SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

Posted on | Posted on John Murphy | Leave a Comment on SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

Authors: Yuyang Lei,1,2,*Jiao Zhang,1,2,5,*Cara R. Schiavon,8,9Ming He,5Lili Chen,2Hui Shen,5,10Yichi Zhang,5Qian Yin,2Yoshitake Cho,5Leonardo Andrade,8Gerald S. Shadel,9Mark Hepokoski,6Ting Lei,3Hongliang Wang,4Jin Zhang,7Jason X.-J. Yuan,6Atul Malhotra,6Uri Manor,8,†Shengpeng Wang,2,†Zu-Yi Yuan,1,† and John Y-J. Shyy5,† SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection relies on the binding of S protein (Spike glycoprotein) to ACE (angiotensin-converting enzyme) 2 in the host cells. Vascular endothelium […]

THE NOVEL CORONAVIRUS’ SPIKE PROTEIN PLAYS ADDITIONAL KEY ROLE IN ILLNESS

Posted on | Posted on John Murphy | Leave a Comment on THE NOVEL CORONAVIRUS’ SPIKE PROTEIN PLAYS ADDITIONAL KEY ROLE IN ILLNESS

Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that the virus spike proteins (which behave very […]

VAERS Summary for COVID-19 Vaccines through 11/05/2021

Posted on | Posted on John Murphy | Leave a Comment on VAERS Summary for COVID-19 Vaccines through 11/05/2021

Official Reported Vaccine Adverse Events in the FDA Data Base For a Complete Report of All Vaccine Reported Adverse Events Through November 5th, 2021 Click Link Below: http://vaersanalysis.info/wp-content/uploads/2021/11/VAERS-Summary-11052021-3.pdf

Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalizations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data

Posted on | Posted on John Murphy | Leave a Comment on Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalizations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data

Eric J HaasFrederick J AnguloJohn M McLaughlinEmilia AnisShepherd R SingerFarid KhanNati BrooksMeir SmajaGabriel MircusKaijie PanJo SouthernDavid L SwerdlowLuis JodarYeheskel LevySharon Alroy-PreisAuthors: During the analysis period (Jan 24 to April 3, 2021), there were 232 268 SARS-CoV-2 infections, 7694 COVID-19 hospitalizations, 4481 severe or critical COVID-19 hospitalizations, and 1113 COVID-19 deaths in people aged 16 years […]

Effectiveness of mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: a retrospective cohort study

Posted on | Posted on John Murphy | Leave a Comment on Effectiveness of mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: a retrospective cohort study

Authors: Sara YTartofPhDaeJeff MSlezakMSaHeidiFischerPhDaVennisHongMPHaBradley KAckersonMDbOmesh NRanasingheMPHaTimothy BFranklandMAcOluwaseye AOgunMDaJoann MZamparoMPHdSharonGrayMSdSrinivas RValluriPhDdKaijePanMSdFrederick JAnguloPhDdLuisJodarPhDdJohn MMcLaughlinPhDd Between Dec 14, 2020, and Aug 8, 2021, of 4 920 549 individuals assessed for eligibility, we included 3 436 957 (median age 45 years [IQR 29–61]; 1 799 395 [52·4%] female and 1 637 394 [47·6%] male). For fully vaccinated individuals, effectiveness against SARS-CoV-2 infections was 73% (95% CI 72–74) […]

New England Journal of Medicine

Posted on | Posted on John Murphy | Leave a Comment on New England Journal of Medicine

Published Articles COOVID 2021 A collection of articles and other resources on the Coronavirus (Covid-19) outbreak, including clinical reports, management guidelines, and commentary. https://www.nejm.org/coronavirus?query=main_nav_lg Covid-19 Vaccine Resource Center A collection of resources on Covid-19 vaccines, including published research, continuing medical education, and commentary.  https://www.nejm.org/covid-vaccine

Something Really Strange Is Happening At Hospitals All Over America

Posted on | Posted on John Murphy | Leave a Comment on Something Really Strange Is Happening At Hospitals All Over America

Authors: Authored by Michael Snyder via TheMostImportantNews.com, TURSDAY, NOV 04, 2021 – 05:11 In a year that has been filled with so many mysteries already, I have another very odd one to share with you.  Emergency rooms are filled to overflowing all over America, and nobody can seem to explain why this is happening.  Right now, the […]

Latest Lancet Study Exposes Limits Of Vaccines At Preventing COVID Infection

Posted on | Posted on John Murphy | Leave a Comment on Latest Lancet Study Exposes Limits Of Vaccines At Preventing COVID Infection

FRIDAY, OCT 29, 2021 – 05:45 PM The Lancet has just released another study comparing the efficacy of COVID vaccines to the efficacy of protection provided by previous COVID infections. Their conclusion: while vaccines lower the risk of infections with the delta variant within households, those who are fully vaccinated are still vulnerable to a […]

Inside the life of a COVID long-hauler who “fought like an animal” to make it out of the hospital after 299 days

Posted on | Posted on John Murphy | Leave a Comment on Inside the life of a COVID long-hauler who “fought like an animal” to make it out of the hospital after 299 days

OCTOBER 27, 2021 / 10:44 AM / CBS NEWS The past year has seen some dramatic swings in America’s fight against COVID-19. But while the number of COVID cases are trending downward, some long-haulers are having a hard time recovering from the disease.  Alex Castro of Sandy, Oregon, used to be able to swim, cook and hike, but now […]

Vaccinated just as likely to spread delta variant within household as unvaccinated: study

Posted on | Posted on John Murphy | Leave a Comment on Vaccinated just as likely to spread delta variant within household as unvaccinated: study

Authors: BY CAROLINE VAKIL – 10/29/21 09:07 AM EDT People who have received COVID-19 vaccinations are able to spread the delta variant within their household despite their vaccination status just as easily as unvaccinated individuals, a new study published on Friday shows. According to the study published in The Lancet Infectious Diseases journal, people who contracted COVID-19 had a similar viral load regardless […]