The coagulopathy, endotheliopathy, and vasculitis of COVID-19

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Authors: Toshiaki Iba 1, Jean Marie Connors 2, Jerrold H Levy 3 PMID: 32918567 PMCID: PMC7486586 DOI: 10.1007/s00011-020-01401-6 Abstract Background COVID-19-associated coagulopathy (CAC) characterized by the elevated D-dimer without remarkable changes of other global coagulation markers is associated with various thrombotic complications and disease severity. The purpose of this review is to elucidate the pathophysiology of this unique coagulopathy. Methods The authors performed […]

COVID-19-associated coagulopathy: An exploration of mechanisms

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Authors: Meaghan E Colling 1, Yogendra Kanthi 2 PMID: 32558620 PMCID: PMC7306998 OI: 10.1177/1358863X20932640 Abstract An ongoing global pandemic of viral pneumonia (coronavirus disease [COVID-19]), due to the virus SARS-CoV-2, has infected millions of people and remains a threat to many more. Most critically ill patients have respiratory failure and there is an international effort to understand mechanisms and predictors of […]

Role of von Willebrand Factor in COVID-19 Associated Coagulopathy

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Authors: Zhen W Mei, Xander M R van Wijk, Huy P Pham, Maximo J Marin The Journal of Applied Laboratory Medicine, Volume 6, Issue 5, September 2021, Pages 1305–1315,  https://doi.org/10.1093/jalm/jfab042Published: 13 June 2021 Abstract Background COVID-19, the disease caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) can present with symptoms ranging from none to severe. Thrombotic events occur […]

Elevated P-Selectin in Severe Covid-19: Considerations for Therapeutic Options

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Authors: Chiara Agrati,1Veronica Bordoni,1Alessandra Sacchi,1Nicola Petrosillo,1Emanuele Nicastri,1Franca Del Nonno,1Gianpiero D’Offizi,1Fabrizio Palmieri,1Luisa Marchioni,1Maria Rosaria Capobianchi,1Andrea Antinori,1Giuseppe Ippolito,1 and Michele Bibas1 Mediterr J Hematol Infect Dis. 2021; 13(1): e2021016.Published online 2021 Mar 1.  doi:  10.4084/MJHID.2021.016 Abstract Background Coronavirus disease 2019 (COVID-19) is mainly a respiratory tract disease and acute respiratory failure with diffuse microvascular pulmonary thrombosis are critical aspects of […]

Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome

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Authors: Carlo Cervia, Yves Zurbuchen, Patrick Taeschler, Tala Ballouz, Dominik Menges, Sara Hasler,  Sarah Adamo, Miro E. Raeber, Esther Bächli, Alain Rudiger, Melina Stüssi-Helbling, Lars C. Huber,  Jakob Nilsson, Ulrike Held, Milo A. Puhan & Onur Boyman  Nature Communications volume 13, Article number: 446 (2022)  Abstract Following acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a significant proportion of individuals develop prolonged symptoms, a serious condition termed post-acute coronavirus disease 2019 (COVID-19) […]

Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae

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Authors: Yapeng Su 28, Dan Yuan 28, Daniel G. Chen 28,Mark M. Davis, Jason D. Goldman, James R. Heath 29 Highlights Longitudinal multiomics associate PASC with autoantibodies, viremia and comorbidities Reactivation of latent viruses during initial infection may contribute to PASC Subclinical autoantibodies negatively correlate with anti-SARS-CoV-2 antibodies Gastrointestinal PASC uniquely present with post-acute expansion of cytotoxic T cells […]

Why are we vaccinating children against COVID-19?

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Authors: Ronald N.Kostoffa DanielaCalinab DarjaKanducc Michael B.Briggsd Panayiotis Vlachoyiannopoulose Andrey A.Svistunovf AristidisTsatsakisg Highlights • Bulk of COVID-19 per capita deaths occur in elderly with high comorbidities. •Per capita COVID-19 deaths are negligible in children. •Clinical trials for these inoculations were very short-term. •Clinical trials did not address long-term effects most relevant to children. •High post-inoculation deaths reported […]

Speech Therapist: 364% Surge In Baby And Toddler Referrals Thanks To Mask Wearing

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A speech therapist says that mask wearing during the pandemic has caused a 364% increase in patient referrals of babies and toddlers. Authors: by Paul Joseph Watson via Summit News, SUNDAY, JAN 30, 2022 – 03:50 PM Jaclyn Theek told WPBF News that before the pandemic, only 5 per cent of patients were babies and […]

Close relatives of MERS-CoV in bats use ACE2 as their functional receptors

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Authors: Qing Xiong,  View ORCID , , ei Cao,  Chengbao Ma,  Chen Liu, Junyu Si,  Peng Liu,  Mengxue Gu,  Chunli Wang, Lulu Shi, Fei Tong, Meiling Huang, Jing Li, Chufeng Zhao,  Chao Shen,   Yu Chen,   Huabin Zhao,  Ke Lan,  Xiangxi Wang,  Huan Yan Summary Middle East Respiratory Syndrome coronavirus (MERS-CoV) and several bat coronaviruses employ Dipeptidyl peptidase-4 (DPP4) as their functional receptors1–4. However, the receptor for NeoCoV, the closest MERS-CoV relative yet discovered in bats, remains enigmatic5. In this study, we unexpectedly found that […]