The COVID-19 Long Haul Foundation – Page 145 – Treatment, Referral & Educational Support for Illnesses & Vaccine Injury

GUT SYMPTOMS LINKED WITH COVID-19: A SYSTEMATIC REVIEW

August 17, 2021 | John Murphy | Leave a Comment

August 2021 Project: Gut microbiota could predict severity of COVID-19 Literature Review of COVID-19 G.I. Complications Authors: Md. Rayhan Mahmud, University of Helsinki, Md Karim Uddin, University of Helsinki, Md. Sajjad Hossain, Jagannath University – Bangladesh, Sharmin Akter, Jagannath University – Bangladesh Gastrointestinal Symptoms Associated With Unfavorable Prognosis of COVID-19 Patients: A Retrospective The roles of […]

ABO blood group and COVID-19: a review on behalf of the ISBT COVID-19 working group

August 17, 2021 | John Murphy | Leave a Comment

Authors: the ISBT COVID-19 Working Group School of Medicine Abstract Growing evidence suggests that ABO blood group may play a role in the immunopathogenesis of SARS-CoV-2 infection, with group O individuals less likely to test positive and group A conferring a higher susceptibility to infection and propensity to severe disease. The level of evidence supporting […]

Role of neutrophil-epithelial interactions in SARS-CoV-2 infection

August 17, 2021 | John Murphy | Leave a Comment

Authors: By Suchandrima BhowmikAug 15 2021Reviewed by Benedette Cuffari, M.Sc. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the virus that causes coronavirus disease 2019 (COVID-19), is associated with high mortality and hospitalization rates. However, many patients who are infected with SARS-CoV-2 remain asymptomatic or develop mild symptoms. In a recent study published on the […]

Intracellular localization of the SARS coronavirus protein 9b: evidence of active export from the nucleus

August 17, 2021 | John Murphy | Leave a Comment

Authors: Igor Moshynskyy 1, Sathiyanarayanan Viswanathan, Natalia Vasilenko, Vladislav Lobanov, Martin Petric, Lorne A Babiuk, Alexander N Zakhartchouk Abstract Open reading frame 9b (ORF 9b) encodes a 98 amino acid group-specific protein of severe acute respiratory syndrome (SARS) coronavirus (CoV). It has no homology with known proteins and its function in SARS CoV replication has not been determined. The N-terminal part of […]

The Crystal Structure of ORF-9b, a Lipid Binding Protein from the SARS Coronavirus

August 17, 2021 | John Murphy | Leave a Comment

Author links open overlay panelChristophMeier123A. RaduAricescu13ReneAssenberg2Robin T.Aplin2Robert J.C.Gilbert13Jonathan M.Grimes123David I.Stuart123 Summary To achieve the greatest output from their limited genomes, viruses frequently make use of alternative open reading frames, in which translation is initiated from a start codon within an existing gene and, being out of frame, gives rise to a distinct protein product. These alternative protein products are, as yet, […]

UniProtKB – P59636 (ORF9B_SARS)

August 17, 2021 | John Murphy | Leave a Comment

Protein: ORF9b protein database Gene: 9b Organism Severe acute respiratory syndrome coronavirus (SARS-CoV) Status Reviewed-Annotation score:-Experimental evidence at protein leveli Functioni Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, […]

SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the AVS/TRAF3/TRAF6 signalosome

August 17, 2021 | John Murphy | Leave a Comment

.J Immunol 2014 Sep 15;193(6):3080-9. doi: 10.4049/jimmunol.1303196. Epub 2014 Aug 18. Chong-Shan Shi 1, Hai-Yan Qi 2, Cedric Boularan 1, Ning-Na Huang 1, Mones Abu-Asab 3, James H Shelhamer 2, John H Kehrl 4 Abstract Coronaviruses (CoV) have recently emerged as potentially serious pathogens that can cause significant human morbidity and death. The severe acute respiratory syndrome (SARS)-CoV was identified as the etiologic agent of the 2002-2003 international SARS outbreak. […]

‘We are on fire’: Five U.S. states set new records for Covid cases as hospitalizations rise

August 17, 2021 | John Murphy | Leave a Comment

PUBLISHED MON, AUG 16 20213:54 PM EDTUPDATED MON, AUG 16 20214:49 PM EDT KEY POINTS Nationwide, less than 11% of all hospital beds are being used by Covid patients. In Oregon, it’s 11.4%, Hawaii is at 12.1%, followed by Louisiana at 20.4%, Mississippi at 18.7% and Florida at 28.2%. The states with higher vaccination rates […]

Inflammasome activation at the crux of severe COVID-19

August 16, 2021 | John Murphy | Leave a Comment

Authors: Setu M. Vora,1,2Judy Lieberman,2,3 and Hao Wu1,2 Abstract The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly people and those with co-morbidities such as obesity and diabetes. Severe disease is characterized by dysregulated cytokine release, pneumonia and acute lung injury, which can […]

No point vaccinating those who’ve had COVID-19: Cleveland Clinic study suggests

August 16, 2021 | John Murphy | Leave a Comment

Authors: By Dr. Sanchari Sinha Dutta, Ph.D.Jun 8 2021 Scientists from the Cleveland Clinic, USA, have recently evaluated the effectiveness of coronavirus disease 2019 COVID-19) vaccination among individuals with or without a history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study findings reveal that individuals with previous SARS-CoV-2 infection do not get additional […]