SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming
Authors: Chien-Ting Wu , Peter V. Lidsky , Yinghong Xiao , Carlos Milla, Raul Andino, Peter K. Jackson December 01, 2022DOI:https://doi.org/10.1016/j.cell.2022.11.030 Highlights Summary How SARS-CoV-2 penetrates the airway barrier of mucus and periciliary mucins to infect nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we found that the virus attaches to motile cilia via the ACE2 […]