Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments

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Akshita Gupta,1,2 Angelina Konnova,1,2 Mathias Smet,1,2 Matilda Berkell,1,2 Alessia Savoldi,3 Matteo Morra,3 Vincent Van averbeke,1 Fien H.R. De Winter,1 Denise Peserico,4 Elisa Danese,4 An Hotterbeekx,1 Elda Righi,3 mAb ORCHESTRA working group,5 Pasquale De Nardo,3 Evelina Tacconelli,3 Surbhi Malhotra-Kumar,2 and Samir Kumar-Singh1,2 Journal of Clinical Investigation 10.1172/JCI166032 Abstract Background. The role of host immunity in emergence of evasive SARS-CoV-2 Spike mutations under therapeutic monoclonal antibody (mAb) pressure remains to be explored. Methods. In a prospective, […]

Coffee as a dietary strategy to prevent SARS-CoV-2 infection

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Chen-Shiou Wu, Yi-Chuan Li, Shin-Lei Peng, Chung-Yu Chen, Hsiao-Fan Chen, Po-Ren Hsueh, Wei-Jan Wang, Yen-Yi Liu, Ciao-Ling Jiang, Wei-Chao Chang, Shao-Chun Wang & Mien-Chie Hung, Cell & Bioscience volume 13, Article number: 210 (2023)  Abstract Background To date, most countries lifted the restriction requirement and coexisted with SARS-CoV-2. Thus, dietary behavior for preventing SARS-CoV-2 infection becomes an interesting issue on a daily basis. Coffee consumption is connected with reduced COVID-19 risk and […]

Long COVID: Antibodies in cerebrospinal fluid linked with brain fog

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Deep Shukla, 2022 Medical News Today Coronavirus data Brain fog, or cognitive dysfunction, is one of the most common symptoms that health professionals observe in individuals with long COVID, or post-acute COVID-19. A recent study by researchers at the University of California, San Francisco (UCSF) suggests a link between the presence of persistent cognitive symptoms several months after a SARS-CoV-2 […]

Billions Of Copies Of Residual DNA In A Single Dose Of COVID-19 mRNA Vaccine: Preprint

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NOV 2023 – Authored by Marina Zhang via The Epoch Times  A new preprint study up for peer review finds billions of residual DNA fragments in the COVID-19 mRNA vaccine vials. The lead author of the study, molecular virologist David Speicher, who has a doctorate in virology, told The Epoch Times that their study is “the […]

Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs

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Jean-Laurent Casanova1,2,3,4,5 and Mark S. Anderson6,7, Published February 1, 2023 – More infoView PDF Abstract Since 2003, rare inborn errors of human type I IFN immunity have been discovered, each underlying a few severe viral illnesses. Autoantibodies neutralizing type I IFNs due to rare inborn errors of autoimmune regulator (AIRE)–driven T cell tolerance were discovered in 2006, but not […]

Therapeutic potential of convalescent plasma and hyperimmune immunoglobulins against SARS-CoV-2 BQ.1, BQ.1.1, and XBB variants

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Lorenza Bellusci, Hana Golding, and Surender Khurana Journal of Clinical Investigation Published 2023 – More infoView PDF  Convalescent plasma (CP) and hyperimmune intravenous immunoglobulins (IVIGs) are routinely used to treat patients with COVID-19. SARS-CoV-2 Omicron variants continue to evolve, generating multiple sublineages with increased transmissibility and antibody-escape mutations (1, 2). Several Omicron lineages that are currently circulating (BA.4, BA.5, […]

The Unexpected Battle Between Vaccines And The COVID Virus

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NOV 08, 2023 – Authored by Yuhong Dong The Epoch Times  Since the unprecedented COVID-19 global pandemic that started in January 2020, humans have been in a constant battle with the SARS-CoV-2 virus. A series of vaccine versions have been developed and administered globally, beginning in January 2021 when an mRNA vaccine based on the […]

C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps

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Bruna M. Silva,1,2 Giovanni F. Gomes,1 Flavio P. Veras,1 Seppe Cambier,3 Gabriel V.L. Silva,1,2 Andreza U. Quadros,1 Diego B. Caetité,1,2 Daniele C. Nascimento,1,2 Camilla M. Silva,1,2 Juliana C. Silva,1 Samara Damasceno,1 Ayda H. Schneider,1 Fabio Beretta,3 Sabrina S. Batah,4 Icaro M.S. Castro,5 Isadora M. Paiva,1 Tamara Rodrigues,1,2 Ana Salina,1,6 Ronaldo Martins,6,7 Guilherme C.M. Cebinelli,1,2 Naira L. Bibo,1 Daniel M. Jorge,6,7 Helder I. Nakaya,5 Dario S. Zamboni,1,6 Luiz O. Leiria,1,2 Alexandre T. Fabro,4 José C. Alves-Filho,1,2 Eurico Arruda,6,7 Paulo Louzada-Junior,1,8 Renê D. Oliveira,1,8 Larissa D. Cunha,1,6 Pierre […]

Treatments of COVID-19-Associated Taste and Saliva Secretory Disorders

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Hironori Tsuchiya, Christos Rahiotis, Academic Editor and Nikolaos Gkantidis, Academic EditorDent J (Basel). 2023 Jun; 11(6): 140. Published online 2023 May 25. doi: 10.3390/dj11060140, PMCID: PMC10297082 PMID: 37366663 Abstract Since the worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, treating taste and saliva secretory disorders associated with coronavirus disease 2019 (COVID-19) has become a critical issue. The aim of the […]

COVID: The Science™ Concedes the Shots Cause Strokes

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NOV 06, 2023 – Originally published  Armageddon Prose: COVID Shots Cause Strokes, The Science™ Concedes “Older adults who received last year’s COVID booster and a high-dose version of the flu vaccine in a recent study may have a potential increased risk of stroke, according to a new FDA-funded research project. Experts urged that the results […]