Authors: Cleveland Clinic What is dysautonomia? Dysautonomia is a general term for a group of disorders that share a common problem – that is, an autonomic nervous system (ANS) that doesn’t function as it should. The ANS is the part of the nervous system that controls involuntary body functions (functions you don’t consciously control) like […]
Authors: Medical News Today Cytokine release syndrome (CRS) can cause a variety of symptoms, including fever, headaches, and nausea. The symptoms can become severe quickly. CRS occurs when the immune system responds too aggressively to an infection. It can also happen as a result of some types of immunotherapy. Treatments for CRS typically involve reducing the […]
Authors: Sarah Bradley The news cycle is heavily saturated with stress-inducing information about COVID-19, but one of the most worrying aspects so far has been the huge disparity in the way the novel coronavirus presents itself: Why do some people have no symptoms (or only mild ones), while others are so sick they require ventilation? There isn’t a definitive answer, but many […]
Authors: Sonu Bhaskar,1,2,3,* Akansha Sinha,1,4 Maciej Banach,1,5,6,7 Shikha Mittoo,1,8 Robert Weissert,1,9 Joseph S. Kass,1,10 Santhosh Rajagopal,1,11 Anupama R. Pai,1,12 and Shelby Kutty1,13,14 Cytokine storm is an acute hyperinflammatory response that may be responsible for critical illness in many conditions including viral infections, cancer, sepsis, and multi-organ failure. The phenomenon has been implicated in critically ill patients infected with SARS-CoV-2, the novel coronavirus implicated in […]
Authors: Mehdi Mahmudpour 1, Jamshid Roozbeh 2, Mohsen Keshavarz 1, Shokrollah Farrokhi 3, Iraj Nabipour 4 Patients with COVID-19 who require ICU admission might have the cytokine storm. It is a state of out-of-control release of a variety of inflammatory cytokines. The molecular mechanism of the cytokine storm has not been explored extensively yet. The attachment of SARS-CoV-2 spike glycoprotein with angiotensin-converting enzyme 2 […]
Authors: Yujun Tang,† Jiajia Liu,† Dingyi Zhang, Zhenghao Xu, Jinjun Ji,* and Chengping Wen* Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the pathogen that causes coronavirus disease 2019 (COVID-19). As of 25 May 2020, the outbreak of COVID-19 has caused 347,192 deaths around the world. The current evidence showed that severely ill patients tend to have a high concentration of […]
Authors: Víctor J Costela-Ruiz 1, Rebeca Illescas-Montes 1, Jose M Puerta-Puerta 2, Concepción Ruiz 3, Lucia Melguizo-Rodríguez 1 COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as […]
Authors: Mehmet Soy 1, Gökhan Keser 2, Pamir Atagündüz 3, Fehmi Tabak 4, Işık Atagündüz 5, Servet Kayhan COVID-19 infection has a heterogenous disease course; it may be asymptomatic or causes only mild symptoms in the majority of the cases, while immunologic complications such as macrophage activation syndrome also known as secondary hemophagocytic lymphohistiocytosis, resulting in cytokine storm syndrome and acute respiratory distress syndrome, may […]
Authors: St. Jude Children’s Research Hospital The COVID-19 pandemic continues to cause significant illness and death while treatment options remain limited. St. Jude Children’s Research Hospital scientists have discovered a potential strategy to prevent life-threatening inflammation, lung damage and organ failure in patients with COVID-19. The research appeared online in the journal Cell. The scientists identified […]
Authors: Philip C Robinson, Duncan Richards, Helen L Tanner, Marc Feldmann The COVID-19 pandemic continues to wreak havoc on global health-care systems and to claim an increasing number of lives. Although some treatments have shown promise, including dexamethasone and remdesivir, problems remain with access to medication and high mortality despite treatment. Patient selection also appears […]