The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling

Posted on | Posted on John Murphy | Leave a Comment on The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling

Authors: Juan Pablo Robles 1Magdalena Zamora 1Elva Adan-CastroLourdes Siqueiros-MarquezGonzalo Martinez de la EscaleraCarmen Clapp Open AccessDOI:https://doi.org/10.1016/j.jbc.2022.101695 Vascular endothelial cells (ECs) form a critical interface between blood and tissues that maintains whole-body homeostasis. In COVID-19, disruption of the EC barrier results in edema, vascular inflammation, and coagulation, hallmarks of this severe disease. However, the mechanisms by which ECs […]

Resolving “Long-Haul COVID” and Vaccine Toxicity: Neutralizing the Spike Protein

Posted on | Posted on John Murphy | Leave a Comment on Resolving “Long-Haul COVID” and Vaccine Toxicity: Neutralizing the Spike Protein

Authors: Thomas E. Levy, MD, JD Orthomolecular Medicine News Service, June 21, 2021 Although the mainstream media outlets might have you believe otherwise, the vaccines that continue to be administered for the COVID pandemic are emerging as very substantial sources of morbidity and mortality themselves. While the degree to which these negative outcomes of the […]

A New Study Pinpoints a Cause of Long-Haul COVID Symptoms

Posted on | Posted on John Murphy | Leave a Comment on A New Study Pinpoints a Cause of Long-Haul COVID Symptoms

An Attack on Mitochondria? Authors:  MAGGIE RYAN February 2, 2022 As the pandemic continues, long COVID-19 remains very prevalent (affecting between 31 and 69 percent of COVID-19 patients) and somewhat bewildering because there’s no clear connection between the severity of a patient’s initial symptoms and how long they might linger. That was one thing that Irina Petrache, MD, chief of the […]

Do vaccines protect against long COVID? What the data say

Posted on | Posted on John Murphy | Leave a Comment on Do vaccines protect against long COVID? What the data say

Vaccines reduce the risk of developing COVID-19 — but studies disagree on their protective effect against long COVID. Authors: Heidi Ledford Physiotherapist David Putrino’s neurological rehabilitation clinics used to treat about 50 people each week with conditions such as chronic pain, Parkinson’s disease and sports injuries. Then came long COVID. Now, Mount Sinai Hospital’s Abilities […]

New Study Shows Insomnia More Common in COVID-19 Survivors

Posted on | Posted on John Murphy | Leave a Comment on New Study Shows Insomnia More Common in COVID-19 Survivors

Authors: Sarah Shoen Updated October 27, 2021 Home / Sleep News / New Study Shows Insomnia More Common in COVID-19 Survivors COVID-19 infection may have a large neurological and psychiatric impact on as many as one-third of its survivors. A study published by Lancet Psychiatry finds that insomnia may be one of the most common neurological and psychiatric outcomes from COVID-19. […]

6-month neurological and psychiatric outcomes in 236,379 survivors of COVID-19: a retrospective cohort study using electronic health records

Posted on | Posted on John Murphy | Leave a Comment on 6-month neurological and psychiatric outcomes in 236,379 survivors of COVID-19: a retrospective cohort study using electronic health records

Authors: Maxime Taquet, John R Geddes, Masud Husain, Sierra Luciano, Paul J Harrison Summary Background Neurological and psychiatric sequelae of COVID-19 have been reported, but more data are needed to adequately assess the effects of COVID-19 on brain health. We aimed to provide robust estimates of incidence rates and relative risks of neurological and psychiatric […]

What do we know about covid vaccines and preventing transmission?

Posted on | Posted on John Murphy | Leave a Comment on What do we know about covid vaccines and preventing transmission?

BMJ 2022; 376 doi: https://doi.org/10.1136/bmj.o298  (Published 04 February 2022) Cite as:  BMJ 2022;376:o298 Authors: Chris Stokel-Walker, Vaccines that work against SARS-CoV-2 have helped change the course of the pandemic by reducing illness and hospital admissions. But Chris Stokel-Walker asks what we know about their impact on preventing transmission. The range of vaccines developed in record time by pharmaceutical companies and research laboratories […]

Sleep disorders and COVID-19

Posted on | Posted on John Murphy | Leave a Comment on Sleep disorders and COVID-19

Authors: Sushanth Bhata,∗ and Sudhansu Chokrovertyb Sleep Med. 2021 Jul 18doi: 10.1016/j.sleep.2021.07.021 Abstract This chapter summarizes the known associations between COVID-19 and sleep dysfunction, including insomnia, excessive daytime sleepiness, restless legs syndrome and nightmares, and touches upon pandemic-related considerations for obstructive sleep apnea and continuous positive airway pressure treatment. Treatment strategies and management approaches are also briefly discussed.Keywords: Coronasomnia, COVIDsomnia, […]

COVID‐19‐induced endotheliitis: emerging evidence and possible therapeutic strategies

Posted on | Posted on John Murphy | Leave a Comment on COVID‐19‐induced endotheliitis: emerging evidence and possible therapeutic strategies

Authors: Eleonora Calabretta, 1 , 12 Jose M. Moraleda, 2 Massimo Iacobelli, 3 Ruben Jara, 4 Israel Vlodavsky, 5 Peter O’Gorman, 6 Antonio Pagliuca, 7 Clifton Mo, 8 Rebecca M. Baron, 9 Alessio Aghemo, 10 , 12 Robert Soiffer, 8 Jawed Fareed, 11 Carmelo Carlo‐Stella, 1 , 12 , * and Paul Richardson 8 , * Br J Haematol. 2021 Apr; 193(1): 43–51.Published online 2021 Feb 4.  doi:  10.1111/bjh.17240 PMCID:  PMC8014053PMID: 33538335 Introduction The coronavirus disease 2019 (COVID‐19) pandemic, a viral illness caused by the severe acute respiratory syndrome coronavirus‐2 […]

Ophthalmic Manifestations Of Coronavirus (COVID-19)

Posted on | Posted on John Murphy | Leave a Comment on Ophthalmic Manifestations Of Coronavirus (COVID-19)

Authors: Katherine Hu; Jay Patel; Cole Swiston; Bhupendra C. Patel. January 8, 2022. Introduction Since December 2019, coronavirus disease 2019 (COVID-19) has become a global pandemic caused by the highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).[1] Initially, there were several reports of eye redness and irritation in COVID-19 patients, both anecdotal and published, supporting conjunctivitis as an ocular manifestation […]