Israeli experts analyze mRNA COVID vaccines long-term effects


Experts believe there will be no long-term side effects to the mRNA vaccines. Authors: By MAAYAN JAFFE-HOFFMAN   AUGUST 30, 2021 22:34 As thousands of Israelis rush back to their health funds in search of a third COVID-19 vaccine shot and a Green Pass from isolation after traveling abroad, others are asking if another injection of messenger RNA […]

Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines


Authors: Bryant, Andrew MSc1,*; Lawrie, Theresa A. MBBCh, PhD2; Dowswell, Therese PhD2; Fordham, Edmund J. PhD2; Mitchell, Scott MBChB, MRCS3; Hill, Sarah R. PhD1; Tham, Tony C. MD, FRCP4 American Journal of Therapeutics: July/August 2021 – Volume 28 – Issue 4 – p e434-e460doi: 10.1097/MJT.0000000000001402 Abstract Background:  Repurposed medicines may have a role against the SARS-CoV-2 virus. The […]

Further evidence supports controversial claim that SARS-CoV-2 genes can integrate with human DNA


Authors: By Jon CohenMay. 6, 2021 , 2:45 PM Science’s COVID-19 reporting is supported by the Heising-Simons Foundation. A team of prominent scientists has doubled down on its controversial hypothesis that genetic bits of the pandemic coronavirus can integrate into our chromosomes and stick around long after the infection is over. If they are right—skeptics have […]

First case of postmortem study in a patient vaccinated against SARS-CoV-2


Author:TorstenHansenaUlfTitzeaNidhi Su AnnKulamadayil-HeidenreichbSabineGlombitzacJohannes, et. al. Highlights • We report on a patient with a single dose of vaccine against SARS-CoV-2. • He developed relevant serum titer levels but died 4 weeks later. • By postmortem molecular mapping, we found viral RNA in nearly all organs examined. • However, we did not observe any characteristic morphological features of COVID-19. • […]

The animal origin of SARS-CoV-2


Authors: Spyros Lytras1, Wei Xia2, Joseph Hughes1, Xiaowei Jiang3, David L. Robertson1  See all authors and affiliationsScience  27 Aug 2021:Vol. 373, Issue 6558, pp. 968-970 DOI: 10.1126/science.abh0117 Although first detected in December 2019, COVID-19 was inferred to be present in Hubei province, China, for about a month before (1). Where did this new human disease come from? To understand the origin […]

Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants


Authors: ViewAmarendra Pegu1,†, Sarah O’Connell1,† View ORCID ProfileStephen D. Schmidt1,†, Sijy O’Dell1,†,  View ORCID ProfileChloe A. Talana1, Lilin Lai2, Jim Albert Science  12 Aug 2021: eabj4176m OI: 10.1126/science.abj4176 Abstract SARS-CoV-2 mutations may diminish vaccine-induced protective immune responses, particularly as antibody titers wane over time. Here, we assess the impact of SARS-CoV-2 variants B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), B.1.429 (Epsilon), […]

Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people


Julia Hippisley-Cox1, Duncan Young2,3, Carol Coupland4, Keith M Channon5, Pui San Tan6, David A Harrison7, Kathryn Rowan8,  Paul Aveyard6, Ian D Pavord9, Peter J Watkinson5,10 Correspondence to Prof Julia Hippisley-Cox, Primary Care Health Sciences, University of Oxford, Oxford OX1  Abstract Background  There is uncertainty about the associations of angiotensive enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) drugs with COVID-19 disease. We studied whether […]

Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches


Authors: Magda Gioia,a,⁎ Chiara Ciaccio,a,⁎ Paolo Calligari,b Giovanna De Simone,c Diego Sbardella,d Grazia Tundo,dGiovanni Francesco Fasciglione,a Alessandra Di Masi,cD onato Di Pierro,a Alessio Bocedi,b Paolo Ascenzi,c,e and Massimo Colettaa,⁎ Biochem Pharmacol. 2020 Dec; 182: 114225.Published online 2020 Sep  doi: 10.1016/j.bcp.2020.114225PMCID: PMC7501082PMID: 32956643 Abstract In the Fall of 2019 a sudden and dramatic outbreak of a pulmonary disease (Coronavirus Disease COVID-19), due […]

‘Natural Immunity Is Really Better’: New Israeli Study Fuels Debate On Vaccination Versus Natural Immunity


Authors: DYLAN HOUSMAN HEALTHCARE REPORTER August 28, 20215:12 PM ET A new study of the power of COVID-19 natural immunity versus the protection provided by vaccines is igniting further debate among scientists on how to assess risk from the virus. The observational study of more than 700,000 Israelis, which hasn’t yet been peer-reviewed, compared three groups: those […]

New COVID variant detected in South Africa, most mutated variant so far


The C.1.2 variant first detected in South Africa is more mutated compared to the original virus than any other known variant. Authors: By TZVI JOFFRE   AUGUST 29, 2021 14:47 A new coronavirus variant, C.1.2, has been detected in South Africa and a number of other countries, with concerns that it could be more infectious and evade vaccines, according […]