen boys have been up to […]

A blood test for long Covid is possible, a study suggests

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Scientists can now show key differences in the blood of those who recover from Covid — and those who don’t. Sept. 25, 2023, 11:01 AM EDT By Erika Edwards NBC Health More than three years into the pandemic, the millions of people who have suffered from long Covid finally have scientific proof that their condition is […]

Vaccine-induced immune thrombotic thrombocytopenia

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BLOOD SPOTLIGHT| APRIL 6, 2023 Douglas B. Cines, Andreas Greinacher Blood (2023) 141 (14): 1659–1665. https://doi.org/10.1182/blood.2022017696 Within the first months of the COVID-19 vaccination campaign, previously healthy recipients who developed severe thrombosis (often cerebral and/or splanchnic vasculature) and thrombocytopenia typically after adenoviral vector-based vaccination were identified. Similarities between this syndrome, vaccine-induced immune thrombotic thrombocytopenia (VITT), and heparin-induced […]