Cardiac Troponin-I and COVID-19: A Prognostic Tool for In-Hospital Mortality

Posted on | Posted on John Murphy | Leave a Comment on Cardiac Troponin-I and COVID-19: A Prognostic Tool for In-Hospital Mortality

Authors: Baher Al Abbasi 1, Pedro Torres 1, Fergie Ramos-Tuarez 2, Nakeya Dewaswala 1, Ahmed Abdallah 1, Kai Chen 1, Mohamed Abdul Qader 1, Riya Job 1, Samar Aboulenain 1, Karolina Dziadkowiec 1, Huzefa Bhopalwala 3, Jesus E Pino 2, Robert D Chait 2 Abstract Background: The number of fatalities due to coronavirus disease 2019 (COVID-19) is escalating with more than 800,000 deaths globally. The scientific community remains in urgent need of prognostic tools to determine the probability of survival in […]

More than 1,000 COVID-19 deaths recorded as US returns to April levels

Posted on | Posted on John Murphy | Leave a Comment on More than 1,000 COVID-19 deaths recorded as US returns to April levels

Authors: BY MYCHAEL SCHNELL – 08/18/21 07:27 AM EDT The U.S. recorded more than 1,000 COVID-19 deaths on Tuesday as numbers reach levels last seen in April, largely due to the highly infectious delta variant spreading rapidly throughout the country. The 1,017 coronavirus deaths reported on Tuesday equate to roughly 42 fatalities an hour, according to a Reuters tally of state […]

COVID-19-associated diarrhea

Posted on | Posted on John Murphy | Leave a Comment on COVID-19-associated diarrhea

World J Gastroenterol. 2021 Jun 21; 27(23): 3208–3222.Published online 2021 Jun 21. doi: 10.3748/wjg.v27.i23.3208PMCID: PMC8218355PMID: 34163106 Authors: Klara Megyeri, Áron Dernovics, Zaid I I Al-Luhaibi, and András Rosztóczy Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged as a highly virulent respiratory pathogen that is known as the causative agent of coronavirus disease 2019 (COVID-19). Diarrhea is a common early symptom in […]

GUT SYMPTOMS LINKED WITH COVID-19: A SYSTEMATIC REVIEW

Posted on | Posted on John Murphy | Leave a Comment on GUT SYMPTOMS LINKED WITH COVID-19: A SYSTEMATIC REVIEW

August 2021 Project: Gut microbiota could predict severity of COVID-19 Literature Review of COVID-19 G.I. Complications Authors: Md. Rayhan Mahmud, University of Helsinki, Md Karim Uddin, University of Helsinki, Md. Sajjad Hossain, Jagannath University – Bangladesh, Sharmin Akter, Jagannath University – Bangladesh Gastrointestinal Symptoms Associated With Unfavorable Prognosis of COVID-19 Patients: A Retrospective The roles of […]

ABO blood group and COVID-19: a review on behalf of the ISBT COVID-19 working group

Posted on | Posted on John Murphy | Leave a Comment on ABO blood group and COVID-19: a review on behalf of the ISBT COVID-19 working group

Authors: the ISBT COVID-19 Working Group School of Medicine Abstract Growing evidence suggests that ABO blood group may play a role in the immunopathogenesis of SARS-CoV-2 infection, with group O individuals less likely to test positive and group A conferring a higher susceptibility to infection and propensity to severe disease. The level of evidence supporting […]

Role of neutrophil-epithelial interactions in SARS-CoV-2 infection

Posted on | Posted on John Murphy | Leave a Comment on Role of neutrophil-epithelial interactions in SARS-CoV-2 infection

Authors: By Suchandrima BhowmikAug 15 2021Reviewed by Benedette Cuffari, M.Sc. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the virus that causes coronavirus disease 2019 (COVID-19), is associated with high mortality and hospitalization rates. However, many patients who are infected with SARS-CoV-2 remain asymptomatic or develop mild symptoms. In a recent study published on the […]

Intracellular localization of the SARS coronavirus protein 9b: evidence of active export from the nucleus

Posted on | Posted on John Murphy | Leave a Comment on Intracellular localization of the SARS coronavirus protein 9b: evidence of active export from the nucleus

Authors: Igor Moshynskyy 1, Sathiyanarayanan Viswanathan, Natalia Vasilenko, Vladislav Lobanov, Martin Petric, Lorne A Babiuk, Alexander N Zakhartchouk Abstract Open reading frame 9b (ORF 9b) encodes a 98 amino acid group-specific protein of severe acute respiratory syndrome (SARS) coronavirus (CoV). It has no homology with known proteins and its function in SARS CoV replication has not been determined. The N-terminal part of […]

The Crystal Structure of ORF-9b, a Lipid Binding Protein from the SARS Coronavirus

Posted on | Posted on John Murphy | Leave a Comment on The Crystal Structure of ORF-9b, a Lipid Binding Protein from the SARS Coronavirus

Author links open overlay panelChristophMeier123A. RaduAricescu13ReneAssenberg2Robin T.Aplin2Robert J.C.Gilbert13Jonathan M.Grimes123David I.Stuart123 Summary To achieve the greatest output from their limited genomes, viruses frequently make use of alternative open reading frames, in which translation is initiated from a start codon within an existing gene and, being out of frame, gives rise to a distinct protein product. These alternative protein products are, as yet, […]

UniProtKB – P59636 (ORF9B_SARS)

Posted on | Posted on John Murphy | Leave a Comment on UniProtKB – P59636 (ORF9B_SARS)

Protein: ORF9b protein database Gene: 9b Organism Severe acute respiratory syndrome coronavirus (SARS-CoV) Status Reviewed-Annotation score:-Experimental evidence at protein leveli Functioni Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, […]

SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the AVS/TRAF3/TRAF6 signalosome

Posted on | Posted on John Murphy | Leave a Comment on SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the AVS/TRAF3/TRAF6 signalosome

.J Immunol 2014 Sep 15;193(6):3080-9. doi: 10.4049/jimmunol.1303196. Epub 2014 Aug 18. Chong-Shan Shi 1, Hai-Yan Qi 2, Cedric Boularan 1, Ning-Na Huang 1, Mones Abu-Asab 3, James H Shelhamer 2, John H Kehrl 4 Abstract Coronaviruses (CoV) have recently emerged as potentially serious pathogens that can cause significant human morbidity and death. The severe acute respiratory syndrome (SARS)-CoV was identified as the etiologic agent of the 2002-2003 international SARS outbreak. […]