Integrative clinical, genomics and metabolomics data analysis for mainstream precision medicine to investigate COVID-19

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Authors: Zeeshan Ahmed, Saman Zeeshan, David J Foran, Lawrence C Kleinman, Fredric E Wondisford,  XinQi Dong Crrespondence to Dr Zeeshan Ahmed, Rutgers Institute for Health, Health Care Policy and Aging Research, Rutgers University, New Brunswick, New Jersey 08901, USA; zahmed@ifh.rutgers.edu Despite significant scientific and medical discoveries, the genetics of novel infectious diseases like COVID-19 remains far from understanding. SARS-CoV-2 […]

8 tools that helped us tackle the coronavirus

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Authors: Ryan Cross , Laura Howes , Megha Satyanarayana ADENOVIRAL VECTORS Viruses might be nature’s most efficient gene-delivery vehicles. At its essence, a virus is simply a package that shuttles genes into a host cell, which it then hijacks to make more viruses. About 4 decades ago, scientists started hijacking the viruses themselves in an attempt to make novel vaccines. The […]

Genomics study identifies routes of transmission of coronavirus in care homes

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Authors: Craig Brierley, University of Cambridge Genomic surveillance—using information about genetic differences between virus samples—can help identify how SARS-CoV-2 spreads in care home settings, whose residents are at particular risk, according to new research published today. Care homes are at high risk of experiencing outbreaks of COVID-19, the disease caused by SARS-CoV-2. Older people and those […]

How genomic epidemiology is tracking the spread of COVID-19 locally and globally

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Auhors: Claire Jarvis, special to C&EN n early April, a paper published in the journal Proceedings of the National Academy of Sciences of the United States of America (PNAS) raised the eyebrows of a number of genomic epidemiologists. It suggested that there were three distinct variants of the novel coronavirus, SARS-CoV-2, spreading in different regions of the […]

A comprehensive map of the SARS-CoV-2 genome

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Authors: Anne Trafton | MIT News Office In early 2020, a few months after the Covid-19 pandemic began, scientists were able to sequence the full genome of SARS-CoV-2, the virus that causes the Covid-19 infection. While many of its genes were already known at that point, the full complement of protein-coding genes was unresolved. Now, after performing […]

Genomics Data Lake

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The Genomics Data Lake provides various public datasets that you can access for free and integrate into your genomics analysis workflows and applications. The datasets include genome sequences, variant info, and subject/sample metadata in BAM, FASTA, VCF, CSV file formats. The Genomics Data Lake is hosted in the West US 2 and West Central US […]

COVID-19 Open Research Dataset

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Full-text and metadata dataset of COVID-19 and coronavirus-related scholarly articles optimized for machine readability and made available for use by the global research community. In response to the COVID-19 pandemic, the Allen Institute for AI has partnered with leading research groups to prepare and distribute the COVID-19 Open Research Dataset (CORD-19). This dataset is a free resource […]

COVID-19 Data Lake

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The COVID-19 Data Lake contains COVID-19 related datasets from various sources. It covers testing and patient outcome tracking data, social distancing policy, hospital capacity, mobility, and so on. The COVID-19 Data Lake is hosted in Azure Data Lake Storage in the East US region. For each dataset, modified versions in csv, json, json-lines, and parquet […]

How genomics will help us track Covid-19

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Authors: MARC DAALDER New Zealand has found itself suddenly plunged into a dire situation: Four new cases of Covid-19 in the community with no obvious link to the border, managed isolation and quarantine facilities or overseas travel. While contact tracing is underway to attempt to find out who infected yesterday’s four cases and search for […]

Bronchiectasis: Mechanisms and Imaging Clues of Associated Common and Uncommon Diseases

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Authors: Bethany Milliron, Travis S Henry, Srihari Veeraraghavan, Brent P Little Bronchiectasis is permanent irreversible dilatation of the airways and occurs in a variety of pathologic processes. Recurrent infection and inflammation and the resulting chemical and cellular cascade lead to permanent architectural changes in the airways. Bronchiectasis can confer substantial potential morbidity, usually secondary to […]